Neratinib (maleate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FBXL20 F-box and leucine-rich repeat protein 20 0.216785
DTNA dystrobrevin, alpha 0.159777
PAWR PRKC, apoptosis, WT1, regulator 0.125575
TRIO trio Rho guanine nucleotide exchange factor 0.108089
LPP LIM domain containing preferred translocation partner in lipoma 0.107811
BCAS3 breast carcinoma amplified sequence 3 0.090229
MYH9 myosin, heavy chain 9, non-muscle 0.0844261
IGF1R insulin-like growth factor 1 receptor 0.0775095
NEBL nebulette 0.0753216
CTNND1 catenin (cadherin-associated protein), delta 1 0.0732786
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0720951
KMT2E lysine (K)-specific methyltransferase 2E 0.0702287
GRB7 growth factor receptor-bound protein 7 0.0686304
MCL1 myeloid cell leukemia 1 0.0679929
NEK7 NIMA-related kinase 7 0.0675506
FNBP1L formin binding protein 1-like 0.0659887
NCOA2 nuclear receptor coactivator 2 0.0629596
CREB5 cAMP responsive element binding protein 5 0.0624404
UBE2H ubiquitin-conjugating enzyme E2H 0.0618961
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0614255
YPEL2 yippee-like 2 (Drosophila) 0.0608103
BCAS1 breast carcinoma amplified sequence 1 0.0608014
MACF1 microtubule-actin crosslinking factor 1 0.060408
CCDC6 coiled-coil domain containing 6 0.059477
VMP1 vacuole membrane protein 1 0.059448
ZNF292 zinc finger protein 292 0.0591985
SAMD4A sterile alpha motif domain containing 4A 0.0578003
NCOA3 nuclear receptor coactivator 3 0.0575962
KLF6 Kruppel-like factor 6 0.0570408
ANKRD11 ankyrin repeat domain 11 0.056692
FOXO3 forkhead box O3 0.0564074
TOM1L1 target of myb1 (chicken)-like 1 0.0556988
JMJD1C jumonji domain containing 1C 0.0555082
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0546171
YAP1 Yes-associated protein 1 0.0542659
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0535585
TUFT1 tuftelin 1 0.0535526
NAMPT nicotinamide phosphoribosyltransferase 0.0534076
AHNAK AHNAK nucleoprotein 0.0528945
JAK1 Janus kinase 1 0.0528458
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0520573
RORA RAR-related orphan receptor A 0.0509143
PUM2 pumilio RNA-binding family member 2 0.0502824
PTK2 protein tyrosine kinase 2 0.0495396
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0495177
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0493093
FOXP1 forkhead box P1 0.0487817
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0485824
WWC1 WW and C2 domain containing 1 0.0483231
EXT1 exostosin glycosyltransferase 1 0.0482228
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0481859
KMT2C lysine (K)-specific methyltransferase 2C 0.0474597
KLHL24 kelch-like family member 24 0.0470478
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0469379
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0466901
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0460423
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0441909
ZFAND3 zinc finger, AN1-type domain 3 0.0441001
TSC22D2 TSC22 domain family, member 2 0.0440949
NUPR1 nuclear protein, transcriptional regulator, 1 0.0438031
TPD52 tumor protein D52 0.0437099
CLIP1 CAP-GLY domain containing linker protein 1 0.043647
AHCTF1 AT hook containing transcription factor 1 0.043476
TMCC1 transmembrane and coiled-coil domain family 1 0.0423649
BRWD1 bromodomain and WD repeat domain containing 1 0.0421015
PDLIM5 PDZ and LIM domain 5 0.0416701
GARS1 glycyl-tRNA synthetase 1 0.0413412
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0407116
SHROOM3 shroom family member 3 0.04067
FOXN3 forkhead box N3 0.0404075
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.040182
MBNL2 muscleblind-like splicing regulator 2 0.0401153
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0399329
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0399053
RBM39 RNA binding motif protein 39 0.039886
CSNK1A1 casein kinase 1, alpha 1 0.0398845
OGA O-GlcNAcase 0.0398619
MED13L mediator complex subunit 13-like 0.0395448
FXR1 fragile X mental retardation, autosomal homolog 1 0.0394779
NIPBL Nipped-B homolog (Drosophila) 0.0393925
COBL cordon-bleu WH2 repeat protein 0.0391091
TRPS1 trichorhinophalangeal syndrome I 0.0390763
SQSTM1 sequestosome 1 0.039013
VGLL4 vestigial-like family member 4 0.0388522
RTN3 reticulon 3 0.0386542
MYO10 myosin X 0.0383395
MYO5B myosin VB 0.0380916
TNRC6A trinucleotide repeat containing 6A 0.0375168
AKAP9 A kinase (PRKA) anchor protein 9 0.0372242
PRRC2B proline-rich coiled-coil 2B 0.0372147
CREBRF CREB3 regulatory factor 0.0370638
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.036786
RUNX1 runt-related transcription factor 1 0.0366623
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0366485
TMEM178B transmembrane protein 178B 0.0365293
PARD3 par-3 family cell polarity regulator 0.0363052
DNAH5 dynein, axonemal, heavy chain 5 0.036279
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0362305
TRA2A transformer 2 alpha homolog (Drosophila) 0.0358779
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0355443

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108795
