Neratinib (maleate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) 0.19893
COL5A2 collagen, type V, alpha 2 0.188603
TENM3 teneurin transmembrane protein 3 0.184428
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.180944
ERBB4 erb-b2 receptor tyrosine kinase 4 0.153883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.13364
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.126365
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.113096
CADM2 cell adhesion molecule 2 0.100751
ARHGAP32 Rho GTPase activating protein 32 0.0954715
DST dystonin 0.0933221
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.087772
PCBP2 poly(rC) binding protein 2 0.081663
GARS1 glycyl-tRNA synthetase 1 0.0815007
ANK2 ankyrin 2, neuronal 0.0804588
CDH18 cadherin 18, type 2 0.0765096
MAP1B microtubule-associated protein 1B 0.075723
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0747368
PSAT1 phosphoserine aminotransferase 1 0.0729124
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0727115
AUTS2 autism susceptibility candidate 2 0.0711036
DOCK3 dedicator of cytokinesis 3 0.0677371
IARS1 isoleucyl-tRNA synthetase 1 0.0662078
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0648893
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0642751
ANKRD11 ankyrin repeat domain 11 0.0641764
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0635324
NEBL nebulette 0.0609534
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0564334
TRIO trio Rho guanine nucleotide exchange factor 0.0557255
SHROOM3 shroom family member 3 0.0555815
CELF2 CUGBP, Elav-like family member 2 0.0551991
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0547097
CEP112 centrosomal protein 112kDa 0.0536184
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0529377
SOX5 SRY (sex determining region Y)-box 5 0.0525452
NALF1 NALCN channel auxiliary factor 1 0.0523385
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0521004
AARS1 alanyl-tRNA synthetase 1 0.0500135
TBC1D5 TBC1 domain family, member 5 0.0479185
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0478699
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.045906
WWOX WW domain containing oxidoreductase 0.0458797
GAB2 GRB2-associated binding protein 2 0.0443575
N4BP2L2 NEDD4 binding protein 2-like 2 0.0443315
DCDC2 doublecortin domain containing 2 0.0429797
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0428292
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0421441
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0412845
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0411961
ZFAND3 zinc finger, AN1-type domain 3 0.0405623
XPOT exportin, tRNA 0.040281
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0396582
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0389773
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.0389389
NRG1 neuregulin 1 0.038014
LARS1 leucyl-tRNA synthetase 1 0.0376359
TXNRD1 thioredoxin reductase 1 0.0375945
CUX1 cut-like homeobox 1 0.0375459
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0374923
CLIC4 chloride intracellular channel 4 0.037192
SESN2 sestrin 2 0.0368371
NIBAN1 niban apoptosis regulator 1 0.0368322
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0366522
NCOR1 nuclear receptor corepressor 1 0.036538
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0362225
RPS18 ribosomal protein S18 0.0360189
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0359646
ATF4 activating transcription factor 4 0.0359389
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0354148
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0350504
ADAR adenosine deaminase, RNA-specific 0.0343065
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0342265
NARS1 asparaginyl-tRNA synthetase 1 0.0341978
EEF2 eukaryotic translation elongation factor 2 0.0341858
APP amyloid beta (A4) precursor protein 0.0340339
RANBP17 RAN binding protein 17 0.0336337
TPM4 tropomyosin 4 0.0332861
EXOC6B exocyst complex component 6B 0.0332639
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0331639
POTEF POTE ankyrin domain family, member F 0.0324485
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0323739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0318954
RPL3 ribosomal protein L3 0.0316744
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0313762
MARS1 methionyl-tRNA synthetase 1 0.0313402
ZNF608 zinc finger protein 608 0.0312766
YARS1 tyrosyl-tRNA synthetase 1 0.0311313
ZNF644 zinc finger protein 644 0.0309667
KMT2C lysine (K)-specific methyltransferase 2C 0.0309333
FHIT fragile histidine triad 0.0308193
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0301532
CALD1 caldesmon 1 0.0301203
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0297636
CARS1 cysteinyl-tRNA synthetase 1 0.0296774
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0295676
