| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib (maleate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.325634 |
| COL6A3 | collagen, type VI, alpha 3 | 0.184182 |
| AHNAK | AHNAK nucleoprotein | 0.0889499 |
| VEGFA | vascular endothelial growth factor A | 0.075446 |
| PLEC | plectin | 0.0748533 |
| LOXL2 | lysyl oxidase-like 2 | 0.0606082 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0601819 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0584075 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0531644 |
| NDRG1 | N-myc downstream regulated 1 | 0.0522247 |
| APP | amyloid beta (A4) precursor protein | 0.0498282 |
| HDAC9 | histone deacetylase 9 | 0.0468649 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0467341 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0455041 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0408725 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0407509 |
| PCBP2 | poly(rC) binding protein 2 | 0.0401261 |
| COL5A1 | collagen, type V, alpha 1 | 0.0400802 |
| ASPH | aspartate beta-hydroxylase | 0.0385007 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | 0.0364509 |
| ANK2 | ankyrin 2, neuronal | 0.0363026 |
| SMAD3 | SMAD family member 3 | 0.035604 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0339732 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0311347 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0305967 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0303831 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0298965 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0295477 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.029433 |
| CCPG1 | cell cycle progression 1 | 0.0293183 |
| STC1 | stanniocalcin 1 | 0.0292676 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0291448 |
| AUTS2 | autism susceptibility candidate 2 | 0.0289506 |
| ITGA6 | integrin, alpha 6 | 0.0283207 |
| CANX | calnexin | 0.0281431 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0279732 |
| HLA-A | major histocompatibility complex, class I, A | 0.0276631 |
| ZNF638 | zinc finger protein 638 | 0.0274726 |
| DTNA | dystrobrevin, alpha | 0.0270273 |
| FAM219A | family with sequence similarity 219, member A | 0.026067 |
| SQSTM1 | sequestosome 1 | 0.0259772 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0256314 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0252625 |
| EGFR | epidermal growth factor receptor | 0.024183 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.023821 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0237632 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.023721 |
| WWOX | WW domain containing oxidoreductase | 0.0235879 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0234554 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0228644 |
| PAPPA2 | pappalysin 2 | 0.0225323 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0225166 |
| SEPTIN9 | septin 9 | 0.0224906 |
| EXOC4 | exocyst complex component 4 | 0.0224304 |
| FMNL2 | formin-like 2 | 0.0220007 |
| FLNB | filamin B, beta | 0.0219201 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0218265 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0216886 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0214984 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0212963 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0212335 |
| MYLK | myosin light chain kinase | 0.0211743 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0211109 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0210245 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0207052 |
| TPM3 | tropomyosin 3 | 0.0203262 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.0202374 |
| RUNX1 | runt-related transcription factor 1 | 0.0202346 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0201913 |
| STXBP1 | syntaxin binding protein 1 | 0.0192609 |
| FAM13A | family with sequence similarity 13, member A | 0.0192452 |
| FGF13 | fibroblast growth factor 13 | 0.0191843 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0190472 |
| ADCY7 | adenylate cyclase 7 | 0.0189676 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0187988 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0187277 |
| UPP1 | uridine phosphorylase 1 | 0.0185102 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0183535 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0182514 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0181137 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0181081 |
| NAV3 | neuron navigator 3 | 0.018065 |
| SLFN5 | schlafen family member 5 | 0.0179292 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0178424 |
| RNF213 | ring finger protein 213 | 0.0176155 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0175763 |
| CALN1 | calneuron 1 | 0.0175275 |
| ZNF160 | zinc finger protein 160 | 0.0173997 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.01738 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0173155 |
| ZNF395 | zinc finger protein 395 | 0.0172654 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0172625 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.016957 |
| ABR | active BCR-related | 0.0169076 |
| YEATS2 | YEATS domain containing 2 | 0.0168643 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0168348 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0167717 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.0166449 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0165667 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0165646 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.278149 |
