Nephrolithiasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Formation of stones in the KIDNEY. (Experimental Factor Ontology, EFO_0004253)
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Genes

623 genes co-occuring with the disease Nephrolithiasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PTH parathyroid hormone 3.511
CLCN5 chloride channel, voltage-sensitive 5 3.337
AGXT alanine-glyoxylate aminotransferase 3.229
CASR calcium-sensing receptor 3.116
GRHPR glyoxylate reductase/hydroxypyruvate reductase 3.002
CLDN14 claudin 14 2.966
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.961
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.925
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.903
UMOD uromodulin 2.88
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.88
SPP1 secreted phosphoprotein 1 2.862
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.858
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.839
CLDN16 claudin 16 2.828
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.822
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.807
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.793
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.792
OCRL oculocerebrorenal syndrome of Lowe 2.782
ALB albumin 2.762
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.74
FGF23 fibroblast growth factor 23 2.708
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.653
XDH xanthine dehydrogenase 2.623
CLDN19 claudin 19 2.617
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.566
MEN1 multiple endocrine neoplasia I 2.534
REN renin 2.494
INS insulin 2.46
APRT adenine phosphoribosyltransferase 2.413
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.398
AMBP alpha-1-microglobulin/bikunin precursor 2.394
HAVCR1 hepatitis A virus cellular receptor 1 2.385
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.381
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.375
CDC73 cell division cycle 73 2.352
MGP matrix Gla protein 2.344
ACE angiotensin I converting enzyme 2.333
CRP C-reactive protein, pentraxin-related 2.308
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.283
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.254
LRP2 low density lipoprotein receptor-related protein 2 2.236
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.225
CST3 cystatin C 2.223
CLCNKB chloride channel, voltage-sensitive Kb 2.22
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.206
PHC3 polyhomeotic homolog 3 (Drosophila) 2.198
KL klotho 2.198
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.194
IL6 interleukin 6 2.193
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.181
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.18
IL1B interleukin 1, beta 2.168
BGLAP bone gamma-carboxyglutamate (gla) protein 2.159
LCN2 lipocalin 2 2.133
PHEX phosphate regulating endopeptidase homolog, X-linked 2.132
EMP1 epithelial membrane protein 1 2.131
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.121
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.12
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.117
TNF tumor necrosis factor 2.115
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.11
PTHLH parathyroid hormone-like hormone 2.104
AQP2 aquaporin 2 (collecting duct) 2.103
GC group-specific component (vitamin D binding protein) 2.093
CHRM3 cholinergic receptor, muscarinic 3 2.088
B2M beta-2-microglobulin 2.061
DNAH8 dynein, axonemal, heavy chain 8 2.059
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.058
ALPL alkaline phosphatase, liver/bone/kidney 2.056
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.054
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.053
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.046
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.042
CLCN4 chloride channel, voltage-sensitive 4 2.035
AHSG alpha-2-HS-glycoprotein 2.026
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.019
CCL2 chemokine (C-C motif) ligand 2 2.008
PKD1 polycystic kidney disease 1 (autosomal dominant) 1.997
AVP arginine vasopressin 1.981
WDR72 WD repeat domain 72 1.966
POMC proopiomelanocortin 1.965
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.962
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.942
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.936
TGFB1 transforming growth factor, beta 1 1.932
GCM2 glial cells missing homolog 2 (Drosophila) 1.924
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 1.921
MOCOS molybdenum cofactor sulfurase 1.916
SLC26A7 solute carrier family 26 (anion exchanger), member 7 1.911
DGKH diacylglycerol kinase, eta 1.911
OGA O-GlcNAcase 1.909
GCG glucagon 1.895
CLCN7 chloride channel, voltage-sensitive 7 1.895
