| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.173254 |
| APP | amyloid beta (A4) precursor protein | 0.14827 |
| PCBP2 | poly(rC) binding protein 2 | 0.109532 |
| TXNRD1 | thioredoxin reductase 1 | 0.101305 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0831545 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0811343 |
| MACROD2 | MACRO domain containing 2 | 0.0779128 |
| FLNA | filamin A, alpha | 0.077799 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0743446 |
| PKM | pyruvate kinase, muscle | 0.0692433 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0666488 |
| EZR | ezrin | 0.0602217 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0601406 |
| RPL3 | ribosomal protein L3 | 0.0571549 |
| POTEF | POTE ankyrin domain family, member F | 0.0570857 |
| STC2 | stanniocalcin 2 | 0.0565801 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.055835 |
| PRELID2 | PRELI domain containing 2 | 0.0557905 |
| TPM3 | tropomyosin 3 | 0.055691 |
| FHIT | fragile histidine triad | 0.0554384 |
| WWOX | WW domain containing oxidoreductase | 0.0550795 |
| SET | SET nuclear proto-oncogene | 0.0546121 |
| ASPH | aspartate beta-hydroxylase | 0.0538144 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0536883 |
| PLEC | plectin | 0.0532374 |
| RAD51B | RAD51 paralog B | 0.052232 |
| DIAPH1 | diaphanous-related formin 1 | 0.0505737 |
| ENO1 | enolase 1, (alpha) | 0.0486853 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0484423 |
| KRT7 | keratin 7, type II | 0.0454875 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0431457 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0428236 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0409729 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0408234 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0396421 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0396083 |
| MYEOV | myeloma overexpressed | 0.0391316 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0385849 |
| SEPTIN9 | septin 9 | 0.0384402 |
| YBX1 | Y box binding protein 1 | 0.0384292 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0382897 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0373797 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0372896 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0368331 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0366707 |
| SETD5 | SET domain containing 5 | 0.0365307 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.036412 |
| ANK2 | ankyrin 2, neuronal | 0.0361105 |
| RPS18 | ribosomal protein S18 | 0.0360718 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0360436 |
| DIAPH3 | diaphanous-related formin 3 | 0.0355671 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0354809 |
| ZNF148 | zinc finger protein 148 | 0.0353745 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0353293 |
| UPP1 | uridine phosphorylase 1 | 0.0350567 |
| AXL | AXL receptor tyrosine kinase | 0.0347342 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0345888 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0342267 |
| CLDN4 | claudin 4 | 0.0341659 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0340719 |
| SUMF1 | sulfatase modifying factor 1 | 0.0340314 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0339861 |
| PRRC2B | proline-rich coiled-coil 2B | 0.033868 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0336089 |
| VEGFA | vascular endothelial growth factor A | 0.0335422 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0333652 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.033077 |
| LDHA | lactate dehydrogenase A | 0.0329684 |
| PTEN | phosphatase and tensin homolog | 0.0322594 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0322189 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0321471 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0321234 |
| FLNB | filamin B, beta | 0.0316459 |
| XPOT | exportin, tRNA | 0.0308892 |
| NFIB | nuclear factor I/B | 0.0307792 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0307487 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0307294 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0305935 |
| DNM2 | dynamin 2 | 0.0304794 |
| FTL | ferritin, light polypeptide | 0.0302791 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.030252 |
| ZNF644 | zinc finger protein 644 | 0.0300612 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0299877 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0299774 |
| TPI1 | triosephosphate isomerase 1 | 0.0299343 |
| CBX5 | chromobox homolog 5 | 0.0292742 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0287373 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0287012 |
| CCND1 | cyclin D1 | 0.0285937 |
| PDGFC | platelet derived growth factor C | 0.0285677 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0284496 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0281782 |
| TUSC3 | tumor suppressor candidate 3 | 0.0281121 |
| SLTM | SAFB-like, transcription modulator | 0.028017 |
| ANXA3 | annexin A3 | 0.027702 |
| UBC | ubiquitin C | 0.0273742 |
| VCAN | versican | 0.0273281 |
| VMP1 | vacuole membrane protein 1 | 0.0272182 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0271434 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0265864 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.161395 |
