| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.211965 |
| AHNAK | AHNAK nucleoprotein | 0.135052 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.131649 |
| PCBP2 | poly(rC) binding protein 2 | 0.122878 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.101415 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0986755 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0860103 |
| ENO1 | enolase 1, (alpha) | 0.084237 |
| EZR | ezrin | 0.0762003 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0761359 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0639181 |
| FTL | ferritin, light polypeptide | 0.0622493 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0616612 |
| LDHA | lactate dehydrogenase A | 0.0574298 |
| PLEC | plectin | 0.0518814 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0507734 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0491093 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0489098 |
| PGK1 | phosphoglycerate kinase 1 | 0.0469337 |
| KLF6 | Kruppel-like factor 6 | 0.0454867 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0443114 |
| CTBP2 | C-terminal binding protein 2 | 0.0437488 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.041983 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0410268 |
| RIOK3 | RIO kinase 3 | 0.0405013 |
| HELZ | helicase with zinc finger | 0.0390501 |
| VEGFA | vascular endothelial growth factor A | 0.0389258 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0384247 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0379319 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0358618 |
| BRD2 | bromodomain containing 2 | 0.0358498 |
| TXNIP | thioredoxin interacting protein | 0.0350413 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0348781 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0348075 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0334976 |
| RPS18 | ribosomal protein S18 | 0.0333898 |
| RNF24 | ring finger protein 24 | 0.0330752 |
| SNX9 | sorting nexin 9 | 0.032805 |
| ATF4 | activating transcription factor 4 | 0.0326093 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0325968 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0325963 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0322923 |
| MATR3 | matrin 3 | 0.0319986 |
| RPL3 | ribosomal protein L3 | 0.0318529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0311282 |
| SEPTIN9 | septin 9 | 0.0306915 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0304149 |
| DIAPH1 | diaphanous-related formin 1 | 0.0302968 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0299236 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.029265 |
| FOXO3 | forkhead box O3 | 0.0283195 |
| CANX | calnexin | 0.027883 |
| TXNRD1 | thioredoxin reductase 1 | 0.0269643 |
| KRT19 | keratin 19, type I | 0.0268398 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.026647 |
| AEBP2 | AE binding protein 2 | 0.0266303 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0266218 |
| DSPP | dentin sialophosphoprotein | 0.0263266 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0257438 |
| RHOA | ras homolog family member A | 0.0257281 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0256721 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0253311 |
| RNF213 | ring finger protein 213 | 0.0251663 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0251479 |
| PFKP | phosphofructokinase, platelet | 0.0251045 |
| NDRG1 | N-myc downstream regulated 1 | 0.0250537 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0248482 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.024831 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0245181 |
| PARD3 | par-3 family cell polarity regulator | 0.0245054 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0243706 |
| SETD5 | SET domain containing 5 | 0.0242418 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0240092 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0240025 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0236503 |
| CDK19 | cyclin-dependent kinase 19 | 0.0234566 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0234385 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0231451 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0229964 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0228261 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0226877 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0223825 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0220117 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0219942 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0219052 |
| WDR45B | WD repeat domain 45B | 0.0218932 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0217 |
| UBC | ubiquitin C | 0.0214856 |
| NUP58 | nucleoporin 58 | 0.0214048 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0211728 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0211441 |
| B2M | beta-2-microglobulin | 0.0208868 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0208229 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0206757 |
| SFTPA2 | surfactant protein A2 | 0.020508 |
| PKM | pyruvate kinase, muscle | 0.0204872 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0203063 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0202562 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0201428 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0200923 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.202868 |
