Neratinib (maleate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.17757
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.149937
CSTB cystatin B (stefin B) 0.141812
AHNAK2 AHNAK nucleoprotein 2 0.122471
AHNAK AHNAK nucleoprotein 0.11952
AKAP12 A kinase (PRKA) anchor protein 12 0.115634
CDH13 cadherin 13 0.114585
SLC39A11 solute carrier family 39, member 11 0.11271
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.110093
LOXL2 lysyl oxidase-like 2 0.106267
PODXL podocalyxin-like 0.0977939
PLAT plasminogen activator, tissue 0.0931453
TPM4 tropomyosin 4 0.0823253
SQSTM1 sequestosome 1 0.0709422
RNF213 ring finger protein 213 0.0650909
SH3KBP1 SH3-domain kinase binding protein 1 0.064269
TRIO trio Rho guanine nucleotide exchange factor 0.0631623
HDAC9 histone deacetylase 9 0.0573671
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0565079
PRELID2 PRELI domain containing 2 0.0551437
APP amyloid beta (A4) precursor protein 0.0538103
PBX3 pre-B-cell leukemia homeobox 3 0.0526761
LMNA lamin A/C 0.052141
MYOF myoferlin 0.0521286
PLEC plectin 0.0518571
TIMP2 TIMP metallopeptidase inhibitor 2 0.0515755
RSAD2 radical S-adenosyl methionine domain containing 2 0.0505967
ANKRD11 ankyrin repeat domain 11 0.050369
COL5A1 collagen, type V, alpha 1 0.0501342
RHOBTB3 Rho-related BTB domain containing 3 0.0500927
MAP1B microtubule-associated protein 1B 0.0500527
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0495517
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0489816
ASPH aspartate beta-hydroxylase 0.0488334
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0484586
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0483146
NFE2L1 nuclear factor, erythroid 2-like 1 0.0475027
MACF1 microtubule-actin crosslinking factor 1 0.0472956
FLNB filamin B, beta 0.0468757
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0459498
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0450135
NIBAN1 niban apoptosis regulator 1 0.0446385
MPRIP myosin phosphatase Rho interacting protein 0.0439643
EFNA5 ephrin-A5 0.0439052
CCND1 cyclin D1 0.0429852
TM4SF19 transmembrane 4 L six family member 19 0.0429522
ZMIZ1 zinc finger, MIZ-type containing 1 0.0424644
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0416529
SEPTIN9 septin 9 0.0414987
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0407703
EGFR epidermal growth factor receptor 0.0405609
ITGA6 integrin, alpha 6 0.0403216
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0394967
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0391497
DSG2 desmoglein 2 0.0383716
RND3 Rho family GTPase 3 0.0380234
CTSB cathepsin B 0.0378836
EZR ezrin 0.0376025
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0373264
SFTPA2 surfactant protein A2 0.0370831
AUTS2 autism susceptibility candidate 2 0.0366764
DSPP dentin sialophosphoprotein 0.0361888
SAMD9 sterile alpha motif domain containing 9 0.0351316
CAPN2 calpain 2, (m/II) large subunit 0.0349952
DST dystonin 0.0349915
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0330244
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0329117
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0320882
HLA-B major histocompatibility complex, class I, B 0.0319722
NAV1 neuron navigator 1 0.0317525
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0316893
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0316089
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0315153
ANK2 ankyrin 2, neuronal 0.031455
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0310827
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0309355
SYTL3 synaptotagmin-like 3 0.030885
L1CAM L1 cell adhesion molecule 0.0307038
LDHA lactate dehydrogenase A 0.0305672
TPM3 tropomyosin 3 0.0300184
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0298074
KIAA1549L KIAA1549-like 0.0297175
S100A10 S100 calcium binding protein A10 0.0297155
FLNA filamin A, alpha 0.0296895
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0296443
PKM pyruvate kinase, muscle 0.0294368
GARS1 glycyl-tRNA synthetase 1 0.0291488
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0291364
TRAM2 translocation associated membrane protein 2 0.0291053
TBC1D5 TBC1 domain family, member 5 0.0291034
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0290473
NUPR1 nuclear protein, transcriptional regulator, 1 0.0289556
RAD51B RAD51 paralog B 0.0285896
MARCHF4 membrane associated ring-CH-type finger 4 0.0284269
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0281561
KLF6 Kruppel-like factor 6 0.028146
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0279575
S100A11 S100 calcium binding protein A11 0.0279532
BACE2 beta-site APP-cleaving enzyme 2 0.0278815
IFITM1 interferon induced transmembrane protein 1 0.0278418

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.16073
LOX lysyl oxidase -0.142511
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.141705
UBC ubiquitin C -0.118441