AVPR2 arginine vasopressin receptor 2 1.894
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 1.894
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.892
F2 coagulation factor II (thrombin) 1.881
PTH1R parathyroid hormone 1 receptor 1.881
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.881
IGF1 insulin-like growth factor 1 (somatomedin C) 1.863
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.862
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.862
NLRP3 NLR family, pyrin domain containing 3 1.859
GPX3 glutathione peroxidase 3 1.855
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 1.855
CA2 carbonic anhydrase II 1.849
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.848
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.839
RGS14 regulator of G-protein signaling 14 1.837
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.824
GAST gastrin 1.821
GPX6 glutathione peroxidase 6 1.816
GPX7 glutathione peroxidase 7 1.814
GPX5 glutathione peroxidase 5 1.812
GPX2 glutathione peroxidase 2 1.811
IL18 interleukin 18 1.81
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.81
GPX8 glutathione peroxidase 8 (putative) 1.809
PRL prolactin 1.801
GANAB glucosidase, alpha; neutral AB 1.8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.8
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.799
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.796
PDZK1 PDZ domain containing 1 1.792
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 1.789
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.784
SLC26A8 solute carrier family 26 (anion exchanger), member 8 1.778
OAT ornithine aminotransferase 1.777
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 1.771
LEP leptin 1.771
CLDN2 claudin 2 1.766
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.764
CLCN3 chloride channel, voltage-sensitive 3 1.756
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 1.753
FN1 fibronectin 1 1.749
FOXI1 forkhead box I1 1.741
CLCNKA chloride channel, voltage-sensitive Ka 1.731
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.725
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.718
HMOX1 heme oxygenase 1 1.716
IL10 interleukin 10 1.709
ADCY10 adenylate cyclase 10 (soluble) 1.705
SLC26A9 solute carrier family 26 (anion exchanger), member 9 1.698
CD4 CD4 molecule 1.696
EPO erythropoietin 1.694
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.69
HGD homogentisate 1,2-dioxygenase 1.687
IL1A interleukin 1, alpha 1.685
CD44 CD44 molecule (Indian blood group) 1.68
APOL1 apolipoprotein L, 1 1.679
WNK4 WNK lysine deficient protein kinase 4 1.673
ADIPOQ adiponectin, C1Q and collagen domain containing 1.672
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.672
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.666
SST somatostatin 1.661
SOST sclerostin 1.657
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 1.65
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.647
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.643
PXDNL peroxidasin-like 1.628
PXDN peroxidasin 1.624
CALB1 calbindin 1, 28kDa 1.623
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.622
PRODH2 proline dehydrogenase (oxidase) 2 1.619
TLR4 toll-like receptor 4 1.619
IFNG interferon, gamma 1.615
NOX4 NADPH oxidase 4 1.615
OSGEP O-sialoglycoprotein endopeptidase 1.613
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.612
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.608
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.605
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.599
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.595
PPARG peroxisome proliferator-activated receptor gamma 1.594
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.592
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.59
RUNX2 runt-related transcription factor 2 1.589
CKMT1B creatine kinase, mitochondrial 1B 1.589
CKM creatine kinase, muscle 1.589
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.588
DMP1 dentin matrix acidic phosphoprotein 1 1.587
CKB creatine kinase, brain 1.586
MINDY4 MINDY lysine 48 deubiquitinase 4 1.584
SLC16A9 solute carrier family 16, member 9 1.581
ACTB actin, beta 1.571
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.569
MPO myeloperoxidase 1.563
CCDC144A coiled-coil domain containing 144A 1.557
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 1.554
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.553
BCL2 B-cell CLL/lymphoma 2 1.552
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 1.551
RET ret proto-oncogene 1.551
COL4A5 collagen, type IV, alpha 5 1.543
OSTM1 osteopetrosis associated transmembrane protein 1 1.536