| FAT1 | FAT atypical cadherin 1 | -0.200472 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.116159 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.102862 |
| TMSB10 | thymosin beta 10 | -0.0845222 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0658435 |
| MKI67 | marker of proliferation Ki-67 | -0.0625787 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0609484 |
| RAD51B | RAD51 paralog B | -0.0607148 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0575664 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0500889 |
| ARF4 | ADP-ribosylation factor 4 | -0.0478237 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0456425 |
| RPS24 | ribosomal protein S24 | -0.0453231 |
| SERINC5 | serine incorporator 5 | -0.0436968 |
| RPL35A | ribosomal protein L35a | -0.0425277 |
| CENPF | centromere protein F, 350/400kDa | -0.0396719 |
| WWOX | WW domain containing oxidoreductase | -0.0368166 |
| INTS6 | integrator complex subunit 6 | -0.0358143 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0357441 |
| DIAPH3 | diaphanous-related formin 3 | -0.0357352 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0351771 |
| HMGA2 | high mobility group AT-hook 2 | -0.0351593 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0337437 |
| RRM2 | ribonucleotide reductase M2 | -0.0336692 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0329102 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0328086 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0326717 |
| SMYD3 | SET and MYND domain containing 3 | -0.0318331 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0315783 |
| HMGB1 | high mobility group box 1 | -0.0305179 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0302772 |
| RPLP2 | ribosomal protein, large, P2 | -0.0302608 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0297543 |
| FRMD5 | FERM domain containing 5 | -0.0291995 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0291002 |
| MSI2 | musashi RNA-binding protein 2 | -0.0289802 |
| VCL | vinculin | -0.0288479 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0288242 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0284796 |
| TMEM263 | transmembrane protein 263 | -0.0282026 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0277766 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0277355 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0275428 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0274981 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0271687 |
| CALU | calumenin | -0.0271282 |
| EREG | epiregulin | -0.0268014 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0265806 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0265239 |
| TBC1D4 | TBC1 domain family, member 4 | -0.0261739 |
| RBBP6 | retinoblastoma binding protein 6 | -0.025638 |
| RPS27A | ribosomal protein S27a | -0.0256339 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0256179 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0253519 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0252926 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0252348 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0246732 |
| HMGB2 | high mobility group box 2 | -0.0246018 |
| RPS21 | ribosomal protein S21 | -0.0243164 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0242962 |
| SEC24D | SEC24 family member D | -0.02427 |
| FUS | FUS RNA binding protein | -0.0237296 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.023538 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.023162 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0230984 |
| RPL12 | ribosomal protein L12 | -0.0230139 |
| ANLN | anillin, actin binding protein | -0.0229334 |
| RRBP1 | ribosome binding protein 1 | -0.0229255 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0227181 |
| TENM3 | teneurin transmembrane protein 3 | -0.0226999 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0221892 |
| HM13 | histocompatibility (minor) 13 | -0.0221412 |
| RPL34 | ribosomal protein L34 | -0.0220219 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.021778 |
| HELLS | helicase, lymphoid-specific | -0.0217119 |
| RPS23 | ribosomal protein S23 | -0.0214134 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0213936 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0213644 |
| NF1 | neurofibromin 1 | -0.0211267 |
| SATB2 | SATB homeobox 2 | -0.0211035 |
| OSBP | oxysterol binding protein | -0.0210669 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0209043 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.020687 |
| CADPS | Ca++-dependent secretion activator | -0.0206234 |
| RNF43 | ring finger protein 43 | -0.020531 |
| SRP72 | signal recognition particle 72kDa | -0.0205243 |
| TCERG1 | transcription elongation regulator 1 | -0.0204864 |
| TUBB | tubulin, beta class I | -0.0204662 |
| MT2A | metallothionein 2A | -0.0204471 |
| CD2AP | CD2-associated protein | -0.0204239 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0201949 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0201938 |
| ECT2 | epithelial cell transforming 2 | -0.0201816 |
| KIAA1958 | KIAA1958 | -0.0200437 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0199902 |
| RPL26 | ribosomal protein L26 | -0.0198788 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0198259 |
| TUBA1B | tubulin, alpha 1b | -0.0196893 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0196444 |