COL8A1 collagen, type VIII, alpha 1 -0.117455
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.105737
FBN1 fibrillin 1 -0.101751
TMSB10 thymosin beta 10 -0.0918648
COL3A1 collagen, type III, alpha 1 -0.077239
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0763054
SOD2 superoxide dismutase 2, mitochondrial -0.0714028
COL5A2 collagen, type V, alpha 2 -0.0701665
PTMA prothymosin, alpha -0.0649811
FNDC3B fibronectin type III domain containing 3B -0.0639606
GLIS3 GLIS family zinc finger 3 -0.0511512
COL1A2 collagen, type I, alpha 2 -0.0504881
VIM vimentin -0.0489618
KIFAP3 kinesin-associated protein 3 -0.0444617
ARL15 ADP-ribosylation factor-like 15 -0.0410076
NAP1L1 nucleosome assembly protein 1-like 1 -0.0407613
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.03876
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.038294
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0375514
GLS2 glutaminase 2 (liver, mitochondrial) -0.0372341
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0367219
RPS27A ribosomal protein S27a -0.0357092
OGA O-GlcNAcase -0.0355827
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0347213
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0346048
IGFBP3 insulin-like growth factor binding protein 3 -0.0345472
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0345185
COPA coatomer protein complex, subunit alpha -0.0326828
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0324171
DPYSL3 dihydropyrimidinase-like 3 -0.0322621
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0315178
FRMD4A FERM domain containing 4A -0.0313022
DENND5A DENN/MADD domain containing 5A -0.0312699
PSD3 pleckstrin and Sec7 domain containing 3 -0.030177
RAI14 retinoic acid induced 14 -0.0298937
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0289643
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0282354
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0280338
TPST1 tyrosylprotein sulfotransferase 1 -0.0263837
CYLD cylindromatosis (turban tumor syndrome) -0.0263084
ANKRD10 ankyrin repeat domain 10 -0.0259245
MEIS2 Meis homeobox 2 -0.0256506
FTH1 ferritin, heavy polypeptide 1 -0.0253606
FRMD5 FERM domain containing 5 -0.0252168
TM4SF1 transmembrane 4 L six family member 1 -0.0252092
HLA-E major histocompatibility complex, class I, E -0.024757
ATP13A3 ATPase type 13A3 -0.0246968
VMP1 vacuole membrane protein 1 -0.0238689
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.023032
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0229585
ZNF207 zinc finger protein 207 -0.0229247
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.022912
CDK6 cyclin-dependent kinase 6 -0.0224088
TNS3 tensin 3 -0.0224012
TPT1 tumor protein, translationally-controlled 1 -0.0223785
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.022341
TTC3 tetratricopeptide repeat domain 3 -0.0218147
DLG1 discs, large homolog 1 (Drosophila) -0.0216324
NT5C2 5'-nucleotidase, cytosolic II -0.0216144
NEK7 NIMA-related kinase 7 -0.021113
PRRX1 paired related homeobox 1 -0.0210284
ACBD3 acyl-CoA binding domain containing 3 -0.0210224
SPAG9 sperm associated antigen 9 -0.0208918
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0208293
MBNL2 muscleblind-like splicing regulator 2 -0.020815
KDM3A lysine (K)-specific demethylase 3A -0.0207854
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0206697
CHD9 chromodomain helicase DNA binding protein 9 -0.0204335
HMGB2 high mobility group box 2 -0.0204333
TBC1D23 TBC1 domain family, member 23 -0.0199753
SUCO SUN domain containing ossification factor -0.0198713
TMEM263 transmembrane protein 263 -0.0197468
TNIP1 TNFAIP3 interacting protein 1 -0.0196096
FNIP1 folliculin interacting protein 1 -0.0194643
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.019056
EHBP1 EH domain binding protein 1 -0.0189409
SEC31A SEC31 homolog A (S. cerevisiae) -0.0188235
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0186067
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0186001
HIP1 huntingtin interacting protein 1 -0.018576
LRRC49 leucine rich repeat containing 49 -0.0185558
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.01851
TMOD1 tropomodulin 1 -0.0185031
ZFC3H1 zinc finger, C3H1-type containing -0.0184129
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.018295
MRTFA myocardin related transcription factor A -0.0182296
RAB1A RAB1A, member RAS oncogene family -0.0179801
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0176944
ARSJ arylsulfatase family, member J -0.01766
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0172645
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0172014
WTAP Wilms tumor 1 associated protein -0.0171234
MRPS6 mitochondrial ribosomal protein S6 -0.0169179
COL27A1 collagen, type XXVII, alpha 1 -0.0168955
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0168599
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0163616