PRELID2 PRELI domain containing 2 0.0295629
MAP4 microtubule-associated protein 4 0.0292924
FLNA filamin A, alpha 0.0292715
BNC2 basonuclin 2 0.0291939

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112141
PTMA prothymosin, alpha -0.0670336
RPS8 ribosomal protein S8 -0.0578401
RPLP1 ribosomal protein, large, P1 -0.0553578
RPS6 ribosomal protein S6 -0.0506472
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0491343
NPAS3 neuronal PAS domain protein 3 -0.0488865
EGR1 early growth response 1 -0.0486157
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0483046
RPL11 ribosomal protein L11 -0.0479707
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0477683
RPS24 ribosomal protein S24 -0.0456021
RPL34 ribosomal protein L34 -0.0420005
SOX4 SRY (sex determining region Y)-box 4 -0.0415104
MYL12B myosin, light chain 12B, regulatory -0.0413467
TPT1 tumor protein, translationally-controlled 1 -0.039811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393989
ATP11A ATPase, class VI, type 11A -0.0390456
RAD51B RAD51 paralog B -0.038514
RPL28 ribosomal protein L28 -0.037796
RPLP2 ribosomal protein, large, P2 -0.0376849
RPL35A ribosomal protein L35a -0.0372994
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0364585
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0358067
RPL5 ribosomal protein L5 -0.0348984
RPS29 ribosomal protein S29 -0.0342262
RPL9 ribosomal protein L9 -0.0340097
RPS19 ribosomal protein S19 -0.0339214
RPL13A ribosomal protein L13a -0.0335767
RPL32 ribosomal protein L32 -0.0334304
HMGB1 high mobility group box 1 -0.0326295
SLF1 SMC5-SMC6 complex localization factor 1 -0.0320507
RPL26 ribosomal protein L26 -0.0319659
WDR45B WD repeat domain 45B -0.0319373
RPS11 ribosomal protein S11 -0.0315102
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0314922
RPL36 ribosomal protein L36 -0.0314525
RPS16 ribosomal protein S16 -0.0312824
PNISR PNN-interacting serine/arginine-rich protein -0.0311639
TTC3 tetratricopeptide repeat domain 3 -0.0309105
NGLY1 N-glycanase 1 -0.0299637
RPL7A ribosomal protein L7a -0.0299551
RPS21 ribosomal protein S21 -0.0297869
KDM3A lysine (K)-specific demethylase 3A -0.0290999
RPS15 ribosomal protein S15 -0.0281407
RPS27A ribosomal protein S27a -0.0278278
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0264416
RNMT RNA (guanine-7-) methyltransferase -0.0263152
RBM25 RNA binding motif protein 25 -0.0260748
RPL12 ribosomal protein L12 -0.0254555
RPL23 ribosomal protein L23 -0.025065
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0247566
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0242553
RPS5 ribosomal protein S5 -0.0242549
RPL30 ribosomal protein L30 -0.0240245
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0237936
TET2 tet methylcytosine dioxygenase 2 -0.0233995
RPS25 ribosomal protein S25 -0.0233783
VDAC1 voltage-dependent anion channel 1 -0.0231035
RPS28 ribosomal protein S28 -0.022668
RPS23 ribosomal protein S23 -0.0218694
SYAP1 synapse associated protein 1 -0.0216566
HHIP hedgehog interacting protein -0.0211069
PDGFA platelet-derived growth factor alpha polypeptide -0.020867
RPL38 ribosomal protein L38 -0.0207513
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0206103
RAP1B RAP1B, member of RAS oncogene family -0.0205544
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0204605
RPS4X ribosomal protein S4, X-linked -0.0202021
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0200757
WSB1 WD repeat and SOCS box containing 1 -0.0200753
RPL31 ribosomal protein L31 -0.0196027
BRWD3 bromodomain and WD repeat domain containing 3 -0.0193632
RPL8 ribosomal protein L8 -0.0189041
FAM162A family with sequence similarity 162, member A -0.0188174
SNX3 sorting nexin 3 -0.0187617
PHIP pleckstrin homology domain interacting protein -0.0187515
RPL36A ribosomal protein L36a -0.0187265
ATP5F1E ATP synthase F1 subunit epsilon -0.0186315
RPL27A ribosomal protein L27a -0.0185687
ARB2A ARB2 cotranscriptional regulator A -0.0180631
RPL37A ribosomal protein L37a -0.0180075
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0179826
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.017915
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0178748
RPL19 ribosomal protein L19 -0.0178287
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0176603
RAB1A RAB1A, member RAS oncogene family -0.0176196
RPL39 ribosomal protein L39 -0.0173936
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0173438
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.017235
GUK1 guanylate kinase 1 -0.0170762
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0169845
HMGB2 high mobility group box 2 -0.0168243
RPLP0 ribosomal protein, large, P0 -0.0163635
MIDN midnolin -0.0163468
CEP95 centrosomal protein 95kDa -0.0162179
SEPTIN7 septin 7 -0.0160232
RPS13 ribosomal protein S13 -0.0157436
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0157135