| TMSB10 | thymosin beta 10 | -0.116693 |
| FN1 | fibronectin 1 | -0.111977 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.103667 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0774852 |
| FTL | ferritin, light polypeptide | -0.0758512 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0753107 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0695179 |
| LOX | lysyl oxidase | -0.0691161 |
| VCL | vinculin | -0.0523723 |
| VIM | vimentin | -0.0515578 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0513956 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.050262 |
| KYNU | kynureninase | -0.0490944 |
| SBF2 | SET binding factor 2 | -0.0469395 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0464502 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0450929 |
| CALD1 | caldesmon 1 | -0.0450903 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0448588 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0418628 |
| RPL35A | ribosomal protein L35a | -0.0392417 |
| PTMA | prothymosin, alpha | -0.0383812 |
| INHBA | inhibin, beta A | -0.0383641 |
| RPS8 | ribosomal protein S8 | -0.0371139 |
| MT2A | metallothionein 2A | -0.0366773 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0362724 |
| RPS19 | ribosomal protein S19 | -0.0362447 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0351635 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0350184 |
| TPI1 | triosephosphate isomerase 1 | -0.034141 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0335959 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0333417 |
| CD44 | CD44 molecule (Indian blood group) | -0.0328052 |
| RPL12 | ribosomal protein L12 | -0.0326285 |
| RPL11 | ribosomal protein L11 | -0.0315098 |
| TUBB | tubulin, beta class I | -0.0308613 |
| CLTC | clathrin, heavy chain (Hc) | -0.030664 |
| RTN4 | reticulon 4 | -0.0300668 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.030039 |
| B2M | beta-2-microglobulin | -0.0300018 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0298403 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0292503 |
| GOLGA4 | golgin A4 | -0.0291068 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0288175 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.028774 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0286264 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0284705 |
| RPL19 | ribosomal protein L19 | -0.0284602 |
| NABP1 | nucleic acid binding protein 1 | -0.0283591 |
| DST | dystonin | -0.0272651 |
| POTEF | POTE ankyrin domain family, member F | -0.0267957 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0267718 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0267321 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0265645 |
| RPL9 | ribosomal protein L9 | -0.0265325 |
| TUBA1B | tubulin, alpha 1b | -0.0265055 |
| RPLP2 | ribosomal protein, large, P2 | -0.0262053 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0250287 |
| SMC4 | structural maintenance of chromosomes 4 | -0.024898 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0247121 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0244974 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0243538 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0242715 |
| HDLBP | high density lipoprotein binding protein | -0.024159 |
| CCDC102B | coiled-coil domain containing 102B | -0.024052 |
| ACTG1 | actin gamma 1 | -0.02403 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0239997 |
| MT1X | metallothionein 1X | -0.0238804 |
| RPS6 | ribosomal protein S6 | -0.0229625 |
| RPS3 | ribosomal protein S3 | -0.0228229 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0226753 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.0225583 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0225198 |
| RPS21 | ribosomal protein S21 | -0.0225001 |
| RPS11 | ribosomal protein S11 | -0.0222398 |
| CENPF | centromere protein F, 350/400kDa | -0.0221745 |
| SETD5 | SET domain containing 5 | -0.0220211 |
| COG5 | component of oligomeric golgi complex 5 | -0.0220031 |
| STK17A | serine/threonine kinase 17a | -0.0219436 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0218943 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0218856 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0218194 |
| RPS24 | ribosomal protein S24 | -0.021768 |
| RPS27A | ribosomal protein S27a | -0.0217137 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0216811 |
| RPL34 | ribosomal protein L34 | -0.0213533 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -0.0211715 |
| ANLN | anillin, actin binding protein | -0.0209485 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0208129 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0207814 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0207674 |
| TMEM263 | transmembrane protein 263 | -0.020686 |
| MORF4L2 | mortality factor 4 like 2 | -0.0206412 |
| PMM2 | phosphomannomutase 2 | -0.0205959 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0205928 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0201964 |
| PRSS23 | protease, serine, 23 | -0.0201057 |
| RNF216 | ring finger protein 216 | -0.0200483 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0200398 |
| RPL37A | ribosomal protein L37a | -0.0200269 |
