| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.180338 |
| COL6A3 | collagen, type VI, alpha 3 | 0.175086 |
| LOXL2 | lysyl oxidase-like 2 | 0.144661 |
| CDH13 | cadherin 13 | 0.120581 |
| VEGFA | vascular endothelial growth factor A | 0.103843 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0962688 |
| PLEC | plectin | 0.0752368 |
| ASPH | aspartate beta-hydroxylase | 0.0702197 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0660521 |
| APP | amyloid beta (A4) precursor protein | 0.0616482 |
| ENO1 | enolase 1, (alpha) | 0.0585656 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0583631 |
| AHNAK | AHNAK nucleoprotein | 0.0578426 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.057799 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0571681 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0563299 |
| ECE1 | endothelin converting enzyme 1 | 0.0538832 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0533829 |
| MT2A | metallothionein 2A | 0.0470381 |
| CALR | calreticulin | 0.0451507 |
| COL5A1 | collagen, type V, alpha 1 | 0.0434654 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0422848 |
| EFNA5 | ephrin-A5 | 0.0374566 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0369427 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0365681 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0360599 |
| B2M | beta-2-microglobulin | 0.0323112 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0314683 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0309539 |
| PCBP2 | poly(rC) binding protein 2 | 0.0309407 |
| RPS12 | ribosomal protein S12 | 0.0295783 |
| RPS18 | ribosomal protein S18 | 0.0294585 |
| RPL3 | ribosomal protein L3 | 0.0291725 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0289913 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0288095 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0279224 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0275889 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0275423 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0274396 |
| COL3A1 | collagen, type III, alpha 1 | 0.0270975 |
| HLA-A | major histocompatibility complex, class I, A | 0.0265815 |
| HYOU1 | hypoxia up-regulated 1 | 0.0262144 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0250657 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0243156 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0237052 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0232166 |
| FAT1 | FAT atypical cadherin 1 | 0.0230553 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0229837 |
| OSMR | oncostatin M receptor | 0.0227699 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0227649 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0226095 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0225953 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0223394 |
| CANX | calnexin | 0.0220424 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0218487 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0217307 |
| RPS3 | ribosomal protein S3 | 0.0217179 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.021527 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0213749 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0209318 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0206532 |
| PKM | pyruvate kinase, muscle | 0.0206035 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0205853 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0202832 |
| PAPPA2 | pappalysin 2 | 0.0200544 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0198571 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0195859 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0195059 |
| ATF4 | activating transcription factor 4 | 0.0194043 |
| CFB | complement factor B | 0.0193426 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0192989 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0190535 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0189475 |
| WWOX | WW domain containing oxidoreductase | 0.0184583 |
| FBN1 | fibrillin 1 | 0.0184416 |
| NRP1 | neuropilin 1 | 0.0184345 |
| NAV1 | neuron navigator 1 | 0.0183883 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0181433 |
| TPM3 | tropomyosin 3 | 0.018056 |
| SQSTM1 | sequestosome 1 | 0.0180555 |
| FLNB | filamin B, beta | 0.0178933 |
| SEPTIN9 | septin 9 | 0.0176171 |
| C1R | complement component 1, r subcomponent | 0.0175126 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0173105 |
| CTSL | cathepsin L | 0.0172732 |
| PRELID2 | PRELI domain containing 2 | 0.0171639 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0169655 |
| HLA-C | major histocompatibility complex, class I, C | 0.0169403 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.016902 |
| NAV2 | neuron navigator 2 | 0.0168944 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0168214 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0167988 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0166522 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0166332 |
| SARS1 | seryl-tRNA synthetase 1 | 0.0166305 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.016502 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0165002 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0164882 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.016403 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0163164 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.325848 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.20886 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.187772 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.147483 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.117666 |
| FN1 | fibronectin 1 | -0.116484 |
| IER3 | immediate early response 3 | -0.103342 |
| LOX | lysyl oxidase | -0.100845 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.100457 |
| COL1A2 | collagen, type I, alpha 2 | -0.0924072 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0914695 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0854787 |
| VIM | vimentin | -0.0833973 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0793519 |
| ACTG1 | actin gamma 1 | -0.077297 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0769212 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0738796 |
| CADM1 | cell adhesion molecule 1 | -0.0713716 |
| CALD1 | caldesmon 1 | -0.0619842 |
| NDRG1 | N-myc downstream regulated 1 | -0.0592275 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0569621 |
| SPAG9 | sperm associated antigen 9 | -0.0532481 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0514451 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0499645 |
| CD44 | CD44 molecule (Indian blood group) | -0.0497181 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0493467 |
| GOLGA4 | golgin A4 | -0.0480418 |
| RPL35A | ribosomal protein L35a | -0.0468083 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.044548 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0435807 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0419438 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0411372 |
| ATP13A3 | ATPase type 13A3 | -0.0396569 |
| PTMA | prothymosin, alpha | -0.0395781 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0390511 |
| TMSB10 | thymosin beta 10 | -0.0388243 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0369756 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0356724 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0349454 |
| TMSB4X | thymosin beta 4, X-linked | -0.0343841 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.034077 |
| S100A9 | S100 calcium binding protein A9 | -0.0334667 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0333619 |
| RRBP1 | ribosome binding protein 1 | -0.0323455 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.031982 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0318429 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0309231 |
| ZNF292 | zinc finger protein 292 | -0.0308212 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0306658 |
| CAVIN1 | caveolae associated protein 1 | -0.0306477 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0305847 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0302629 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0300102 |
| TMEM263 | transmembrane protein 263 | -0.0287883 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0279081 |
| MTDH | metadherin | -0.0276943 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0276723 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0276095 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0275841 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0275366 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0274533 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0274086 |
| TFG | TRK-fused gene | -0.0273825 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0273139 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0269935 |
| CD109 | CD109 molecule | -0.0268727 |
| SEC24A | SEC24 family member A | -0.0268095 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0266533 |
| RLF | rearranged L-myc fusion | -0.0265157 |
| FRMD4A | FERM domain containing 4A | -0.0262618 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0262357 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0262056 |
| SEC24D | SEC24 family member D | -0.02615 |
| TRAM1 | translocation associated membrane protein 1 | -0.0260881 |
| INHBA | inhibin, beta A | -0.0250375 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0249496 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0247954 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0246938 |
| QKI | QKI, KH domain containing, RNA binding | -0.024623 |
| MRTFA | myocardin related transcription factor A | -0.0241106 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0238208 |
| POTEF | POTE ankyrin domain family, member F | -0.0236796 |
| ADM | adrenomedullin | -0.0234314 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0232575 |
| HIP1 | huntingtin interacting protein 1 | -0.0232488 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0228163 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0226112 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0220343 |
| COPA | coatomer protein complex, subunit alpha | -0.0219928 |
| RBM39 | RNA binding motif protein 39 | -0.0219401 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0216726 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0215339 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0214011 |
| CNTN5 | contactin 5 | -0.0211042 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.021003 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0209782 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0208669 |
| USP3 | ubiquitin specific peptidase 3 | -0.0207685 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0207676 |
| MYO10 | myosin X | -0.020682 |
