| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.199873 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.12388 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.113927 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0876816 |
| EFNA5 | ephrin-A5 | 0.085403 |
| MCL1 | myeloid cell leukemia 1 | 0.0852946 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0847266 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0795982 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0696508 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0604572 |
| DOCK5 | dedicator of cytokinesis 5 | 0.058145 |
| PCBP2 | poly(rC) binding protein 2 | 0.0535725 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0507076 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0482264 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0476028 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0464891 |
| POTEF | POTE ankyrin domain family, member F | 0.0450342 |
| FLNB | filamin B, beta | 0.0425716 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.042473 |
| STC1 | stanniocalcin 1 | 0.0421047 |
| AXL | AXL receptor tyrosine kinase | 0.0414905 |
| MSN | moesin | 0.0408563 |
| EGFR | epidermal growth factor receptor | 0.0403742 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0333706 |
| AUTS2 | autism susceptibility candidate 2 | 0.0325184 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0320338 |
| LOXL2 | lysyl oxidase-like 2 | 0.0315346 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0311839 |
| LAMC2 | laminin, gamma 2 | 0.029964 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.029323 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0292225 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0283441 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0275926 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0275826 |
| MYADM | myeloid-associated differentiation marker | 0.0274624 |
| HMGA2 | high mobility group AT-hook 2 | 0.0259967 |
| ZFP36 | ZFP36 ring finger protein | 0.0256766 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0247401 |
| TNS1 | tensin 1 | 0.0242576 |
| TGM2 | transglutaminase 2 | 0.0242546 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0238967 |
| PYGL | phosphorylase, glycogen, liver | 0.0238827 |
| RND3 | Rho family GTPase 3 | 0.0238207 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.023755 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0230429 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0228986 |
| LAMA5 | laminin, alpha 5 | 0.0228571 |
| EZR | ezrin | 0.0227551 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0221403 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0220413 |
| DUSP16 | dual specificity phosphatase 16 | 0.0219427 |
| BMP6 | bone morphogenetic protein 6 | 0.0217502 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0217391 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0215825 |
| CCDC88A | coiled-coil domain containing 88A | 0.0213435 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0213367 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.020035 |
| TPM1 | tropomyosin 1 (alpha) | 0.0199714 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0197614 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0197233 |
| RAD51B | RAD51 paralog B | 0.0195582 |
| RHCG | Rh family, C glycoprotein | 0.0192304 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.0185632 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0184556 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0179492 |
| DSPP | dentin sialophosphoprotein | 0.0179485 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0179075 |
| USP47 | ubiquitin specific peptidase 47 | 0.0178366 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0176933 |
| FRMD6 | FERM domain containing 6 | 0.0173842 |
| MYO10 | myosin X | 0.0172162 |
| TCIM | transcriptional and immune response regulator | 0.0170139 |
| DAPK1 | death-associated protein kinase 1 | 0.0169881 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0169706 |
| TPM4 | tropomyosin 4 | 0.0169337 |
| MYO1E | myosin IE | 0.0167162 |
| VEGFA | vascular endothelial growth factor A | 0.0163632 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.015957 |
| PLEC | plectin | 0.0159287 |
| FAM13A | family with sequence similarity 13, member A | 0.0159161 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0157427 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0154811 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0154542 |
| BCL2L1 | BCL2-like 1 | 0.0151339 |
| ATXN1 | ataxin 1 | 0.0149549 |
| RPL3 | ribosomal protein L3 | 0.0149358 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0149232 |
| MAP7 | microtubule-associated protein 7 | 0.0149058 |
| RIN2 | Ras and Rab interactor 2 | 0.0145801 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0144318 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0143595 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0143078 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0141368 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0140596 |
| EGR1 | early growth response 1 | 0.0139427 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0139247 |
