Nephrosclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

208 genes co-occuring with the disease Nephrosclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
REN renin 2.874
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.714
ALB albumin 2.675
ACE angiotensin I converting enzyme 2.674
APOL1 apolipoprotein L, 1 2.587
TGFB1 transforming growth factor, beta 1 2.252
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.246
MYH9 myosin, heavy chain 9, non-muscle 2.226
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.199
AGTR1 angiotensin II receptor, type 1 2.179
PTH parathyroid hormone 2.123
CRP C-reactive protein, pentraxin-related 2.082
EPO erythropoietin 2.054
CST3 cystatin C 2.044
KL klotho 2.012
UMOD uromodulin 2.007
SYNPO synaptopodin 1.964
FN1 fibronectin 1 1.948
HAVCR1 hepatitis A virus cellular receptor 1 1.945
FGF23 fibroblast growth factor 23 1.93
B2M beta-2-microglobulin 1.846
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.837
CCN2 cellular communication network factor 2 1.826
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.815
EDN1 endothelin 1 1.811
INS insulin 1.807
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.798
APOM apolipoprotein M 1.78
IL6 interleukin 6 1.765
ACTN4 actinin, alpha 4 1.699
LCN2 lipocalin 2 1.696
CCL2 chemokine (C-C motif) ligand 2 1.688
OGA O-GlcNAcase 1.68
SMAD3 SMAD family member 3 1.658
NOS3 nitric oxide synthase 3 (endothelial cell) 1.643
IL1B interleukin 1, beta 1.622
AQP2 aquaporin 2 (collecting duct) 1.62
SMAD7 SMAD family member 7 1.598
TNF tumor necrosis factor 1.59
PODXL podocalyxin-like 1.582
CD2AP CD2-associated protein 1.577
MPO myeloperoxidase 1.576
SMAD2 SMAD family member 2 1.567
NOX4 NADPH oxidase 4 1.559
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.535
AMBP alpha-1-microglobulin/bikunin precursor 1.531
FABP1 fatty acid binding protein 1, liver 1.53
BMP7 bone morphogenetic protein 7 1.517
RNLS renalase, FAD-dependent amine oxidase 1.513
GRK4 G protein-coupled receptor kinase 4 1.512
LRP2 low density lipoprotein receptor-related protein 2 1.512
SIRT1 sirtuin 1 1.508
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.505
PRTN3 proteinase 3 1.498
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.478
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.477
COL4A4 collagen, type IV, alpha 4 1.455
NPPA natriuretic peptide A 1.425
ACE2 angiotensin I converting enzyme 2 1.411
AGTR2 angiotensin II receptor, type 2 1.402
ICAM1 intercellular adhesion molecule 1 1.396
KNG1 kininogen 1 1.386
SHROOM3 shroom family member 3 1.379
C3 complement component 3 1.378
SPP1 secreted phosphoprotein 1 1.378
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.378
COL4A5 collagen, type IV, alpha 5 1.369
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.368
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.358
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.357
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.353
XDH xanthine dehydrogenase 1.351
CFHR5 complement factor H-related 5 1.35
CD4 CD4 molecule 1.342
WT1 Wilms tumor 1 1.34
SGK1 serum/glucocorticoid regulated kinase 1 1.334
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.334
IFNG interferon, gamma 1.322
PTPRO protein tyrosine phosphatase, receptor type, O 1.32
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.309
NPPB natriuretic peptide B 1.302
APOE apolipoprotein E 1.3
CD68 CD68 molecule 1.293
EDNRA endothelin receptor type A 1.293
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.293
PXDNL peroxidasin-like 1.291
VCAM1 vascular cell adhesion molecule 1 1.284
PXDN peroxidasin 1.283
APOL6 apolipoprotein L, 6 1.282
FRMD3 FERM domain containing 3 1.272
ADIPOQ adiponectin, C1Q and collagen domain containing 1.271
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.268
NCF1 neutrophil cytosolic factor 1 1.262
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.262
IL17A interleukin 17A 1.259
PPARG peroxisome proliferator-activated receptor gamma 1.259
MMP9 matrix metallopeptidase 9 1.252
TGFB2 transforming growth factor, beta 2 1.25
VWF von Willebrand factor 1.247
LEP leptin 1.245
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.244
CFH complement factor H 1.242
IGF1 insulin-like growth factor 1 (somatomedin C) 1.237
MYH14 myosin, heavy chain 14, non-muscle 1.236
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.232
MME membrane metallo-endopeptidase 1.231
