| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib (maleate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.322556 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.129615 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.114351 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.110668 |
| ASPH | aspartate beta-hydroxylase | 0.103224 |
| TXNRD1 | thioredoxin reductase 1 | 0.0934379 |
| TUSC3 | tumor suppressor candidate 3 | 0.08943 |
| NFIB | nuclear factor I/B | 0.0774742 |
| HDAC9 | histone deacetylase 9 | 0.0729864 |
| SMAD3 | SMAD family member 3 | 0.0711648 |
| EXOC4 | exocyst complex component 4 | 0.0706091 |
| EFNA5 | ephrin-A5 | 0.067748 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0664034 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0626838 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0612487 |
| NAV2 | neuron navigator 2 | 0.0603664 |
| RND3 | Rho family GTPase 3 | 0.0583732 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0566734 |
| APP | amyloid beta (A4) precursor protein | 0.0551094 |
| B2M | beta-2-microglobulin | 0.0549968 |
| TPM3 | tropomyosin 3 | 0.053022 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0523157 |
| PLK2 | polo-like kinase 2 | 0.0513531 |
| FMNL2 | formin-like 2 | 0.0506787 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.050236 |
| GLIS3 | GLIS family zinc finger 3 | 0.047599 |
| VEGFA | vascular endothelial growth factor A | 0.0474116 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0461687 |
| LOXL2 | lysyl oxidase-like 2 | 0.045749 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0456619 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.04544 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0453884 |
| PCBP2 | poly(rC) binding protein 2 | 0.0441711 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0424762 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0424617 |
| PLIN2 | perilipin 2 | 0.041405 |
| RAB10 | RAB10, member RAS oncogene family | 0.041278 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0411135 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0400818 |
| SLC35F3 | solute carrier family 35, member F3 | 0.039603 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0389463 |
| RNF213 | ring finger protein 213 | 0.0382302 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0379398 |
| PAX8 | paired box 8 | 0.0377373 |
| ANK2 | ankyrin 2, neuronal | 0.0374756 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0373562 |
| SQSTM1 | sequestosome 1 | 0.0369978 |
| PHF14 | PHD finger protein 14 | 0.0369234 |
| EGFR | epidermal growth factor receptor | 0.0368452 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0367847 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0359179 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.035856 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0358133 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0357683 |
| ANKRD11 | ankyrin repeat domain 11 | 0.035303 |
| NRP2 | neuropilin 2 | 0.035251 |
| FTL | ferritin, light polypeptide | 0.035212 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0351901 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.035043 |
| KYNU | kynureninase | 0.0345418 |
| FNDC3B | fibronectin type III domain containing 3B | 0.034494 |
| FRMD5 | FERM domain containing 5 | 0.0341928 |
| SRPK2 | SRSF protein kinase 2 | 0.0336371 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0330282 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0328535 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0322362 |
| MSN | moesin | 0.0321661 |
| MAP1B | microtubule-associated protein 1B | 0.0321656 |
| HKDC1 | hexokinase domain containing 1 | 0.03196 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0319193 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0317742 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0317553 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0313746 |
| ZNF462 | zinc finger protein 462 | 0.0312494 |
| RPL3 | ribosomal protein L3 | 0.0311729 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0310073 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0306657 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0303844 |
| SET | SET nuclear proto-oncogene | 0.0303177 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0303109 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0301753 |
| EHBP1 | EH domain binding protein 1 | 0.0299402 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0296547 |
| SEPTIN9 | septin 9 | 0.0296421 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0295265 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0293507 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0292292 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0287785 |
| ERBIN | erbb2 interacting protein | 0.0287342 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0284706 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0283068 |
| SMYD3 | SET and MYND domain containing 3 | 0.027826 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0271578 |
| TGFB2 | transforming growth factor, beta 2 | 0.0270025 |
| CMIP | c-Maf inducing protein | 0.0268686 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 0.0266799 |
| ZNF148 | zinc finger protein 148 | 0.0266152 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.026284 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0262624 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0260865 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.178161 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.152074 |
