| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.215108 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.131682 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.105013 |
| TXNRD1 | thioredoxin reductase 1 | 0.102569 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0972108 |
| TMEM41B | transmembrane protein 41B | 0.0778558 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0671763 |
| RTN4 | reticulon 4 | 0.0643883 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0633736 |
| JMJD1C | jumonji domain containing 1C | 0.0615532 |
| VMP1 | vacuole membrane protein 1 | 0.0601126 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0593141 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.057958 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0541021 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0493912 |
| ANK2 | ankyrin 2, neuronal | 0.0433125 |
| PCBP2 | poly(rC) binding protein 2 | 0.0411319 |
| EZR | ezrin | 0.0409295 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0407729 |
| MMP12 | matrix metallopeptidase 12 | 0.038297 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0377925 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0368819 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0365907 |
| VIM | vimentin | 0.0347674 |
| PRKCI | protein kinase C, iota | 0.0338142 |
| SQSTM1 | sequestosome 1 | 0.0336499 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0329612 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0303045 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0300542 |
| UBC | ubiquitin C | 0.0292374 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0291357 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0286427 |
| SESN2 | sestrin 2 | 0.0278972 |
| IL6ST | interleukin 6 signal transducer | 0.0278772 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0276465 |
| TBK1 | TANK-binding kinase 1 | 0.0276276 |
| ANXA1 | annexin A1 | 0.0266312 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0265676 |
| KIF1B | kinesin family member 1B | 0.0261847 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0257017 |
| MAP1B | microtubule-associated protein 1B | 0.024285 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.023677 |
| XPO1 | exportin 1 | 0.023663 |
| MATR3 | matrin 3 | 0.0236403 |
| POTEF | POTE ankyrin domain family, member F | 0.0232391 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0230969 |
| THOC1 | THO complex 1 | 0.0230554 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0228627 |
| IPO7 | importin 7 | 0.0228205 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0227341 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0225603 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0225554 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0222879 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.022091 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0218301 |
| CALR | calreticulin | 0.0217551 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0216429 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0214441 |
| CDK19 | cyclin-dependent kinase 19 | 0.0214027 |
| HELB | helicase (DNA) B | 0.0212291 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0211776 |
| KLC1 | kinesin light chain 1 | 0.0210207 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0209777 |
| CEP70 | centrosomal protein 70kDa | 0.0209776 |
| KIF5B | kinesin family member 5B | 0.0208435 |
| CEP95 | centrosomal protein 95kDa | 0.0207994 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.020754 |
| CPOX | coproporphyrinogen oxidase | 0.0205836 |
| CEP192 | centrosomal protein 192kDa | 0.0204404 |
| FDPS | farnesyl diphosphate synthase | 0.0203323 |
| TPD52 | tumor protein D52 | 0.0202556 |
| AAK1 | AP2 associated kinase 1 | 0.0202184 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0199299 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0199086 |
| PCM1 | pericentriolar material 1 | 0.0196573 |
| DOCK3 | dedicator of cytokinesis 3 | 0.019595 |
| ATP11B | ATPase, class VI, type 11B | 0.0195934 |
| VGLL4 | vestigial-like family member 4 | 0.0195146 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0193509 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0193015 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0192961 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0190864 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0187075 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0186895 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0185214 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0183822 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0181707 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.0181554 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0181318 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0181235 |
| CD164 | CD164 molecule, sialomucin | 0.0180958 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0179523 |
| CCNY | cyclin Y | 0.0178084 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0177781 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0177532 |
| PUM2 | pumilio RNA-binding family member 2 | 0.017684 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0176249 |
| PREPL | prolyl endopeptidase-like | 0.0175897 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0173722 |
| NEK7 | NIMA-related kinase 7 | 0.0172446 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.153551 |
