Neratinib (maleate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.280571
NRG1 neuregulin 1 0.211555
NALF1 NALCN channel auxiliary factor 1 0.140243
CEMIP cell migration inducing protein, hyaluronan binding 0.137709
EXT1 exostosin glycosyltransferase 1 0.116007
PLAT plasminogen activator, tissue 0.115563
PTPRD protein tyrosine phosphatase, receptor type, D 0.107192
LINGO2 leucine rich repeat and Ig domain containing 2 0.0903036
THSD4 thrombospondin, type I, domain containing 4 0.0886022
IGFBP3 insulin-like growth factor binding protein 3 0.0856768
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0762181
ANTXR1 anthrax toxin receptor 1 0.072589
LSAMP limbic system-associated membrane protein 0.0715132
FMN1 formin 1 0.0707309
TRIO trio Rho guanine nucleotide exchange factor 0.0705269
MEF2A myocyte enhancer factor 2A 0.0701097
MACF1 microtubule-actin crosslinking factor 1 0.0670322
PALM2AKAP2 PALM2 and AKAP2 fusion 0.065338
SEPTIN9 septin 9 0.0635463
PTPRE protein tyrosine phosphatase, receptor type, E 0.053263
SMAD3 SMAD family member 3 0.0527655
PRKCA protein kinase C, alpha 0.0525009
SLITRK6 SLIT and NTRK-like family, member 6 0.05209
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0510446
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0509147
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0509047
ZBTB20 zinc finger and BTB domain containing 20 0.0505472
FNDC3B fibronectin type III domain containing 3B 0.049829
RNF213 ring finger protein 213 0.0493271
FLT1 fms-related tyrosine kinase 1 0.0487069
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0485905
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0472985
RAD51B RAD51 paralog B 0.0469804
DNMBP dynamin binding protein 0.0465516
STC1 stanniocalcin 1 0.045437
NPAS2 neuronal PAS domain protein 2 0.044775
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.044598
RPTOR regulatory associated protein of MTOR, complex 1 0.0443796
AHNAK AHNAK nucleoprotein 0.0429122
EPAS1 endothelial PAS domain protein 1 0.0428458
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0420639
MCL1 myeloid cell leukemia 1 0.0417431
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0414835
PCBP2 poly(rC) binding protein 2 0.0412081
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0401234
PACS1 phosphofurin acidic cluster sorting protein 1 0.0400876
TIMP3 TIMP metallopeptidase inhibitor 3 0.038934
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.038316
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0382821
LIMCH1 LIM and calponin homology domains 1 0.0382262
CUX1 cut-like homeobox 1 0.038129
ASPH aspartate beta-hydroxylase 0.0379419
SOS1 son of sevenless homolog 1 (Drosophila) 0.0376539
KLHL13 kelch-like family member 13 0.0376294
EEF2 eukaryotic translation elongation factor 2 0.0376215
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.037577
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0373589
BICD1 bicaudal D homolog 1 (Drosophila) 0.0371653
CRH corticotropin releasing hormone 0.0365444
DIAPH2 diaphanous-related formin 2 0.0352776
MYH9 myosin, heavy chain 9, non-muscle 0.0352729
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0344304
KCTD16 potassium channel tetramerization domain containing 16 0.0341413
COL4A5 collagen, type IV, alpha 5 0.0339626
DST dystonin 0.0331793
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.032712
SETBP1 SET binding protein 1 0.0324139
ITPRID2 ITPR interacting domain containing 2 0.0320704
VCAN versican 0.0319436
MEIS2 Meis homeobox 2 0.0317284
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0311831
PCBP3 poly(rC) binding protein 3 0.0308497
COL4A2 collagen, type IV, alpha 2 0.0308229
VMP1 vacuole membrane protein 1 0.0304683
RAI14 retinoic acid induced 14 0.0304305
INSYN2B inhibitory synaptic factor family member 2B 0.030106
COL3A1 collagen, type III, alpha 1 0.0297207
IGFBP5 insulin-like growth factor binding protein 5 0.0294693
ERRFI1 ERBB receptor feedback inhibitor 1 0.0292299
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0288008
BCAS3 breast carcinoma amplified sequence 3 0.0282573
FRMD4A FERM domain containing 4A 0.0276839
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0276224
NAMPT nicotinamide phosphoribosyltransferase 0.0270979
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0270538
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0269268
APP amyloid beta (A4) precursor protein 0.0267939
DNAH14 dynein, axonemal, heavy chain 14 0.0266036
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0264354
PTEN phosphatase and tensin homolog 0.0262581
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0261147
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0260913
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0260533
AHR aryl hydrocarbon receptor 0.0259611
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.025646
CTSB cathepsin B 0.0255872
TRIB2 tribbles pseudokinase 2 0.0255722
ZNF804A zinc finger protein 804A 0.025232
