| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.138701 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.134665 |
| AHNAK | AHNAK nucleoprotein | 0.132607 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.119778 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0964007 |
| FHIT | fragile histidine triad | 0.0930836 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0901064 |
| RAD51B | RAD51 paralog B | 0.0876357 |
| MAP1B | microtubule-associated protein 1B | 0.0705049 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.066582 |
| NAV2 | neuron navigator 2 | 0.0651295 |
| FLNB | filamin B, beta | 0.0640628 |
| SQSTM1 | sequestosome 1 | 0.0638317 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0636213 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0615313 |
| ENO1 | enolase 1, (alpha) | 0.0602291 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0594713 |
| PRELID2 | PRELI domain containing 2 | 0.0588459 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0575225 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0575096 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0566625 |
| FLNA | filamin A, alpha | 0.0565901 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0549636 |
| PCBP2 | poly(rC) binding protein 2 | 0.0544757 |
| TPD52 | tumor protein D52 | 0.0541988 |
| PLEC | plectin | 0.0535938 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0534375 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0531119 |
| WWOX | WW domain containing oxidoreductase | 0.0528731 |
| PKM | pyruvate kinase, muscle | 0.0527196 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0527023 |
| ZNF148 | zinc finger protein 148 | 0.0526808 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0507922 |
| DST | dystonin | 0.0500671 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0496304 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0495122 |
| RNF213 | ring finger protein 213 | 0.0492174 |
| POTEF | POTE ankyrin domain family, member F | 0.0490851 |
| ASPH | aspartate beta-hydroxylase | 0.0478931 |
| AXL | AXL receptor tyrosine kinase | 0.046611 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0465932 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0462034 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.046018 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0455 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.045056 |
| CANX | calnexin | 0.0449278 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0444752 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0441713 |
| SEPTIN9 | septin 9 | 0.0439545 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.043612 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0424402 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0419307 |
| APP | amyloid beta (A4) precursor protein | 0.0408328 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0406189 |
| KRT7 | keratin 7, type II | 0.0405736 |
| TPM3 | tropomyosin 3 | 0.040172 |
| PFKP | phosphofructokinase, platelet | 0.0396427 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0389664 |
| EGFR | epidermal growth factor receptor | 0.0382792 |
| MSN | moesin | 0.0378779 |
| COL5A1 | collagen, type V, alpha 1 | 0.0377288 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0376213 |
| TBC1D5 | TBC1 domain family, member 5 | 0.037475 |
| CEP250 | centrosomal protein 250kDa | 0.0372836 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0372107 |
| NCOA6 | nuclear receptor coactivator 6 | 0.0360849 |
| SMAD3 | SMAD family member 3 | 0.0358542 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0358189 |
| ADM | adrenomedullin | 0.0355277 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.03537 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0353071 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0349763 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0349519 |
| MAP4 | microtubule-associated protein 4 | 0.0348899 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0346713 |
| LDHA | lactate dehydrogenase A | 0.0345857 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0342517 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0341025 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.033988 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0338647 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0337125 |
| ANXA2 | annexin A2 | 0.0336827 |
| XPO1 | exportin 1 | 0.0334937 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0334258 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0334059 |
| ERBIN | erbb2 interacting protein | 0.033228 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0331921 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0329857 |
| SMYD3 | SET and MYND domain containing 3 | 0.032902 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0327191 |
| CTTN | cortactin | 0.0325055 |
| YEATS2 | YEATS domain containing 2 | 0.0324409 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0320736 |
| EXOC4 | exocyst complex component 4 | 0.0316465 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0314436 |
| LOXL2 | lysyl oxidase-like 2 | 0.0313898 |
| BCL2L1 | BCL2-like 1 | 0.0313363 |
| ATXN1 | ataxin 1 | 0.03111 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0306315 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0303491 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.414331 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.114871 |
| EXT1 | exostosin glycosyltransferase 1 | -0.109844 |
| MT2A | metallothionein 2A | -0.100743 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0986552 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0800937 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0766585 |
| GLIS3 | GLIS family zinc finger 3 | -0.0620498 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0600335 |
| HLA-B | major histocompatibility complex, class I, B | -0.0477241 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.045534 |
| TMSB10 | thymosin beta 10 | -0.04355 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0432009 |
| INTS6 | integrator complex subunit 6 | -0.0413795 |
| TLE4 | transducin-like enhancer of split 4 | -0.0396079 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0391359 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0383867 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0361676 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0355721 |
| VCL | vinculin | -0.031333 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0299486 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0290701 |
| RPS3 | ribosomal protein S3 | -0.0290057 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0283983 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0270504 |
| TGFB2 | transforming growth factor, beta 2 | -0.0267818 |
| NDRG1 | N-myc downstream regulated 1 | -0.025431 |
| NABP1 | nucleic acid binding protein 1 | -0.025339 |
| HLA-A | major histocompatibility complex, class I, A | -0.0246062 |
| DTNA | dystrobrevin, alpha | -0.0245296 |
| RPS19 | ribosomal protein S19 | -0.0245021 |
| MT1X | metallothionein 1X | -0.0243328 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.024123 |
| LOX | lysyl oxidase | -0.0240417 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0238915 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0235512 |
| RPL26 | ribosomal protein L26 | -0.0233903 |
| POSTN | periostin, osteoblast specific factor | -0.0232468 |
| CAST | calpastatin | -0.0221429 |
| CUL4B | cullin 4B | -0.0219327 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0218537 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0217645 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0215864 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.021418 |
| SULF1 | sulfatase 1 | -0.0213637 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0213331 |
| ZNF804A | zinc finger protein 804A | -0.0207074 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0206948 |
| RPL37 | ribosomal protein L37 | -0.0206072 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.020527 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0202973 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0200047 |
| FRMD4A | FERM domain containing 4A | -0.0198865 |
| BMPER | BMP binding endothelial regulator | -0.0198526 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0196106 |
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | -0.0192512 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0190207 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0184527 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0183625 |
| ITGA1 | integrin, alpha 1 | -0.018292 |
| PFN1 | profilin 1 | -0.0179706 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0178114 |
| RPL30 | ribosomal protein L30 | -0.017601 |
| VEGFC | vascular endothelial growth factor C | -0.0175374 |
| RPL9 | ribosomal protein L9 | -0.0174875 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0174127 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0172527 |
| TMSB4X | thymosin beta 4, X-linked | -0.0172197 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0172009 |
| RPS17 | ribosomal protein S17 | -0.0171829 |
| RPL35A | ribosomal protein L35a | -0.0170818 |
| GLRX | glutaredoxin (thioltransferase) | -0.0170184 |
| RPL34 | ribosomal protein L34 | -0.0169582 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.016751 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0166889 |
| RPL11 | ribosomal protein L11 | -0.0166714 |
| VGLL3 | vestigial-like family member 3 | -0.0166414 |
| RPL36 | ribosomal protein L36 | -0.016638 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0165693 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0163313 |
| HMGB1 | high mobility group box 1 | -0.016303 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0162479 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0162196 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0161675 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.01615 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0157981 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0153244 |
| CCDC80 | coiled-coil domain containing 80 | -0.0152922 |
| RPL37A | ribosomal protein L37a | -0.0150949 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0147041 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0145598 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.01429 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0142876 |
| RACK1 | receptor for activated C kinase 1 | -0.0142076 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.014092 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0140075 |
| RPL5 | ribosomal protein L5 | -0.0140058 |
| PTX3 | pentraxin 3, long | -0.0138167 |
| VIM | vimentin | -0.0135901 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0135171 |