F3 coagulation factor III (thromboplastin, tissue factor) 1.529
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 1.526
CXCL8 chemokine (C-X-C motif) ligand 8 1.52
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.52
CLCN6 chloride channel, voltage-sensitive 6 1.517
HLA-B major histocompatibility complex, class I, B 1.517
PREPL prolyl endopeptidase-like 1.514
CLCN1 chloride channel, voltage-sensitive 1 1.511
MTNR1A melatonin receptor 1A 1.508
TP53 tumor protein p53 1.506
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.5
GLP1R glucagon-like peptide 1 receptor 1.5
IL17A interleukin 17A 1.491
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.491
AQP1 aquaporin 1 (Colton blood group) 1.485
ORAI1 ORAI calcium release-activated calcium modulator 1 1.484
SLC26A5 solute carrier family 26 (anion exchanger), member 5 1.478
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.477
HIBADH 3-hydroxyisobutyrate dehydrogenase 1.476
FAM20A family with sequence similarity 20, member A 1.473
PNLIP pancreatic lipase 1.473
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.473
CLDN10 claudin 10 1.472
NOS3 nitric oxide synthase 3 (endothelial cell) 1.47
FAM20C family with sequence similarity 20, member C 1.469
GHRL ghrelin/obestatin prepropeptide 1.466
ESR1 estrogen receptor 1 1.464
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.462
HNF1B HNF1 homeobox B 1.46
MEPE matrix extracellular phosphoglycoprotein 1.459
WNK1 WNK lysine deficient protein kinase 1 1.458
CHGA chromogranin A 1.456
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.456
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.452
MB myoglobin 1.451
CCK cholecystokinin 1.45
CYBB cytochrome b-245, beta polypeptide 1.445
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.444
FABP1 fatty acid binding protein 1, liver 1.444
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 1.444
CTNS cystinosin, lysosomal cystine transporter 1.444
SLC17A4 solute carrier family 17, member 4 1.443
GSR glutathione reductase 1.442
PDILT protein disulfide isomerase-like, testis expressed 1.435
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.433
KRT7 keratin 7, type II 1.432
EGF epidermal growth factor 1.43
ICAM1 intercellular adhesion molecule 1 1.429
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.429
BMP2 bone morphogenetic protein 2 1.428
CA14 carbonic anhydrase XIV 1.427
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.427
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.426
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.426
MGAM maltase-glucoamylase 1.424
CYCS cytochrome c, somatic 1.423
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.422
SI sucrase-isomaltase (alpha-glucosidase) 1.422
IL2 interleukin 2 1.421
ZNF365 zinc finger protein 365 1.42
STATH statherin 1.419
SIRT1 sirtuin 1 1.418
MMP9 matrix metallopeptidase 9 1.416
S100G S100 calcium binding protein G 1.415
DPP4 dipeptidyl-peptidase 4 1.415
BAX BCL2-associated X protein 1.412
AMN amnion associated transmembrane protein 1.412
TG thyroglobulin 1.408
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.408
FXYD2 FXYD domain containing ion transport regulator 2 1.4
MUC1 mucin 1, cell surface associated 1.397
COL4A4 collagen, type IV, alpha 4 1.396
APOM apolipoprotein M 1.395
PPARA peroxisome proliferator-activated receptor alpha 1.389
CLU clusterin 1.387
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 1.386
SP7 Sp7 transcription factor 1.386
CD8A CD8a molecule 1.384
CP ceruloplasmin (ferroxidase) 1.379
SIRT3 sirtuin 3 1.378
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 1.373
IBSP integrin-binding sialoprotein 1.37
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.369
TJP1 tight junction protein 1 1.368
NFE2L2 nuclear factor, erythroid 2-like 2 1.368
IL4 interleukin 4 1.367
GDNF glial cell derived neurotrophic factor 1.362
CA13 carbonic anhydrase XIII 1.359
CA3 carbonic anhydrase III 1.358
CA12 carbonic anhydrase XII 1.356
SYP synaptophysin 1.355
COQ6 coenzyme Q6 monooxygenase 1.355
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.354
LTF lactotransferrin 1.35
LDHA lactate dehydrogenase A 1.35
CALCR calcitonin receptor 1.35
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.349
KLK3 kallikrein-related peptidase 3 1.348
NALCN sodium leak channel, non selective 1.348
CA8 carbonic anhydrase VIII 1.347
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 1.344
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.343
CALML5 calmodulin-like 5 1.343
RHCG Rh family, C glycoprotein 1.342
GATA3 GATA binding protein 3 1.342
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.339
CALML4 calmodulin-like 4 1.339
CALML6 calmodulin-like 6 1.339
KRT20 keratin 20, type I 1.338