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0252026
HIP1 huntingtin interacting protein 1 0.0250947

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138963
PTMA prothymosin, alpha -0.0632412
RPLP1 ribosomal protein, large, P1 -0.0555288
RPL35A ribosomal protein L35a -0.0535986
TLE4 transducin-like enhancer of split 4 -0.0528842
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0479253
RPL38 ribosomal protein L38 -0.0456063
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0401493
RPS24 ribosomal protein S24 -0.0392084
OGA O-GlcNAcase -0.0368714
RPL23 ribosomal protein L23 -0.0365278
DSCAM Down syndrome cell adhesion molecule -0.0361447
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0356228
TPT1 tumor protein, translationally-controlled 1 -0.0355976
KDM3A lysine (K)-specific demethylase 3A -0.0352401
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0351103
GOLGA4 golgin A4 -0.0348361
TMSB10 thymosin beta 10 -0.0311833
RPL37A ribosomal protein L37a -0.0307732
IGF2 insulin-like growth factor 2 -0.0307132
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0305061
RPL34 ribosomal protein L34 -0.0295945
HMGB2 high mobility group box 2 -0.0294732
PRRC2C proline-rich coiled-coil 2C -0.0273604
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.027122
RPL12 ribosomal protein L12 -0.0262583
RPL32 ribosomal protein L32 -0.0261279
FTL ferritin, light polypeptide -0.025719
H3-3B H3.3 histone B -0.0255293
TRA2A transformer 2 alpha homolog (Drosophila) -0.0251575
ACBD3 acyl-CoA binding domain containing 3 -0.0250463
NPEPPS aminopeptidase puromycin sensitive -0.0248925
MBD5 methyl-CpG binding domain protein 5 -0.0243845
WSB1 WD repeat and SOCS box containing 1 -0.0242771
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0240962
GPC5 glypican 5 -0.023761
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0232829
RBM39 RNA binding motif protein 39 -0.0232628
RPS6 ribosomal protein S6 -0.0230954
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0229294
RPS19 ribosomal protein S19 -0.0228106
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0223572
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0221392
NCAM2 neural cell adhesion molecule 2 -0.0216501
TENT5A terminal nucleotidyltransferase 5A -0.0215145
RPL7 ribosomal protein L7 -0.0214887
NAP1L1 nucleosome assembly protein 1-like 1 -0.0212649
CCDC47 coiled-coil domain containing 47 -0.0209952
RAB1A RAB1A, member RAS oncogene family -0.0209462
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0209182
RBM25 RNA binding motif protein 25 -0.020917
RPL19 ribosomal protein L19 -0.0208583
PTPRK protein tyrosine phosphatase, receptor type, K -0.0207713
WDR45B WD repeat domain 45B -0.0206902
KIF5B kinesin family member 5B -0.0199608
CENPF centromere protein F, 350/400kDa -0.0198084
RPL27 ribosomal protein L27 -0.0197996
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0197677
SEC24D SEC24 family member D -0.0190988
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0190523
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0185581
GARS1 glycyl-tRNA synthetase 1 -0.0183383
ZFC3H1 zinc finger, C3H1-type containing -0.0182561
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.018216
PHIP pleckstrin homology domain interacting protein -0.0182104
RPS3 ribosomal protein S3 -0.0181846
RPS21 ribosomal protein S21 -0.0181216
RPL28 ribosomal protein L28 -0.0178321
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0176632
BIRC6 baculoviral IAP repeat containing 6 -0.017563
ZC3H15 zinc finger CCCH-type containing 15 -0.0175372
S100A9 S100 calcium binding protein A9 -0.0172526
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0172077
MARCHF6 membrane associated ring-CH-type finger 6 -0.0170379
GCC2 GRIP and coiled-coil domain containing 2 -0.0165368
RPL9 ribosomal protein L9 -0.0165241
LCORL ligand dependent nuclear receptor corepressor-like -0.016384
TBX2 T-box 2 -0.016235
COG5 component of oligomeric golgi complex 5 -0.0161928
MORF4L2 mortality factor 4 like 2 -0.0161512
RPL7A ribosomal protein L7a -0.016094
VDAC1 voltage-dependent anion channel 1 -0.0160767
PRR11 proline rich 11 -0.0160274
SEC31A SEC31 homolog A (S. cerevisiae) -0.015953
GLG1 golgi glycoprotein 1 -0.0158543
TMEM263 transmembrane protein 263 -0.0156642
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0156057
CD36 CD36 molecule (thrombospondin receptor) -0.0155954
SRP54 signal recognition particle 54kDa -0.0155608
PCLO piccolo presynaptic cytomatrix protein -0.0155092
RPS16 ribosomal protein S16 -0.0152857
KIF21A kinesin family member 21A -0.0152416
PUM2 pumilio RNA-binding family member 2 -0.0152376
MBNL2 muscleblind-like splicing regulator 2 -0.0152093
PRPF3 pre-mRNA processing factor 3 -0.0152045
HELZ helicase with zinc finger -0.0151664
PDE4D phosphodiesterase 4D, cAMP-specific -0.0151122
PREPL prolyl endopeptidase-like -0.0150968
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0150633
CFDP1 craniofacial development protein 1 -0.0149717