| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.252996 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.146449 |
| FN1 | fibronectin 1 | 0.114738 |
| ASPH | aspartate beta-hydroxylase | 0.105742 |
| PRELID2 | PRELI domain containing 2 | 0.0874777 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0819764 |
| LMNA | lamin A/C | 0.0794703 |
| MT2A | metallothionein 2A | 0.0754506 |
| DST | dystonin | 0.0700818 |
| NAV1 | neuron navigator 1 | 0.069252 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0672481 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0667158 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0661346 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.064927 |
| SETBP1 | SET binding protein 1 | 0.0640713 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0630463 |
| EXOC4 | exocyst complex component 4 | 0.0615783 |
| ANK2 | ankyrin 2, neuronal | 0.0604123 |
| PLEC | plectin | 0.0600719 |
| ENO1 | enolase 1, (alpha) | 0.0561671 |
| APP | amyloid beta (A4) precursor protein | 0.0537395 |
| PYGB | phosphorylase, glycogen; brain | 0.0537216 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0534736 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.052894 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0524939 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0513835 |
| FMN1 | formin 1 | 0.0512388 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0497605 |
| LDHA | lactate dehydrogenase A | 0.0489474 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0485434 |
| HMGA1 | high mobility group AT-hook 1 | 0.0481423 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0474054 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0468931 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0465374 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.046446 |
| ACTN1 | actinin, alpha 1 | 0.0459793 |
| AHNAK | AHNAK nucleoprotein | 0.0456014 |
| RAD51B | RAD51 paralog B | 0.0448472 |
| RNF213 | ring finger protein 213 | 0.0445385 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0432516 |
| SEPTIN9 | septin 9 | 0.0429457 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0429227 |
| SMYD3 | SET and MYND domain containing 3 | 0.0425579 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0401564 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.0394387 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0386214 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0380999 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0376318 |
| ANXA2 | annexin A2 | 0.0369565 |
| FMNL2 | formin-like 2 | 0.0364416 |
| S100A6 | S100 calcium binding protein A6 | 0.035746 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0356868 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0355269 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0354705 |
| SFTPA2 | surfactant protein A2 | 0.0348351 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0337451 |
| VIM | vimentin | 0.0336876 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0332151 |
| PCBP2 | poly(rC) binding protein 2 | 0.0331897 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0329718 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0324174 |
| COL19A1 | collagen, type XIX, alpha 1 | 0.0321127 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0319736 |
| MYOF | myoferlin | 0.0318996 |
| MCL1 | myeloid cell leukemia 1 | 0.0314306 |
| UTRN | utrophin | 0.0313359 |
| FLNA | filamin A, alpha | 0.0312682 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | 0.0311346 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0310337 |
| RASA3 | RAS p21 protein activator 3 | 0.0304466 |
| AFDN | afadin, adherens junction formation factor | 0.0301876 |
| ZYX | zyxin | 0.0301479 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0295907 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0291047 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0285982 |
| NBEA | neurobeachin | 0.0282538 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0277061 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0275959 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0275221 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0273589 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0272414 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0271993 |
| ANO6 | anoctamin 6 | 0.0266195 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0265253 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0264546 |
| RPL3 | ribosomal protein L3 | 0.0262525 |
| MAP1B | microtubule-associated protein 1B | 0.0261046 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0258227 |
| ATF4 | activating transcription factor 4 | 0.025626 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0252356 |
| TPM3 | tropomyosin 3 | 0.0247595 |
| RHOB | ras homolog family member B | 0.0247458 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0246156 |
| CD44 | CD44 molecule (Indian blood group) | 0.0245668 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0242847 |
| PLAT | plasminogen activator, tissue | 0.024265 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0242061 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.023922 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0238346 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.023697 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.266053 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.137421 |