COL1A2 collagen, type I, alpha 2 1.338
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.338
G6PD glucose-6-phosphate dehydrogenase 1.337
SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.337
CALML3 calmodulin-like 3 1.336
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.336
SMAD3 SMAD family member 3 1.335
CARMIL1 capping protein regulator and myosin 1 linker 1 1.331
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.331
CA5B carbonic anhydrase VB, mitochondrial 1.329
EVI5L ecotropic viral integration site 5-like 1.329
APOB apolipoprotein B 1.327
ANXA2 annexin A2 1.326
ITPKC inositol-trisphosphate 3-kinase C 1.321
CA5A carbonic anhydrase VA, mitochondrial 1.32
JUN jun proto-oncogene 1.319
ANXA5 annexin A5 1.315
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.314
STK39 serine threonine kinase 39 1.314
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.313
CA6 carbonic anhydrase VI 1.313
MME membrane metallo-endopeptidase 1.309
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.309
FGF7 fibroblast growth factor 7 1.306
ANXA1 annexin A1 1.306
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.306
LGALS3 lectin, galactoside-binding, soluble, 3 1.305
AMY2A amylase, alpha 2A (pancreatic) 1.305
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.305
C3 complement component 3 1.304
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.303
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.303
SHBG sex hormone-binding globulin 1.3
PAX8 paired box 8 1.3
ACE2 angiotensin I converting enzyme 2 1.299
PPY pancreatic polypeptide 1.298
PTH2R parathyroid hormone 2 receptor 1.295
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.295
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.295
PAX2 paired box 2 1.295
AIRE autoimmune regulator 1.294
DZIP1L DAZ interacting zinc finger protein 1-like 1.29
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.288
DGKD diacylglycerol kinase, delta 130kDa 1.281
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.28
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.279
KEAP1 kelch-like ECH-associated protein 1 1.276
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.276
CA7 carbonic anhydrase VII 1.275
RETNLB resistin like beta 1.275
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.275
KNG1 kininogen 1 1.274
APOA1 apolipoprotein A-I 1.274
KLHL3 kelch-like family member 3 1.273
CD68 CD68 molecule 1.273
EDN1 endothelin 1 1.273
RETN resistin 1.272
PON1 paraoxonase 1 1.272
INMT indolethylamine N-methyltransferase 1.272
NCF1 neutrophil cytosolic factor 1 1.272
HP haptoglobin 1.271
PRKD1 protein kinase D1 1.27
CA1 carbonic anhydrase I 1.269
VCAM1 vascular cell adhesion molecule 1 1.268
PNP purine nucleoside phosphorylase 1.265
FGF5 fibroblast growth factor 5 1.262
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.262
SCNN1B sodium channel, non voltage gated 1 beta subunit 1.262
HPN hepsin 1.261
COQ8B coenzyme Q8B 1.259
CYBA cytochrome b-245, alpha polypeptide 1.256
AMY1B amylase, alpha 1B (salivary) 1.256
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.253
RHBG Rh family, B glycoprotein (gene/pseudogene) 1.253
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 1.252
CSF1 colony stimulating factor 1 (macrophage) 1.252
PRTN3 proteinase 3 1.251
ACP5 acid phosphatase 5, tartrate resistant 1.251
AMY2B amylase, alpha 2B (pancreatic) 1.251
WT1 Wilms tumor 1 1.251
SMAD9 SMAD family member 9 1.25
TFF1 trefoil factor 1 1.249
CAMP cathelicidin antimicrobial peptide 1.249
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.246
FGF8 fibroblast growth factor 8 (androgen-induced) 1.244
RIMBP3 RIMS binding protein 3 1.241
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.241
GNAS GNAS complex locus 1.238
NQO1 NAD(P)H dehydrogenase, quinone 1 1.238
MAPK3 mitogen-activated protein kinase 3 1.238
TFF3 trefoil factor 3 (intestinal) 1.235
ALG8 ALG8, alpha-1,3-glucosyltransferase 1.234
AGXT2 alanine--glyoxylate aminotransferase 2 1.232
FGF3 fibroblast growth factor 3 1.232
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.232
ELN elastin 1.232
FGF18 fibroblast growth factor 18 1.23
FGF20 fibroblast growth factor 20 1.228
FGF9 fibroblast growth factor 9 1.228
APOE apolipoprotein E 1.228
NPHP1 nephronophthisis 1 (juvenile) 1.227
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 1.224
CA9 carbonic anhydrase IX 1.223
FGF16 fibroblast growth factor 16 1.223
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 1.219
GDA guanine deaminase 1.219
FGF17 fibroblast growth factor 17 1.219
MYH9 myosin, heavy chain 9, non-muscle 1.218
FGF22 fibroblast growth factor 22 1.217
FGF6 fibroblast growth factor 6 1.215
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 1.215
