| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.212567 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.160486 |
| NDRG1 | N-myc downstream regulated 1 | 0.149281 |
| FLNB | filamin B, beta | 0.113051 |
| TPM3 | tropomyosin 3 | 0.0881961 |
| EZR | ezrin | 0.08342 |
| PCBP2 | poly(rC) binding protein 2 | 0.0792862 |
| PLEC | plectin | 0.0756383 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.069542 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0686581 |
| DSPP | dentin sialophosphoprotein | 0.0667172 |
| TXNRD1 | thioredoxin reductase 1 | 0.0650996 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0590583 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0586227 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0575376 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0557317 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0535082 |
| SMAD3 | SMAD family member 3 | 0.0511149 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0505721 |
| EFNA5 | ephrin-A5 | 0.0457258 |
| ASPH | aspartate beta-hydroxylase | 0.0453139 |
| RPS12 | ribosomal protein S12 | 0.0446676 |
| TGM2 | transglutaminase 2 | 0.0435941 |
| AHNAK | AHNAK nucleoprotein | 0.0422177 |
| RPS3 | ribosomal protein S3 | 0.041374 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0413224 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0406062 |
| MSN | moesin | 0.0395573 |
| RPS18 | ribosomal protein S18 | 0.0390146 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0388921 |
| SEPTIN9 | septin 9 | 0.0378394 |
| MCL1 | myeloid cell leukemia 1 | 0.0367914 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.03658 |
| PKM | pyruvate kinase, muscle | 0.0365557 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.035936 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0358895 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.035649 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0354084 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0351081 |
| RPS2 | ribosomal protein S2 | 0.0345358 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0340893 |
| HMGA1 | high mobility group AT-hook 1 | 0.0326385 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0325658 |
| CD44 | CD44 molecule (Indian blood group) | 0.0325033 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0318606 |
| FHL2 | four and a half LIM domains 2 | 0.0313621 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0313224 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0311933 |
| APP | amyloid beta (A4) precursor protein | 0.0300606 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0299948 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0297648 |
| MUC17 | mucin 17, cell surface associated | 0.0292308 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0291604 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0288644 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0287757 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0284134 |
| VIM | vimentin | 0.0277227 |
| ENO1 | enolase 1, (alpha) | 0.0276254 |
| LDHA | lactate dehydrogenase A | 0.0271072 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0270243 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0265466 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0262915 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.026208 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0260407 |
| PRELID2 | PRELI domain containing 2 | 0.0256951 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0251314 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0250029 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0246054 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0245262 |
| FMNL2 | formin-like 2 | 0.0244536 |
| RPL3 | ribosomal protein L3 | 0.0243053 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0242514 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0242082 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0241996 |
| RUNX1 | runt-related transcription factor 1 | 0.0241812 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0241366 |
| OSBP2 | oxysterol binding protein 2 | 0.0240029 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.023876 |
| DIAPH1 | diaphanous-related formin 1 | 0.0236681 |
| CDCP1 | CUB domain containing protein 1 | 0.0233162 |
| VEGFA | vascular endothelial growth factor A | 0.0229075 |
| SACK1B | scaffolding CK1 anchoring protein B | 0.0222171 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0215438 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0214717 |
| RACK1 | receptor for activated C kinase 1 | 0.0209675 |
| SET | SET nuclear proto-oncogene | 0.0208914 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0206454 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0205045 |
| ATP13A3 | ATPase type 13A3 | 0.0204879 |
| RTEL1 | regulator of telomere elongation helicase 1 | 0.0204537 |
| RAI14 | retinoic acid induced 14 | 0.0203771 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0200727 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0199974 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0199542 |
| RPL37A | ribosomal protein L37a | 0.0199276 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0194047 |
| CAB39 | calcium binding protein 39 | 0.0192665 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0188203 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0185039 |
| RPS27 | ribosomal protein S27 | 0.0182337 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.165509 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.150422 |
| LMO7 | LIM domain 7 | -0.137583 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.12185 |
| KLK10 | kallikrein-related peptidase 10 | -0.11666 |
| LAMB3 | laminin, beta 3 | -0.101447 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0990987 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0959125 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0816369 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0790209 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0756598 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0696813 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0621703 |
| TMSB10 | thymosin beta 10 | -0.0605354 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.059959 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0578148 |
| S100A10 | S100 calcium binding protein A10 | -0.054891 |
| S100A4 | S100 calcium binding protein A4 | -0.0536955 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0535514 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0527734 |
| SP100 | SP100 nuclear antigen | -0.0524127 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0505532 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0488441 |
| RPL35A | ribosomal protein L35a | -0.048602 |
| RPS24 | ribosomal protein S24 | -0.046941 |
| RPS21 | ribosomal protein S21 | -0.046101 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0457288 |
| RPL34 | ribosomal protein L34 | -0.0447571 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0447127 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0446425 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0443361 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0443231 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0442744 |
| TMEM263 | transmembrane protein 263 | -0.0441253 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0413712 |
| CD2AP | CD2-associated protein | -0.0409714 |
| COG5 | component of oligomeric golgi complex 5 | -0.0407336 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0396966 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0396077 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0393716 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0393587 |
| NPSR1 | neuropeptide S receptor 1 | -0.0390868 |
| RRBP1 | ribosome binding protein 1 | -0.0390707 |
| CALU | calumenin | -0.0389395 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0384848 |
| GNAS | GNAS complex locus | -0.0383632 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0378974 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0377754 |
| ARF4 | ADP-ribosylation factor 4 | -0.0375801 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0368879 |
| PERP | PERP, TP53 apoptosis effector | -0.0362474 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0359923 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0351829 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0346072 |
| GOLGA4 | golgin A4 | -0.0345726 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0345268 |
| FBXO11 | F-box protein 11 | -0.0344734 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0342105 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0331176 |
| FUS | FUS RNA binding protein | -0.0328024 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0324657 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0324531 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0321121 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0320225 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0315832 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0313996 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0312616 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0311174 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0310417 |
| PTMA | prothymosin, alpha | -0.030674 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0300067 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0299106 |
| CLINT1 | clathrin interactor 1 | -0.0294955 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0293945 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289168 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0289151 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0288742 |
| DENND2C | DENN/MADD domain containing 2C | -0.0284786 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0283761 |
| RPL8 | ribosomal protein L8 | -0.0282888 |
| OGA | O-GlcNAcase | -0.0282199 |
| AK1 | adenylate kinase 1 | -0.0280728 |
| RPL27A | ribosomal protein L27a | -0.0278722 |
| MXD1 | MAX dimerization protein 1 | -0.0277978 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0277405 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0276376 |
| PMM2 | phosphomannomutase 2 | -0.0271836 |
| RPS25 | ribosomal protein S25 | -0.0271766 |
| SAV1 | salvador family WW domain containing protein 1 | -0.0268179 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0267462 |
| PLAT | plasminogen activator, tissue | -0.0266676 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0265053 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0262444 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0262301 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0262023 |
| HDLBP | high density lipoprotein binding protein | -0.0261209 |
| HM13 | histocompatibility (minor) 13 | -0.0258253 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0257061 |
| DSG2 | desmoglein 2 | -0.0257052 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0255656 |