| FOXP1 | forkhead box P1 | 0.0137598 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0137259 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0137184 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0136638 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.16519 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.16042 |
| FTL | ferritin, light polypeptide | -0.115595 |
| RPS19 | ribosomal protein S19 | -0.0862952 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0812053 |
| MT2A | metallothionein 2A | -0.0793419 |
| ACTG1 | actin gamma 1 | -0.0756479 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0747851 |
| PTMA | prothymosin, alpha | -0.0745798 |
| RPLP1 | ribosomal protein, large, P1 | -0.0643999 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0637874 |
| RPS24 | ribosomal protein S24 | -0.060956 |
| RPL23 | ribosomal protein L23 | -0.0581405 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0562621 |
| RPS16 | ribosomal protein S16 | -0.0531861 |
| RPL26 | ribosomal protein L26 | -0.0520243 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0495717 |
| RPS6 | ribosomal protein S6 | -0.049187 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.046833 |
| SPAG9 | sperm associated antigen 9 | -0.044391 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0438442 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0429791 |
| RPL19 | ribosomal protein L19 | -0.0427714 |
| KRT81 | keratin 81, type II | -0.0427461 |
| RPL12 | ribosomal protein L12 | -0.0422127 |
| RPS27A | ribosomal protein S27a | -0.0405145 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0404527 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0393669 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0390413 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0384282 |
| RRBP1 | ribosome binding protein 1 | -0.0383915 |
| USP3 | ubiquitin specific peptidase 3 | -0.0378636 |
| RPL37A | ribosomal protein L37a | -0.0372869 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0370759 |
| RPS8 | ribosomal protein S8 | -0.0368197 |
| NCOA7 | nuclear receptor coactivator 7 | -0.036504 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.036434 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0360288 |
| RPL32 | ribosomal protein L32 | -0.0359102 |
| MORF4L2 | mortality factor 4 like 2 | -0.0358296 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0353931 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0352543 |
| HELZ | helicase with zinc finger | -0.0351448 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0350903 |
| RPLP2 | ribosomal protein, large, P2 | -0.0349863 |
| RPL4 | ribosomal protein L4 | -0.0346707 |
| GOLGA4 | golgin A4 | -0.0343151 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0337471 |
| RPL35A | ribosomal protein L35a | -0.0334997 |
| RPS3 | ribosomal protein S3 | -0.0334883 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0334177 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0333243 |
| SBF2 | SET binding factor 2 | -0.0332909 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0329246 |
| MT1X | metallothionein 1X | -0.0327921 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.03262 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0322733 |
| RPL13A | ribosomal protein L13a | -0.0319889 |
| OGA | O-GlcNAcase | -0.0318949 |
| RACK1 | receptor for activated C kinase 1 | -0.0315739 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0314368 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0312669 |
| RPS21 | ribosomal protein S21 | -0.0312397 |
| RPL38 | ribosomal protein L38 | -0.0309241 |
| RPS11 | ribosomal protein S11 | -0.0308198 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0307906 |
| S100A10 | S100 calcium binding protein A10 | -0.0307842 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0302155 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0299706 |
| RPL8 | ribosomal protein L8 | -0.0299085 |
| VIM | vimentin | -0.0298688 |
| RPL11 | ribosomal protein L11 | -0.0296021 |
| TMSB4X | thymosin beta 4, X-linked | -0.0295778 |
| RPS5 | ribosomal protein S5 | -0.0295584 |
| RPLP0 | ribosomal protein, large, P0 | -0.0294241 |
| TXNRD1 | thioredoxin reductase 1 | -0.0290972 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0286802 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0281883 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0281233 |
| RPS13 | ribosomal protein S13 | -0.0279318 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0278092 |
| RPS23 | ribosomal protein S23 | -0.0275617 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0275578 |
| RPL31 | ribosomal protein L31 | -0.0273501 |
| RPL28 | ribosomal protein L28 | -0.0273132 |
| PGK1 | phosphoglycerate kinase 1 | -0.0269993 |
| TKT | transketolase | -0.0268964 |
| RPS4X | ribosomal protein S4, X-linked | -0.0267625 |
| CEP95 | centrosomal protein 95kDa | -0.0267543 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0266936 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0264127 |
| RPL7A | ribosomal protein L7a | -0.0262191 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0259744 |
| RPL34 | ribosomal protein L34 | -0.0259196 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0256785 |
| ANXA2 | annexin A2 | -0.0256184 |
| SEPTIN2 | septin 2 | -0.0256095 |
| RPL37 | ribosomal protein L37 | -0.0250203 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0249692 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.02441 |
