| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | 0.144221 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.125174 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.119191 |
| FTL | ferritin, light polypeptide | 0.101837 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.100475 |
| MCL1 | myeloid cell leukemia 1 | 0.0846676 |
| HDAC9 | histone deacetylase 9 | 0.0810292 |
| PCBP2 | poly(rC) binding protein 2 | 0.079399 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0763663 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.075431 |
| MYO5B | myosin VB | 0.0740406 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0706 |
| VEGFA | vascular endothelial growth factor A | 0.0705674 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.065533 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0650335 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0636528 |
| MUC4 | mucin 4, cell surface associated | 0.0616738 |
| CLDN4 | claudin 4 | 0.0606435 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0601386 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0599722 |
| SVIL | supervillin | 0.058547 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0584284 |
| KLF6 | Kruppel-like factor 6 | 0.0581061 |
| UBC | ubiquitin C | 0.0575654 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0574722 |
| DTNA | dystrobrevin, alpha | 0.0569885 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0548592 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0543781 |
| JUP | junction plakoglobin | 0.0542835 |
| B2M | beta-2-microglobulin | 0.0538496 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0538158 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0533525 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0530448 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0519898 |
| TXNRD1 | thioredoxin reductase 1 | 0.0515713 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0514141 |
| STC2 | stanniocalcin 2 | 0.0507861 |
| FMNL2 | formin-like 2 | 0.0507191 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0503966 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0500205 |
| SQSTM1 | sequestosome 1 | 0.0484009 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0481441 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0479029 |
| OPTN | optineurin | 0.046383 |
| DST | dystonin | 0.0443864 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0443749 |
| APOL1 | apolipoprotein L, 1 | 0.043908 |
| RAI14 | retinoic acid induced 14 | 0.0437305 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0427946 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.042213 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0418866 |
| EZR | ezrin | 0.0415053 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0410577 |
| TGM2 | transglutaminase 2 | 0.0403526 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.0401941 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0401448 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0397154 |
| APP | amyloid beta (A4) precursor protein | 0.0396582 |
| DSPP | dentin sialophosphoprotein | 0.0395227 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0393253 |
| RASAL2 | RAS protein activator like 2 | 0.0376916 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0363616 |
| HLA-A | major histocompatibility complex, class I, A | 0.0353988 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0342575 |
| KRT19 | keratin 19, type I | 0.0340143 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0331177 |
| BCL2L1 | BCL2-like 1 | 0.0327031 |
| JUN | jun proto-oncogene | 0.032575 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0325701 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0321997 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0319424 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 0.031927 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0315829 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0311669 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0311409 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0308102 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0307543 |
| TJP1 | tight junction protein 1 | 0.0306839 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0305408 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0305401 |
| TPM3 | tropomyosin 3 | 0.0305159 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0303303 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0300734 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0292998 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0292975 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0292332 |
| RAD51B | RAD51 paralog B | 0.0291769 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0290867 |
| PLEC | plectin | 0.0290122 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0289538 |
| APOL2 | apolipoprotein L, 2 | 0.0285637 |
| CSTB | cystatin B (stefin B) | 0.0281983 |
| RPS18 | ribosomal protein S18 | 0.0281438 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0280731 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0277928 |
| BRD2 | bromodomain containing 2 | 0.027613 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0273402 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0270925 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0269101 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0268806 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MMP7 | matrix metallopeptidase 7 | -0.160131 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.153092 |
| PTMA | prothymosin, alpha | -0.133096 |
| ASPH | aspartate beta-hydroxylase | -0.131846 |
| TMSB10 | thymosin beta 10 | -0.109561 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0998754 |
| LAMA4 | laminin, alpha 4 | -0.0909423 |
| EFNA5 | ephrin-A5 | -0.0882315 |
| TMSB4X | thymosin beta 4, X-linked | -0.0856168 |
| LAMC2 | laminin, gamma 2 | -0.0827898 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0785558 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0782056 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0773046 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0768135 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0737594 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0720055 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0706614 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0630161 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0626092 |
| HLA-B | major histocompatibility complex, class I, B | -0.062315 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0610433 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | -0.0581899 |
| CD2AP | CD2-associated protein | -0.0565941 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0545374 |
| RPS24 | ribosomal protein S24 | -0.0528722 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0527181 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0507053 |
| NCKAP5 | NCK-associated protein 5 | -0.0503272 |
| CDK6 | cyclin-dependent kinase 6 | -0.0498417 |
| ACTG1 | actin gamma 1 | -0.0496633 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0494765 |
| ITGA6 | integrin, alpha 6 | -0.0493476 |
| CP | ceruloplasmin (ferroxidase) | -0.0475053 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0470134 |
| HMGA2 | high mobility group AT-hook 2 | -0.0468996 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0468753 |
| PLAT | plasminogen activator, tissue | -0.046211 |
| RPS21 | ribosomal protein S21 | -0.0458643 |
| VCL | vinculin | -0.0457795 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0451491 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0446897 |
| PGK1 | phosphoglycerate kinase 1 | -0.044528 |
| LAMB3 | laminin, beta 3 | -0.0435585 |
| CD44 | CD44 molecule (Indian blood group) | -0.0425764 |
| EREG | epiregulin | -0.0414168 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0413235 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0409993 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0409234 |
| ITGA1 | integrin, alpha 1 | -0.0407957 |
| PRKCA | protein kinase C, alpha | -0.0407622 |
| NDRG1 | N-myc downstream regulated 1 | -0.0405954 |
| RPL35A | ribosomal protein L35a | -0.0390762 |
| RPL23 | ribosomal protein L23 | -0.0389964 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0387245 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0379183 |
| IER3 | immediate early response 3 | -0.0378246 |
| TPM1 | tropomyosin 1 (alpha) | -0.037651 |
| SP100 | SP100 nuclear antigen | -0.0370055 |
| AHR | aryl hydrocarbon receptor | -0.0367155 |
| ANXA2 | annexin A2 | -0.0366134 |
| RRBP1 | ribosome binding protein 1 | -0.0363028 |
| EHBP1 | EH domain binding protein 1 | -0.0360837 |
| MYOF | myoferlin | -0.0352396 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0351183 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0350434 |
| RPLP1 | ribosomal protein, large, P1 | -0.0348401 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.034805 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0345397 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.034437 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.0344022 |
| KRT8 | keratin 8, type II | -0.0335105 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0330155 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0329803 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0327988 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0327724 |
| RPL34 | ribosomal protein L34 | -0.032507 |
| RPL11 | ribosomal protein L11 | -0.0319409 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0318348 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0317891 |
| MKI67 | marker of proliferation Ki-67 | -0.0314567 |
| OGA | O-GlcNAcase | -0.0313978 |
| SMYD3 | SET and MYND domain containing 3 | -0.0313182 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0311681 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0311139 |
| RPS8 | ribosomal protein S8 | -0.0306454 |
| RPL9 | ribosomal protein L9 | -0.0303368 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0303116 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0300739 |
| SHROOM3 | shroom family member 3 | -0.0300284 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0295991 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0294643 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289828 |
| ACTN4 | actinin, alpha 4 | -0.0288332 |
| RPLP0 | ribosomal protein, large, P0 | -0.028389 |
| DENND4A | DENN/MADD domain containing 4A | -0.0283706 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0275526 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0273135 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0272995 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0272612 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0271521 |
