| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib (maleate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.206459 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.154072 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.110876 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.10939 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.106689 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.103786 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.100587 |
| C3 | complement component 3 | 0.0913154 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0903343 |
| DSPP | dentin sialophosphoprotein | 0.0888661 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0865536 |
| DST | dystonin | 0.0699601 |
| PCBP2 | poly(rC) binding protein 2 | 0.0699083 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0696464 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0680233 |
| FMNL2 | formin-like 2 | 0.0674652 |
| FAM107B | family with sequence similarity 107, member B | 0.0667416 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.066114 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0660129 |
| DTNA | dystrobrevin, alpha | 0.0657718 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0652783 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0652218 |
| SVIL | supervillin | 0.0648472 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0647975 |
| ATXN1 | ataxin 1 | 0.0597464 |
| SMAD3 | SMAD family member 3 | 0.0591073 |
| FOXP1 | forkhead box P1 | 0.0589204 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.058749 |
| TNS1 | tensin 1 | 0.0580956 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0545977 |
| KIF1B | kinesin family member 1B | 0.0543101 |
| VEGFA | vascular endothelial growth factor A | 0.054284 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0523827 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0504103 |
| LDHA | lactate dehydrogenase A | 0.049314 |
| PDLIM5 | PDZ and LIM domain 5 | 0.049163 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0481491 |
| TXNRD1 | thioredoxin reductase 1 | 0.0472399 |
| RAD51B | RAD51 paralog B | 0.0458223 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0455276 |
| UBC | ubiquitin C | 0.0439959 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0437427 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0435625 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0428768 |
| PLIN2 | perilipin 2 | 0.04283 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0417523 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0416295 |
| JMJD1C | jumonji domain containing 1C | 0.0409423 |
| GSE1 | Gse1 coiled-coil protein | 0.0403753 |
| KIAA1217 | KIAA1217 | 0.0402396 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0400165 |
| KYNU | kynureninase | 0.0398096 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.038499 |
| CCNY | cyclin Y | 0.0384591 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0382712 |
| PKM | pyruvate kinase, muscle | 0.0379529 |
| ANO6 | anoctamin 6 | 0.0379156 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0374123 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0373898 |
| POTEF | POTE ankyrin domain family, member F | 0.0368911 |
| FLNB | filamin B, beta | 0.0367419 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0348747 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.034496 |
| WWC2 | WW and C2 domain containing 2 | 0.0342826 |
| ANKRD11 | ankyrin repeat domain 11 | 0.03416 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0339597 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0338671 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0337249 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0335607 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0334475 |
| MCL1 | myeloid cell leukemia 1 | 0.033349 |
| MYO5B | myosin VB | 0.0329483 |
| FN1 | fibronectin 1 | 0.0325837 |
| MSI2 | musashi RNA-binding protein 2 | 0.0324916 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0320751 |
| SDC4 | syndecan 4 | 0.0320441 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0319642 |
| FAM219A | family with sequence similarity 219, member A | 0.0317545 |
| RAB10 | RAB10, member RAS oncogene family | 0.0317046 |
| ASPH | aspartate beta-hydroxylase | 0.0316304 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0312654 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0312441 |
| MYO1B | myosin IB | 0.03092 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0308553 |
| BRD4 | bromodomain containing 4 | 0.0308538 |
| TNS3 | tensin 3 | 0.0307362 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.030412 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0301927 |
| GK | glycerol kinase | 0.0301655 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0300257 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0300247 |
| RUNX1 | runt-related transcription factor 1 | 0.0299672 |
| ZNF638 | zinc finger protein 638 | 0.0297062 |
| PDE8A | phosphodiesterase 8A | 0.029488 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0290498 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0289197 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0288708 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0288703 |