DNAH8 dynein, axonemal, heavy chain 8 1.229
DPP4 dipeptidyl-peptidase 4 1.226
IL10 interleukin 10 1.226
IL18 interleukin 18 1.224
MMP2 matrix metallopeptidase 2 1.223
HAMP hepcidin antimicrobial peptide 1.211
KIRREL1 kirre like nephrin family adhesion molecule 1 1.188
DUOX2 dual oxidase 2 1.186
PLCE1 phospholipase C, epsilon 1 1.182
F3 coagulation factor III (thromboplastin, tissue factor) 1.18
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.18
ACTB actin, beta 1.177
TAGLN transgelin 1.177
TIMP1 TIMP metallopeptidase inhibitor 1 1.173
DUOX1 dual oxidase 1 1.171
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.17
TTC21B tetratricopeptide repeat domain 21B 1.169
PRKD1 protein kinase D1 1.167
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.164
ADRB1 adrenoceptor beta 1 1.157
CYBB cytochrome b-245, beta polypeptide 1.155
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.147
COL1A2 collagen, type I, alpha 2 1.146
CYBA cytochrome b-245, alpha polypeptide 1.145
ZEB2 zinc finger E-box binding homeobox 2 1.142
MMP7 matrix metallopeptidase 7 1.141
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.139
PECAM1 platelet/endothelial cell adhesion molecule 1 1.136
CD8A CD8a molecule 1.131
RHOA ras homolog family member A 1.131
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 1.131
TGFBR1 transforming growth factor, beta receptor 1 1.129
JUN jun proto-oncogene 1.126
EGF epidermal growth factor 1.123
AHSG alpha-2-HS-glycoprotein 1.118
DDAH2 dimethylarginine dimethylaminohydrolase 2 1.118
AVP arginine vasopressin 1.118
GPX3 glutathione peroxidase 3 1.117
PLG plasminogen 1.116
ELN elastin 1.115
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 1.113
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.112
DICER1 dicer 1, ribonuclease type III 1.11
DDAH1 dimethylarginine dimethylaminohydrolase 1 1.105
TGM2 transglutaminase 2 1.101
GLP1R glucagon-like peptide 1 receptor 1.097
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.094
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.094
EGLN2 egl-9 family hypoxia-inducible factor 2 1.093
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.092
COL4A1 collagen, type IV, alpha 1 1.089
TP53 tumor protein p53 1.088
RAMP3 receptor (G protein-coupled) activity modifying protein 3 1.087
COLEC11 collectin sub-family member 11 1.086
SIRT3 sirtuin 3 1.084
MAPK3 mitogen-activated protein kinase 3 1.081
S100A4 S100 calcium binding protein A4 1.075
POSTN periostin, osteoblast specific factor 1.074
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.071
GPX6 glutathione peroxidase 6 1.07
GPX2 glutathione peroxidase 2 1.07
GPX5 glutathione peroxidase 5 1.069
GPX8 glutathione peroxidase 8 (putative) 1.068
GPX7 glutathione peroxidase 7 1.065
SMAD4 SMAD family member 4 1.063
CCL5 chemokine (C-C motif) ligand 5 1.061
MMEL1 membrane metallo-endopeptidase-like 1 1.06
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.058
COQ6 coenzyme Q6 monooxygenase 1.058
PDGFB platelet-derived growth factor beta polypeptide 1.058
HMOX1 heme oxygenase 1 1.05
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.05
TMEM171 transmembrane protein 171 1.049
TLR4 toll-like receptor 4 1.048
PTGIS prostaglandin I2 (prostacyclin) synthase 1.045
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.045
DCN decorin 1.045
ADM adrenomedullin 1.044
AQP1 aquaporin 1 (Colton blood group) 1.043
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.041
KIAA0513 KIAA0513 1.037
CNKSR3 CNKSR family member 3 1.034
LMX1B LIM homeobox transcription factor 1, beta 1.031
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 1.03
TTR transthyretin 1.03
IL1A interleukin 1, alpha 1.03
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.03
CLDN1 claudin 1 1.026
NLRP3 NLR family, pyrin domain containing 3 1.021
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.019
CXCL8 chemokine (C-X-C motif) ligand 8 1.018
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.018
THSD7A thrombospondin, type I, domain containing 7A 1.016
SOD2 superoxide dismutase 2, mitochondrial 1.014
PPARA peroxisome proliferator-activated receptor alpha 1.011
ZEB1 zinc finger E-box binding homeobox 1 1.01
IL4 interleukin 4 1.004
DIDO1 death inducer-obliterator 1 1.004
NFE2L2 nuclear factor, erythroid 2-like 2 1.004
SMTN smoothelin 1.002
HLA-A major histocompatibility complex, class I, A 1.001
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.0