FGF4 fibroblast growth factor 4 1.215
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.214
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.213
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.211
CCND1 cyclin D1 1.21
FGF10 fibroblast growth factor 10 1.21
AOX1 aldehyde oxidase 1 1.21
LRP5 low density lipoprotein receptor-related protein 5 1.209
FAM111A family with sequence similarity 111, member A 1.209
CSH2 chorionic somatomammotropin hormone 2 1.208
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.208
JAK2 Janus kinase 2 1.206
PYY peptide YY 1.2
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.195
ANKH ANKH inorganic pyrophosphate transport regulator 1.194
DUOX1 dual oxidase 1 1.194
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 1.193
LYZL1 lysozyme-like 1 1.193
KHK ketohexokinase (fructokinase) 1.188
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.188
GLB1 galactosidase, beta 1 1.186
ESPN espin 1.186
TLR2 toll-like receptor 2 1.185
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 1.184
CRH corticotropin releasing hormone 1.183
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.181
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.178
TBL1X transducin (beta)-like 1X-linked 1.177
DUOX2 dual oxidase 2 1.175
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.175
MIOX myo-inositol oxygenase 1.174
MAOB monoamine oxidase B 1.172
FOS FBJ murine osteosarcoma viral oncogene homolog 1.169
NOX1 NADPH oxidase 1 1.168
TTR transthyretin 1.168
PROZ protein Z, vitamin K-dependent plasma glycoprotein 1.166
COL1A1 collagen, type I, alpha 1 1.165
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.164
SCT secretin 1.163
ADCK1 aarF domain containing kinase 1 1.159
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.159
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.158
PRKCSH protein kinase C substrate 80K-H 1.157
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 1.156
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.155
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.155
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.154
BDNF brain-derived neurotrophic factor 1.154
LOX lysyl oxidase 1.152
KCNK5 potassium channel, two pore domain subfamily K, member 5 1.15
NUMA1 nuclear mitotic apparatus protein 1 1.147
SUOX sulfite oxidase 1.147
GPX4 glutathione peroxidase 4 1.147
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.146
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1.146
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.143
DYTN dystrotelin 1.141
SLC38A3 solute carrier family 38, member 3 1.141
TXNIP thioredoxin interacting protein 1.14
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.139
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.138
FFAR2 free fatty acid receptor 2 1.137
BMP7 bone morphogenetic protein 7 1.135
FGFR1 fibroblast growth factor receptor 1 1.134
AMACR alpha-methylacyl-CoA racemase 1.133
INSR insulin receptor 1.133
AR androgen receptor 1.132
MAOA monoamine oxidase A 1.132
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.131
TRPC3 transient receptor potential cation channel, subfamily C, member 3 1.13
SHROOM3 shroom family member 3 1.13
ALPI alkaline phosphatase, intestinal 1.13
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.13
PLG plasminogen 1.128
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.127
STIM1 stromal interaction molecule 1 1.127
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 1.127
BECN1 beclin 1, autophagy related 1.126
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.125
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.124
HMGB1 high mobility group box 1 1.121
IL13 interleukin 13 1.119
MORN3 MORN repeat containing 3 1.117
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.116
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.115
MT1E metallothionein 1E 1.115
TPSAB1 tryptase alpha/beta 1 1.114
TSC2 tuberous sclerosis 2 1.113
GHRH growth hormone releasing hormone 1.113
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.113
SLC14A2 solute carrier family 14 (urea transporter), member 2 1.109
MYH14 myosin, heavy chain 14, non-muscle 1.106
RUMY2 RUMY family member 2 1.106
FGF21 fibroblast growth factor 21 1.105
CAV1 caveolin 1, caveolae protein, 22kDa 1.105
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.104
ALPP alkaline phosphatase, placental 1.102
VIP vasoactive intestinal peptide 1.1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 1.098
PAQR6 progestin and adipoQ receptor family member VI 1.097
AGTR1 angiotensin II receptor, type 1 1.096
CLDN1 claudin 1 1.095
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 1.093