| DCT | dopachrome tautomerase | -0.131584 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.125344 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0884205 |
| VGF | VGF nerve growth factor inducible | -0.0870738 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0832619 |
| GPC6 | glypican 6 | -0.0792672 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0730245 |
| CALU | calumenin | -0.0712319 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0696373 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0661066 |
| NLGN1 | neuroligin 1 | -0.0648727 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0600635 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0597637 |
| GDF15 | growth differentiation factor 15 | -0.0569174 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0567153 |
| HLA-B | major histocompatibility complex, class I, B | -0.0566845 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0523705 |
| COPA | coatomer protein complex, subunit alpha | -0.0505118 |
| RUNX1 | runt-related transcription factor 1 | -0.049386 |
| HMCN1 | hemicentin 1 | -0.0485489 |
| WDR45B | WD repeat domain 45B | -0.0482817 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0477085 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0460659 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0459327 |
| GOLGA4 | golgin A4 | -0.0446846 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0441806 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0430389 |
| SCFD2 | sec1 family domain containing 2 | -0.0426939 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0424599 |
| OXR1 | oxidation resistance 1 | -0.0422902 |
| TMEM123 | transmembrane protein 123 | -0.0416112 |
| CDC73 | cell division cycle 73 | -0.0415869 |
| NUP58 | nucleoporin 58 | -0.0415106 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0408534 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.040037 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0394606 |
| ZNF292 | zinc finger protein 292 | -0.0389584 |
| HELZ | helicase with zinc finger | -0.0382284 |
| IER3 | immediate early response 3 | -0.0368812 |
| CENPF | centromere protein F, 350/400kDa | -0.0363114 |
| GHR | growth hormone receptor | -0.0354062 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.0353095 |
| S100A9 | S100 calcium binding protein A9 | -0.0351052 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.034696 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0345117 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0344551 |
| NBAS | neuroblastoma amplified sequence | -0.0339008 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0336014 |
| PTCHD4 | patched domain containing 4 | -0.0333258 |
| SEC24A | SEC24 family member A | -0.033206 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0329153 |
| PDE10A | phosphodiesterase 10A | -0.0329002 |
| PTMA | prothymosin, alpha | -0.0323995 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0316981 |
| RLF | rearranged L-myc fusion | -0.0311847 |
| FRMD4A | FERM domain containing 4A | -0.0308858 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0306651 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0302609 |
| ZC3H7A | zinc finger CCCH-type containing 7A | -0.0302128 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0301391 |
| MTPN | myotrophin | -0.0296816 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0295518 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0288371 |
| CD109 | CD109 molecule | -0.0288163 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0286619 |
| SSH1 | slingshot protein phosphatase 1 | -0.0284602 |
| FOXJ3 | forkhead box J3 | -0.0280384 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0279231 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0279125 |
| TMEM263 | transmembrane protein 263 | -0.0277143 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0276475 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.027619 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0274299 |
| PHF21A | PHD finger protein 21A | -0.0267166 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0266975 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0266533 |
| NRCAM | neuronal cell adhesion molecule | -0.0265999 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0265615 |
| POM121 | POM121 transmembrane nucleoporin | -0.0263939 |
| RHEB | Ras homolog enriched in brain | -0.02631 |
| FUS | FUS RNA binding protein | -0.0260573 |
| LSAMP | limbic system-associated membrane protein | -0.0259759 |
| VDAC1 | voltage-dependent anion channel 1 | -0.025724 |
| CTSD | cathepsin D | -0.0255314 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.024778 |
| RPL35A | ribosomal protein L35a | -0.0247689 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0246508 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0246491 |
| CALR | calreticulin | -0.024242 |
| TFG | TRK-fused gene | -0.0239941 |
| AGMO | alkylglycerol monooxygenase | -0.0238576 |
| RPLP1 | ribosomal protein, large, P1 | -0.0233705 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0230747 |
| NPR2 | natriuretic peptide receptor 2 | -0.0228917 |
| RPS6 | ribosomal protein S6 | -0.0227992 |
| AHR | aryl hydrocarbon receptor | -0.0226619 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0223779 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0220287 |
