| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.156968 |
| PLEC | plectin | 0.113545 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.100106 |
| MT2A | metallothionein 2A | 0.0870967 |
| SEPTIN9 | septin 9 | 0.0764811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0731441 |
| PCBP2 | poly(rC) binding protein 2 | 0.068212 |
| MSN | moesin | 0.0659968 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0640932 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0639312 |
| COL5A1 | collagen, type V, alpha 1 | 0.0610928 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0609405 |
| AHNAK | AHNAK nucleoprotein | 0.0590847 |
| MAP1B | microtubule-associated protein 1B | 0.0590479 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0555396 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0546976 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0509454 |
| TPM3 | tropomyosin 3 | 0.0498231 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0497069 |
| MCL1 | myeloid cell leukemia 1 | 0.0494573 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0484932 |
| VEGFA | vascular endothelial growth factor A | 0.0482614 |
| LOXL2 | lysyl oxidase-like 2 | 0.0458209 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0450756 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0429879 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0405803 |
| WWOX | WW domain containing oxidoreductase | 0.0405723 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0387165 |
| RPS18 | ribosomal protein S18 | 0.0381172 |
| ENO1 | enolase 1, (alpha) | 0.0372772 |
| RPL3 | ribosomal protein L3 | 0.037078 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0352804 |
| AXL | AXL receptor tyrosine kinase | 0.0343542 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0337492 |
| FLNB | filamin B, beta | 0.0329838 |
| RPS12 | ribosomal protein S12 | 0.0328531 |
| FLNA | filamin A, alpha | 0.0327287 |
| PRELID2 | PRELI domain containing 2 | 0.0326699 |
| NAV1 | neuron navigator 1 | 0.0324427 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0320599 |
| CAPRIN2 | caprin family member 2 | 0.0319699 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0318709 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0312116 |
| ACTN1 | actinin, alpha 1 | 0.0309997 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0308607 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0307194 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.029486 |
| HMGA1 | high mobility group AT-hook 1 | 0.0287371 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.028608 |
| RAD51B | RAD51 paralog B | 0.0284662 |
| EZR | ezrin | 0.0282228 |
| MLPH | melanophilin | 0.0280582 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0278206 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0276517 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0276231 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0274846 |
| DST | dystonin | 0.0273992 |
| EFNA5 | ephrin-A5 | 0.0267901 |
| RPS6 | ribosomal protein S6 | 0.0266313 |
| PODXL | podocalyxin-like | 0.026296 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0260712 |
| TNS1 | tensin 1 | 0.0258831 |
| APP | amyloid beta (A4) precursor protein | 0.0255329 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0255227 |
| PKM | pyruvate kinase, muscle | 0.0252398 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0249867 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0242276 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0241437 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0239962 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0235524 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0235212 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0228934 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0227366 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.022664 |
| EGFR | epidermal growth factor receptor | 0.0226214 |
| FHIT | fragile histidine triad | 0.0218635 |
| RPS3 | ribosomal protein S3 | 0.0217856 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0214076 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0213573 |
| ATF4 | activating transcription factor 4 | 0.021266 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0212518 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0211362 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0206065 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0205172 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0204987 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0204882 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.020364 |
| RPS17 | ribosomal protein S17 | 0.0203299 |
| CLIC4 | chloride intracellular channel 4 | 0.0203047 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0201563 |
| DSPP | dentin sialophosphoprotein | 0.020032 |
| MYADM | myeloid-associated differentiation marker | 0.0197763 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0194402 |
| SMAD3 | SMAD family member 3 | 0.0191458 |
| PFKP | phosphofructokinase, platelet | 0.0191329 |
| RCOR1 | REST corepressor 1 | 0.0190845 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0190242 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0188135 |
| LAMB3 | laminin, beta 3 | 0.0187533 |
| NDRG1 | N-myc downstream regulated 1 | 0.01872 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.45184 |
| FN1 | fibronectin 1 | -0.271224 |
| VIM | vimentin | -0.142171 |
| IGF2 | insulin-like growth factor 2 | -0.136629 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0916385 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0858245 |
| STC1 | stanniocalcin 1 | -0.0838806 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0812254 |
| PTMA | prothymosin, alpha | -0.0804299 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.071787 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0647744 |
| HMGA2 | high mobility group AT-hook 2 | -0.0631851 |
| TENM2 | teneurin transmembrane protein 2 | -0.0622779 |
| LOX | lysyl oxidase | -0.061088 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0608544 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0564643 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0513691 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0510618 |
| ACTG1 | actin gamma 1 | -0.0500948 |
| FAM13A | family with sequence similarity 13, member A | -0.0483852 |
| IER3 | immediate early response 3 | -0.0469881 |
| PDE10A | phosphodiesterase 10A | -0.045919 |
| COL1A1 | collagen, type I, alpha 1 | -0.0458623 |
| RRBP1 | ribosome binding protein 1 | -0.0454052 |
| NGLY1 | N-glycanase 1 | -0.043586 |
| INHBA | inhibin, beta A | -0.0435271 |
| GLIS3 | GLIS family zinc finger 3 | -0.0432528 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0407124 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0403629 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0402456 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0386816 |
| ASPH | aspartate beta-hydroxylase | -0.0384727 |
| TNNC1 | troponin C type 1 (slow) | -0.0383377 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0379864 |
| WDR45B | WD repeat domain 45B | -0.0373033 |
| MORF4L2 | mortality factor 4 like 2 | -0.0359291 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.034773 |
| NF1 | neurofibromin 1 | -0.0347609 |
| OGA | O-GlcNAcase | -0.0338676 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0333582 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.032994 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0329117 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0323736 |
| ZNF292 | zinc finger protein 292 | -0.0321521 |
| HDLBP | high density lipoprotein binding protein | -0.0316503 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0315767 |
| CALU | calumenin | -0.0314525 |
| SEC24A | SEC24 family member A | -0.03134 |
| RLF | rearranged L-myc fusion | -0.0302957 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.030276 |
| PGK1 | phosphoglycerate kinase 1 | -0.0300499 |
| SPAG9 | sperm associated antigen 9 | -0.0297858 |
| SEC24D | SEC24 family member D | -0.0297098 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0294477 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0292532 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0291528 |
| CAVIN1 | caveolae associated protein 1 | -0.0289307 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0287039 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0286468 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0274551 |
| GOLGA4 | golgin A4 | -0.0270443 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0270345 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0268649 |
| TMEM263 | transmembrane protein 263 | -0.026621 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0265605 |
| CDCP1 | CUB domain containing protein 1 | -0.0265388 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0264738 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.026038 |
| HELZ | helicase with zinc finger | -0.0252054 |
| ARF1 | ADP-ribosylation factor 1 | -0.0250867 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0249679 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0249517 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0247926 |
| USP3 | ubiquitin specific peptidase 3 | -0.0247833 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0247188 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0245247 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0244148 |
| ANLN | anillin, actin binding protein | -0.0242174 |
| GNAS | GNAS complex locus | -0.0241398 |
| ETV6 | ets variant 6 | -0.0239559 |
| SBF2 | SET binding factor 2 | -0.0238988 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0238367 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0236039 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0234772 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0234157 |
| ANTXR2 | anthrax toxin receptor 2 | -0.023068 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0227147 |
| THBS1 | thrombospondin 1 | -0.0226778 |
| TMEM165 | transmembrane protein 165 | -0.0225889 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0224822 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0223469 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0221473 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0221204 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0219854 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0219365 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.021565 |
| PRR11 | proline rich 11 | -0.0213403 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0211973 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.021081 |
| FSTL1 | follistatin-like 1 | -0.0209645 |