CATSPERB catsper channel auxiliary subunit beta -0.0872204
RPL19 ribosomal protein L19 -0.0744172
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0713328
FTH1 ferritin, heavy polypeptide 1 -0.0710044
IGFBP5 insulin-like growth factor binding protein 5 -0.0683818
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0658968
ASPH aspartate beta-hydroxylase -0.0634271
RPL23 ribosomal protein L23 -0.0615001
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.06007
TC2N tandem C2 domains, nuclear -0.0451051
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0441097
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.044056
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0436477
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0425894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0414116
EGFR epidermal growth factor receptor -0.0398516
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0389528
OSMR oncostatin M receptor -0.038905
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0383663
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0368003
CCND1 cyclin D1 -0.036719
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0365019
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0362116
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.036113
LDHA lactate dehydrogenase A -0.0342801
LOC102724023 ES1 protein homolog, mitochondrial -0.0327459
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0323862
HLA-B major histocompatibility complex, class I, B -0.031944
ACTG1 actin gamma 1 -0.0312368
RPL35A ribosomal protein L35a -0.0305763
MMP24OS MMP24 opposite strand -0.030176
ANKRD36C ankyrin repeat domain 36C -0.0296933
RRBP1 ribosome binding protein 1 -0.029579
ZMYND8 zinc finger, MYND-type containing 8 -0.0294767
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0292193
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0276157
LMAN1 lectin, mannose-binding, 1 -0.0269305
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.026747
NCOA7 nuclear receptor coactivator 7 -0.0264716
CEMIP cell migration inducing protein, hyaluronan binding -0.0264047
IFI6 interferon, alpha-inducible protein 6 -0.0262661
CLTC clathrin, heavy chain (Hc) -0.0259686
LOC112694756 uncharaterized LOC112694756 -0.0256675
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0252906
FNDC3A fibronectin type III domain containing 3A -0.0251593
ACACA acetyl-CoA carboxylase alpha -0.0242039
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0237734
TTC6 tetratricopeptide repeat domain 6 -0.0237681
TPT1 tumor protein, translationally-controlled 1 -0.0236495
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0229956
B2M beta-2-microglobulin -0.0229653
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0228547
USO1 USO1 vesicle transport factor -0.0227867
TMSB4X thymosin beta 4, X-linked -0.0227622
PDIA3 protein disulfide isomerase family A, member 3 -0.0226572
TMEM45B transmembrane protein 45B -0.0224621
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0217744
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0216591
GMDS GDP-mannose 4,6-dehydratase -0.0215723
CALU calumenin -0.0214673
TMEM165 transmembrane protein 165 -0.0211505
EGR1 early growth response 1 -0.0208538
RPL27A ribosomal protein L27a -0.0207914
TUBA1B tubulin, alpha 1b -0.0207899
RPL12 ribosomal protein L12 -0.0203389
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.020299
BZW1 basic leucine zipper and W2 domains 1 -0.020133
SRCIN1 SRC kinase signaling inhibitor 1 -0.0198317
SEC24A SEC24 family member A -0.0197383
BPTF bromodomain PHD finger transcription factor -0.0197307
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0194952
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0193034
RAI14 retinoic acid induced 14 -0.0191715
ITGB6 integrin, beta 6 -0.0191674
INHBA inhibin, beta A -0.0189849
S100A9 S100 calcium binding protein A9 -0.0185814
S100A14 S100 calcium binding protein A14 -0.0182403
EPAS1 endothelial PAS domain protein 1 -0.0179979
LDLR low density lipoprotein receptor -0.0177312
TMC5 transmembrane channel-like 5 -0.0177307
VDAC1 voltage-dependent anion channel 1 -0.0176954
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.017519
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0173666
FASN fatty acid synthase -0.0173634
PCED1B PC-esterase domain containing 1B -0.0173312
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.017268
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0172466
ESRRG estrogen-related receptor gamma -0.0172357
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.017063
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0170562
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0170489
HLA-C major histocompatibility complex, class I, C -0.0169684
FADS2 fatty acid desaturase 2 -0.0169673
ZCCHC2 zinc finger, CCHC domain containing 2 -0.0169478
RBPMS RNA binding protein with multiple splicing -0.0169117
MIPOL1 mirror-image polydactyly 1 -0.0168695
TNIK TRAF2 and NCK interacting kinase -0.0168178
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0167685
RPL8 ribosomal protein L8 -0.0167444