| TMSB10 | thymosin beta 10 | -0.138897 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.130882 |
| HMGA2 | high mobility group AT-hook 2 | -0.115481 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.115028 |
| EHBP1 | EH domain binding protein 1 | -0.0764941 |
| RPS12 | ribosomal protein S12 | -0.0732091 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0661748 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0622316 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.061669 |
| ASPH | aspartate beta-hydroxylase | -0.0545059 |
| RPL37A | ribosomal protein L37a | -0.0520605 |
| ACTG1 | actin gamma 1 | -0.051182 |
| TENM3 | teneurin transmembrane protein 3 | -0.0511666 |
| INTS6 | integrator complex subunit 6 | -0.0510973 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0505851 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0504945 |
| ZNF804A | zinc finger protein 804A | -0.048256 |
| RPL23 | ribosomal protein L23 | -0.0471324 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0468128 |
| MTAP | methylthioadenosine phosphorylase | -0.0463739 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0445774 |
| RPL9 | ribosomal protein L9 | -0.0435709 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0416143 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0415231 |
| RPS3 | ribosomal protein S3 | -0.0405019 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0400569 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0397129 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0386045 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0377089 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0374982 |
| RPL12 | ribosomal protein L12 | -0.0369377 |
| RPS19 | ribosomal protein S19 | -0.0369168 |
| PCDH7 | protocadherin 7 | -0.0369086 |
| HDAC9 | histone deacetylase 9 | -0.0360105 |
| NEBL | nebulette | -0.0352863 |
| RPS27A | ribosomal protein S27a | -0.0349976 |
| NHSL1 | NHS-like 1 | -0.0349252 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0318942 |
| MGAT4C | MGAT4 family, member C | -0.0316758 |
| PTMA | prothymosin, alpha | -0.0315907 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.03129 |
| ADIPOR2 | adiponectin receptor 2 | -0.0309825 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0305954 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0301198 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0300828 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0298787 |
| RPL26 | ribosomal protein L26 | -0.029551 |
| EGR1 | early growth response 1 | -0.0286016 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0279353 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0275797 |
| SYT1 | synaptotagmin I | -0.0272015 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0262652 |
| FTL | ferritin, light polypeptide | -0.0261283 |
| AEBP2 | AE binding protein 2 | -0.026061 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.025435 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.024849 |
| RPL31 | ribosomal protein L31 | -0.0245548 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0244314 |
| RNF213 | ring finger protein 213 | -0.0238933 |
| RPL37 | ribosomal protein L37 | -0.0238646 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.023583 |
| LRRC23 | leucine rich repeat containing 23 | -0.023243 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0228902 |
| FSTL5 | follistatin-like 5 | -0.0228315 |
| RPS8 | ribosomal protein S8 | -0.0225696 |
| COMMD10 | COMM domain containing 10 | -0.0224956 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0224516 |
| RPL36 | ribosomal protein L36 | -0.0224105 |
| NUP98 | nucleoporin 98kDa | -0.0220155 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0220089 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0219848 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0218843 |
| RPL11 | ribosomal protein L11 | -0.0218366 |
| TBCA | tubulin folding cofactor A | -0.0215137 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0211475 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.02089 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.020778 |
| UBAP2 | ubiquitin associated protein 2 | -0.0205736 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0204235 |
| CDK6 | cyclin-dependent kinase 6 | -0.0202491 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0196233 |
| YAP1 | Yes-associated protein 1 | -0.0195547 |
| DENND5A | DENN/MADD domain containing 5A | -0.0194436 |
| TMEM108 | transmembrane protein 108 | -0.0193593 |
| CUX1 | cut-like homeobox 1 | -0.0191114 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0190649 |
| PHF14 | PHD finger protein 14 | -0.0190331 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0190037 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0189196 |
| PDGFC | platelet derived growth factor C | -0.0189035 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.018902 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0188624 |
| CMIP | c-Maf inducing protein | -0.0187172 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0187026 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0186236 |
| PRDX1 | peroxiredoxin 1 | -0.0182852 |
| RPL5 | ribosomal protein L5 | -0.0182099 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0180747 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0180374 |