EYA1 EYA transcriptional coactivator and phosphatase 1 1.093
G6PC3 glucose 6 phosphatase, catalytic, 3 1.092
VWF von Willebrand factor 1.091
NPPB natriuretic peptide B 1.089
TPO thyroid peroxidase 1.089
CCL5 chemokine (C-C motif) ligand 5 1.089
MSX2 msh homeobox 2 1.088
GSK3B glycogen synthase kinase 3 beta 1.086
TRPC1 transient receptor potential cation channel, subfamily C, member 1 1.085
SLC17A2 solute carrier family 17, member 2 1.085
AFP alpha-fetoprotein 1.084
NCAM1 neural cell adhesion molecule 1 1.083
GH1 growth hormone 1 1.083
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.082
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 1.081
NPPA natriuretic peptide A 1.08
GGCX gamma-glutamyl carboxylase 1.08
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 1.077
FFAR3 free fatty acid receptor 3 1.076
CTRB2 chymotrypsinogen B2 1.075
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 1.073
CBS cystathionine-beta-synthase 1.073
PRODH proline dehydrogenase (oxidase) 1 1.072
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 1.071
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 1.07
GSDMD gasdermin D 1.07
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.07
CTRB1 chymotrypsinogen B1 1.069
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 1.067
ZNF648 zinc finger protein 648 1.065
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.062
OCLN occludin 1.062
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.06
OXCT1 3-oxoacid CoA transferase 1 1.06
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.058
C4BPB complement component 4 binding protein, beta 1.058
TBC1D25 TBC1 domain family, member 25 1.055
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.055
PEX6 peroxisomal biogenesis factor 6 1.054
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.053
CLDN12 claudin 12 1.05
LYZ lysozyme 1.05
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.05
LPL lipoprotein lipase 1.049
CLDN7 claudin 7 1.049
TMEM67 transmembrane protein 67 1.048
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.047
ADA adenosine deaminase 1.046
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.045
FABP4 fatty acid binding protein 4, adipocyte 1.045
NGF nerve growth factor (beta polypeptide) 1.045
LIPF lipase, gastric 1.044
ADORA1 adenosine A1 receptor 1.043
TAC1 tachykinin, precursor 1 1.04
KRT8 keratin 8, type II 1.039
XPR1 xenotropic and polytropic retrovirus receptor 1 1.039
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 1.038
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.035
SCARB1 scavenger receptor class B, member 1 1.034
MTNR1B melatonin receptor 1B 1.033
PRR19 proline rich 19 1.031
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1.031
CD34 CD34 molecule 1.031
ANO1 anoctamin 1, calcium activated chloride channel 1.029
SLC22A18 solute carrier family 22, member 18 1.029
SOD2 superoxide dismutase 2, mitochondrial 1.028
HBB hemoglobin, beta 1.028
HAMP hepcidin antimicrobial peptide 1.027
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.025
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.024
TALDO1 transaldolase 1 1.023
POLG polymerase (DNA directed), gamma 1.021
S100A9 S100 calcium binding protein A9 1.02
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 1.018
SGK1 serum/glucocorticoid regulated kinase 1 1.018
CCN2 cellular communication network factor 2 1.016
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 1.015
PDE5A phosphodiesterase 5A, cGMP-specific 1.015
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.015
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.015
PTEN phosphatase and tensin homolog 1.015
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.014
EGFR epidermal growth factor receptor 1.013
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 1.012
CA4 carbonic anhydrase IV 1.011
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 1.011
TRIM8 tripartite motif containing 8 1.011
CTSK cathepsin K 1.011
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 1.01
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.01
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.009
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.009
ALPG alkaline phosphatase, germ cell 1.009
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 1.006
SDF4 stromal cell derived factor 4 1.006
PPIF peptidylprolyl isomerase F 1.006
IGFBP7 insulin-like growth factor binding protein 7 1.005
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.004
NKRF NFKB repressing factor 1.003
TFF2 trefoil factor 2 1.002
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 1.002
MOCS1 molybdenum cofactor synthesis 1 1.001
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 1.0