| TMSB10 | thymosin beta 10 | -0.149516 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.132106 |
| ACTG1 | actin gamma 1 | -0.117433 |
| CD44 | CD44 molecule (Indian blood group) | -0.111223 |
| HMGA2 | high mobility group AT-hook 2 | -0.0997962 |
| LAMB3 | laminin, beta 3 | -0.0894959 |
| LAMC2 | laminin, gamma 2 | -0.086236 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0849981 |
| MT2A | metallothionein 2A | -0.082908 |
| RPL35A | ribosomal protein L35a | -0.0749869 |
| LAMA4 | laminin, alpha 4 | -0.0728413 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0662567 |
| PTMA | prothymosin, alpha | -0.0655594 |
| RPS24 | ribosomal protein S24 | -0.0595768 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0569989 |
| RPL34 | ribosomal protein L34 | -0.048909 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0470288 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0463021 |
| VDAC1 | voltage-dependent anion channel 1 | -0.043949 |
| ANXA2 | annexin A2 | -0.0433084 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0428845 |
| NDRG1 | N-myc downstream regulated 1 | -0.0428798 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0416906 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.040444 |
| RPS8 | ribosomal protein S8 | -0.0403599 |
| S100A10 | S100 calcium binding protein A10 | -0.0403406 |
| EMP1 | epithelial membrane protein 1 | -0.0400106 |
| RPS27A | ribosomal protein S27a | -0.0387034 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0380598 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0372486 |
| RPL32 | ribosomal protein L32 | -0.0366609 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0366254 |
| HMGA1 | high mobility group AT-hook 1 | -0.0363198 |
| RPL9 | ribosomal protein L9 | -0.035471 |
| HMGB1 | high mobility group box 1 | -0.0348585 |
| IER3 | immediate early response 3 | -0.0343039 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0342964 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0336721 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0334058 |
| RPL31 | ribosomal protein L31 | -0.033102 |
| FUS | FUS RNA binding protein | -0.0320412 |
| ITGA6 | integrin, alpha 6 | -0.0316126 |
| CD2AP | CD2-associated protein | -0.031282 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.031216 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0311628 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0303795 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0292698 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0288647 |
| RPL23 | ribosomal protein L23 | -0.0288373 |
| RPLP2 | ribosomal protein, large, P2 | -0.0287156 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0285921 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0285556 |
| SDC4 | syndecan 4 | -0.0284725 |
| CCDC138 | coiled-coil domain containing 138 | -0.0284069 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0283706 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.028271 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0282705 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.028266 |
| ABR | active BCR-related | -0.0281631 |
| SVIL | supervillin | -0.0279897 |
| RPL12 | ribosomal protein L12 | -0.0279783 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0276718 |
| RPLP1 | ribosomal protein, large, P1 | -0.0276663 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0274407 |
| RPL7A | ribosomal protein L7a | -0.0273607 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0271237 |
| RPS6 | ribosomal protein S6 | -0.0269605 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0266494 |
| RPL38 | ribosomal protein L38 | -0.026427 |
| THOC2 | THO complex 2 | -0.0260694 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0257957 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0257877 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0256858 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0254617 |
| TMSB4X | thymosin beta 4, X-linked | -0.0254559 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0253928 |
| SEC24D | SEC24 family member D | -0.0247652 |
| RASA3 | RAS p21 protein activator 3 | -0.0247446 |
| LMO7 | LIM domain 7 | -0.0245537 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.024118 |
| RPL37A | ribosomal protein L37a | -0.0239367 |
| CDK6 | cyclin-dependent kinase 6 | -0.0238281 |
| S100A4 | S100 calcium binding protein A4 | -0.023723 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0233079 |
| ATG7 | autophagy related 7 | -0.023037 |
| WDR45B | WD repeat domain 45B | -0.0228507 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.022708 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0226299 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0222863 |
| RPS11 | ribosomal protein S11 | -0.0221874 |
| SEPTIN7 | septin 7 | -0.0221161 |
| RPS19 | ribosomal protein S19 | -0.0219265 |
| PLAU | plasminogen activator, urokinase | -0.0219099 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0219064 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0218497 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0218176 |
| RPL26 | ribosomal protein L26 | -0.0216538 |
| RPS21 | ribosomal protein S21 | -0.0216348 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0216215 |