| AHNAK | AHNAK nucleoprotein | 0.0287251 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0285229 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.181799 |
| APOB | apolipoprotein B | -0.168566 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.134908 |
| GPC3 | glypican 3 | -0.096609 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0907322 |
| RPL37A | ribosomal protein L37a | -0.0893865 |
| RPS12 | ribosomal protein S12 | -0.0856509 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.083203 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0772635 |
| TMSB10 | thymosin beta 10 | -0.076918 |
| A2M | alpha-2-macroglobulin | -0.0694774 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0554242 |
| RPS19 | ribosomal protein S19 | -0.0552367 |
| RPL9 | ribosomal protein L9 | -0.0550312 |
| TRIM26 | tripartite motif containing 26 | -0.0543359 |
| RPL11 | ribosomal protein L11 | -0.0540214 |
| RPS24 | ribosomal protein S24 | -0.0536586 |
| RPL31 | ribosomal protein L31 | -0.0520905 |
| MT2A | metallothionein 2A | -0.052016 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0505507 |
| RPL23 | ribosomal protein L23 | -0.0502972 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0494065 |
| RPS8 | ribosomal protein S8 | -0.0483134 |
| RPL26 | ribosomal protein L26 | -0.0477088 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0476835 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0466059 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0464758 |
| RPS6 | ribosomal protein S6 | -0.0461594 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0450136 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0446516 |
| RPS27A | ribosomal protein S27a | -0.0440325 |
| PTCHD4 | patched domain containing 4 | -0.0437321 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0434568 |
| RPL35A | ribosomal protein L35a | -0.0415741 |
| RPS3 | ribosomal protein S3 | -0.0415307 |
| RPS17 | ribosomal protein S17 | -0.0409221 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0400663 |
| RPL37 | ribosomal protein L37 | -0.0397115 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0389506 |
| RACK1 | receptor for activated C kinase 1 | -0.0385608 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0380578 |
| RPL34 | ribosomal protein L34 | -0.0355889 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0350003 |
| RPL12 | ribosomal protein L12 | -0.0338032 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0330793 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.033042 |
| EHBP1 | EH domain binding protein 1 | -0.0326388 |
| RPS21 | ribosomal protein S21 | -0.0321679 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0321527 |
| CFB | complement factor B | -0.0310501 |
| RPL36 | ribosomal protein L36 | -0.03105 |
| PEG3 | paternally expressed 3 | -0.0301855 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0288824 |
| IER3 | immediate early response 3 | -0.028224 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0278079 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0277913 |
| RPL18 | ribosomal protein L18 | -0.0274206 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0269493 |
| NPR2 | natriuretic peptide receptor 2 | -0.0268257 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0262527 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0262319 |
| RPS13 | ribosomal protein S13 | -0.0254827 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0254259 |
| PTMA | prothymosin, alpha | -0.0251223 |
| EGR1 | early growth response 1 | -0.0249754 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0249179 |
| FERMT1 | fermitin family member 1 | -0.0247064 |
| RPL30 | ribosomal protein L30 | -0.0246339 |
| RIGI | RNA sensor RIG-I | -0.0245579 |
| RPLP2 | ribosomal protein, large, P2 | -0.0241414 |
| NCOA7 | nuclear receptor coactivator 7 | -0.024139 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0240938 |
| PLAC8 | placenta-specific 8 | -0.0237018 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0236595 |
| AHSG | alpha-2-HS-glycoprotein | -0.0234669 |
| ITGAV | integrin, alpha V | -0.0230044 |
| APOE | apolipoprotein E | -0.0225284 |
| DOK6 | docking protein 6 | -0.0223314 |
| VCAN | versican | -0.0221091 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0219862 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0219268 |
| RPL27 | ribosomal protein L27 | -0.021914 |
| MX2 | MX dynamin-like GTPase 2 | -0.021886 |
| RPL13A | ribosomal protein L13a | -0.0218646 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0217065 |
| RPS25 | ribosomal protein S25 | -0.0216846 |
| FTL | ferritin, light polypeptide | -0.0216184 |
| RPL10A | ribosomal protein L10a | -0.0213846 |
| CALD1 | caldesmon 1 | -0.0211861 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0204589 |
| SYN3 | synapsin III | -0.0203646 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0201931 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0198504 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0197827 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0196559 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0194722 |
| HLF | hepatic leukemia factor | -0.0194569 |
| RPLP0 | ribosomal protein, large, P0 | -0.0193576 |
| LYZ | lysozyme | -0.0192995 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0192952 |
