| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.271889 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.131638 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.125727 |
| LMO7 | LIM domain 7 | 0.120517 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.114728 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.111109 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.11084 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.091249 |
| PKM | pyruvate kinase, muscle | 0.0835292 |
| ABHD2 | abhydrolase domain containing 2 | 0.0814503 |
| SMAD3 | SMAD family member 3 | 0.0812062 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0806165 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0785052 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0773409 |
| NCKAP5 | NCK-associated protein 5 | 0.0772797 |
| TXNRD1 | thioredoxin reductase 1 | 0.0737747 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0727991 |
| STK24 | serine/threonine kinase 24 | 0.0699272 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0678251 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0630485 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0597856 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0597772 |
| RUNX1 | runt-related transcription factor 1 | 0.0589439 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0586492 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0583321 |
| MLPH | melanophilin | 0.0570418 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0564947 |
| ASPH | aspartate beta-hydroxylase | 0.0562954 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0549992 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0539104 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.053809 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0518625 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0516932 |
| B2M | beta-2-microglobulin | 0.0513168 |
| SPATA13 | spermatogenesis associated 13 | 0.0495688 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0495102 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0490071 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0474478 |
| UBC | ubiquitin C | 0.0470944 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0468207 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0464518 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0458201 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0455478 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0452789 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0451474 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0444456 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.043895 |
| EHBP1 | EH domain binding protein 1 | 0.043291 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0429924 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.042969 |
| ATXN1 | ataxin 1 | 0.0425471 |
| MAP7 | microtubule-associated protein 7 | 0.0419837 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0417666 |
| PGK1 | phosphoglycerate kinase 1 | 0.0416766 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0409018 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0404591 |
| CALR | calreticulin | 0.0403934 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0397453 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0394158 |
| YAP1 | Yes-associated protein 1 | 0.039158 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0389443 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0386764 |
| DST | dystonin | 0.038617 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0386024 |
| FNIP1 | folliculin interacting protein 1 | 0.0385836 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0385065 |
| ANKRD11 | ankyrin repeat domain 11 | 0.038095 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0380752 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0379502 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0367713 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0366692 |
| UBL3 | ubiquitin-like 3 | 0.0358141 |
| GOLGB1 | golgin B1 | 0.0356496 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.035612 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0347653 |
| DENND4C | DENN/MADD domain containing 4C | 0.0345283 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0341526 |
| RNF43 | ring finger protein 43 | 0.0336496 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0336325 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0335955 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0334659 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0333696 |
| RBM26 | RNA binding motif protein 26 | 0.0330864 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0330349 |
| LDHA | lactate dehydrogenase A | 0.0328599 |
| AOPEP | aminopeptidase O (putative) | 0.032313 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0320014 |
| CANX | calnexin | 0.0317605 |
| PCED1B | PC-esterase domain containing 1B | 0.0315701 |
| BCL2L1 | BCL2-like 1 | 0.0315537 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0314997 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0312337 |
| RNF149 | ring finger protein 149 | 0.0312012 |
| MYO5B | myosin VB | 0.0305939 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0305568 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0305224 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0300682 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0297743 |
| PTGR1 | prostaglandin reductase 1 | 0.0296849 |
| APP | amyloid beta (A4) precursor protein | 0.0294787 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.11866 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.102858 |
| RIGI | RNA sensor RIG-I | -0.098418 |
| INTS6 | integrator complex subunit 6 | -0.0926475 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0906523 |
| SQSTM1 | sequestosome 1 | -0.0887841 |
| NPSR1 | neuropeptide S receptor 1 | -0.0849397 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0785287 |
| VCL | vinculin | -0.0611185 |
| AREG | amphiregulin | -0.0567214 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0546637 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0545239 |
| PLSCR2 | phospholipid scramblase 2 | -0.0516253 |
| PTMA | prothymosin, alpha | -0.0476606 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0448232 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0424528 |
| SP100 | SP100 nuclear antigen | -0.042411 |
| ATP11A | ATPase, class VI, type 11A | -0.0375268 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0362972 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0358512 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0355743 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0341546 |
| PRKCA | protein kinase C, alpha | -0.0340715 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0336247 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0334922 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.032545 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0323055 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0312875 |
| PLSCR1 | phospholipid scramblase 1 | -0.0301747 |
| XAF1 | XIAP associated factor 1 | -0.0297879 |
| JUN | jun proto-oncogene | -0.0296992 |
| EGR1 | early growth response 1 | -0.0296088 |
| FBXO39 | F-box protein 39 | -0.0290243 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0286408 |
| TFRC | transferrin receptor | -0.0280614 |
| NABP1 | nucleic acid binding protein 1 | -0.0277667 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0277522 |
| CCDC146 | coiled-coil domain containing 146 | -0.0275791 |
| LCN2 | lipocalin 2 | -0.0273648 |
| DIAPH3 | diaphanous-related formin 3 | -0.0271349 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0265535 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0265242 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0264025 |
| MX1 | MX dynamin-like GTPase 1 | -0.026231 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0257814 |
| NDRG1 | N-myc downstream regulated 1 | -0.0255757 |
| EPHB2 | EPH receptor B2 | -0.0250837 |
| HLA-B | major histocompatibility complex, class I, B | -0.0250111 |
| CCNL1 | cyclin L1 | -0.0247192 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0246006 |
| TMSB10 | thymosin beta 10 | -0.0239457 |
| RNF213 | ring finger protein 213 | -0.0239324 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.023671 |
| MX2 | MX dynamin-like GTPase 2 | -0.0235646 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0233589 |
| IER3 | immediate early response 3 | -0.0231142 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.022884 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0227538 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0225408 |
| RPL37A | ribosomal protein L37a | -0.0223431 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0222628 |
| RPS3 | ribosomal protein S3 | -0.0220801 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0219355 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0218803 |
| RRBP1 | ribosome binding protein 1 | -0.0217568 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0216653 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0216432 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0213953 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0211995 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0211776 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0210326 |
| MUC20 | mucin 20, cell surface associated | -0.0209024 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0205331 |
| TNS4 | tensin 4 | -0.0203079 |
| ERBIN | erbb2 interacting protein | -0.0201969 |
| LAP3 | leucine aminopeptidase 3 | -0.0201578 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0199702 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0196837 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0196329 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0195731 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0192583 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0189095 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0188284 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | -0.0187116 |
| MUC13 | mucin 13, cell surface associated | -0.01839 |
| DENND1A | DENN/MADD domain containing 1A | -0.0183233 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0181915 |
| OXSR1 | oxidative stress responsive 1 | -0.0181684 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0179199 |
| EFNB2 | ephrin-B2 | -0.0178479 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0177648 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.0176524 |
| RRM2 | ribonucleotide reductase M2 | -0.0176432 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0175412 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0174389 |
| SDCBP | syndecan binding protein (syntenin) | -0.0172953 |
| VIM | vimentin | -0.0171798 |
| CEP95 | centrosomal protein 95kDa | -0.0171435 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0171177 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0168265 |