| VIM | vimentin | -0.15078 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.1024 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.084785 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0778412 |
| CP | ceruloplasmin (ferroxidase) | -0.0740573 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0726231 |
| CD44 | CD44 molecule (Indian blood group) | -0.0725986 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0654099 |
| RRBP1 | ribosome binding protein 1 | -0.0647055 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0642505 |
| SPAG9 | sperm associated antigen 9 | -0.0567859 |
| TMSB10 | thymosin beta 10 | -0.0550271 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0515752 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0515697 |
| HLA-B | major histocompatibility complex, class I, B | -0.0503019 |
| FRMD4A | FERM domain containing 4A | -0.0492022 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0445563 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0427831 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.0409306 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0404451 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0398551 |
| CD82 | CD82 molecule | -0.0395853 |
| MT2A | metallothionein 2A | -0.0384968 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0380493 |
| ACTG1 | actin gamma 1 | -0.0377082 |
| TMEM263 | transmembrane protein 263 | -0.0366123 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0364616 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0362236 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0358856 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0358098 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0357379 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0354813 |
| ARF1 | ADP-ribosylation factor 1 | -0.0353904 |
| CADM1 | cell adhesion molecule 1 | -0.03529 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0348789 |
| RPS24 | ribosomal protein S24 | -0.0344763 |
| FUS | FUS RNA binding protein | -0.034445 |
| RPL35A | ribosomal protein L35a | -0.0341821 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0330258 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0325747 |
| CAVIN1 | caveolae associated protein 1 | -0.0324288 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0322684 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0322139 |
| DGKI | diacylglycerol kinase, iota | -0.0321563 |
| PTMA | prothymosin, alpha | -0.032065 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0318058 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0308865 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0300467 |
| RPL34 | ribosomal protein L34 | -0.0294843 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0289361 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0287856 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0284942 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0283373 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0281898 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0281293 |
| ANLN | anillin, actin binding protein | -0.0278642 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0277137 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0274078 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0272643 |
| GNAS | GNAS complex locus | -0.0269361 |
| SEC24D | SEC24 family member D | -0.0269061 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0267642 |
| RIGI | RNA sensor RIG-I | -0.0267001 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0266895 |
| PRRC1 | proline-rich coiled-coil 1 | -0.026234 |
| FN1 | fibronectin 1 | -0.0259329 |
| DENND4A | DENN/MADD domain containing 4A | -0.0259318 |
| RPS21 | ribosomal protein S21 | -0.0258303 |
| SRP72 | signal recognition particle 72kDa | -0.0257576 |
| INSIG1 | insulin induced gene 1 | -0.0255527 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0254855 |
| VCAN | versican | -0.025483 |
| IL6ST | interleukin 6 signal transducer | -0.0249283 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0248844 |
| PXDN | peroxidasin | -0.0248692 |
| HLA-E | major histocompatibility complex, class I, E | -0.0247934 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0247927 |
| COG6 | component of oligomeric golgi complex 6 | -0.024747 |
| HDLBP | high density lipoprotein binding protein | -0.0246888 |
| HMGB1 | high mobility group box 1 | -0.0244735 |
| SEPTIN7 | septin 7 | -0.024199 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0240926 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0240267 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0237442 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0236157 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0235341 |
| RAB2A | RAB2A, member RAS oncogene family | -0.023526 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0233653 |
| STK17A | serine/threonine kinase 17a | -0.0232968 |
| GOLGA4 | golgin A4 | -0.0230849 |
| MORF4L2 | mortality factor 4 like 2 | -0.0230405 |
| SDCBP | syndecan binding protein (syntenin) | -0.0229527 |
| G0S2 | G0/G1 switch 2 | -0.0227858 |
| MMP7 | matrix metallopeptidase 7 | -0.0227158 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0226909 |
| IER3 | immediate early response 3 | -0.0226147 |
| TPM4 | tropomyosin 4 | -0.0226067 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0225732 |
