| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | 0.116441 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.10257 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0968341 |
| PCBP2 | poly(rC) binding protein 2 | 0.0907177 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0870724 |
| EZR | ezrin | 0.0801757 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0793219 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0788801 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0765275 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0748502 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0734416 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.070158 |
| CALB1 | calbindin 1, 28kDa | 0.0667441 |
| TXNRD1 | thioredoxin reductase 1 | 0.0634719 |
| FAT1 | FAT atypical cadherin 1 | 0.061704 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0574057 |
| PCDHB16 | protocadherin beta 16 | 0.0549923 |
| RPS18 | ribosomal protein S18 | 0.0530486 |
| RPL3 | ribosomal protein L3 | 0.052019 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0509052 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0487912 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0472689 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0469589 |
| CANX | calnexin | 0.0464662 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0446778 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0442847 |
| MYO5B | myosin VB | 0.0442773 |
| CCPG1 | cell cycle progression 1 | 0.0433651 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0422522 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0409955 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0409303 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0408617 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0406385 |
| ITGA6 | integrin, alpha 6 | 0.0405865 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0396883 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0392678 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.038877 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0387199 |
| XPOT | exportin, tRNA | 0.0387112 |
| ASPH | aspartate beta-hydroxylase | 0.0375613 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0370766 |
| CLDN4 | claudin 4 | 0.03692 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0368522 |
| HKDC1 | hexokinase domain containing 1 | 0.0368105 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0357844 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0357668 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0353077 |
| TCF12 | transcription factor 12 | 0.0352941 |
| PRELID2 | PRELI domain containing 2 | 0.0346364 |
| SETD5 | SET domain containing 5 | 0.0342731 |
| LDHA | lactate dehydrogenase A | 0.0342629 |
| RPS12 | ribosomal protein S12 | 0.0341393 |
| NDRG1 | N-myc downstream regulated 1 | 0.0339749 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.033215 |
| GOLGA4 | golgin A4 | 0.0325462 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0322972 |
| PKM | pyruvate kinase, muscle | 0.0321672 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0319001 |
| KLF6 | Kruppel-like factor 6 | 0.0317306 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.031538 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0310932 |
| AFDN | afadin, adherens junction formation factor | 0.0310889 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0309082 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0306086 |
| RAD51B | RAD51 paralog B | 0.0305966 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0304477 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0304416 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0304098 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0303599 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0299659 |
| MAP4 | microtubule-associated protein 4 | 0.0299463 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0298503 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0296663 |
| EREG | epiregulin | 0.029636 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0295604 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0294759 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0292368 |
| ANXA11 | annexin A11 | 0.029021 |
| MED13L | mediator complex subunit 13-like | 0.0289134 |
| TPM3 | tropomyosin 3 | 0.0288934 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0288087 |
| SEPTIN10 | septin 10 | 0.0286633 |
| TMEM41B | transmembrane protein 41B | 0.028629 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.028408 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0283997 |
| PDE8A | phosphodiesterase 8A | 0.0282497 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0281292 |
| AREG | amphiregulin | 0.0281023 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0280715 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0278976 |
| RTN4 | reticulon 4 | 0.027744 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0276664 |
| TRIM2 | tripartite motif containing 2 | 0.0275304 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0274821 |
| RNF213 | ring finger protein 213 | 0.0273667 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0273423 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0271569 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0270984 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0270713 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0269761 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.14184 |
| RPLP1 | ribosomal protein, large, P1 | -0.124913 |
| LMO7 | LIM domain 7 | -0.100537 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0997922 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0968298 |
| MYO1E | myosin IE | -0.0775629 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0770947 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0760514 |
| RPL35A | ribosomal protein L35a | -0.0680115 |
| RPS6 | ribosomal protein S6 | -0.0655203 |
| RPL34 | ribosomal protein L34 | -0.0632264 |
| RPS8 | ribosomal protein S8 | -0.0626465 |
| RPS19 | ribosomal protein S19 | -0.0616997 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0561018 |
| INTS6 | integrator complex subunit 6 | -0.0518993 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.051029 |
| RPLP2 | ribosomal protein, large, P2 | -0.0493564 |
| RPS23 | ribosomal protein S23 | -0.048119 |
| TMSB10 | thymosin beta 10 | -0.046708 |
| RPS24 | ribosomal protein S24 | -0.0465704 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0450705 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0430417 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.04287 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.041364 |
| RPL23 | ribosomal protein L23 | -0.0402319 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0372946 |
| RPL12 | ribosomal protein L12 | -0.0370998 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0366545 |
| PTMA | prothymosin, alpha | -0.0364423 |
| RPS25 | ribosomal protein S25 | -0.0354291 |
| RPS29 | ribosomal protein S29 | -0.0353008 |
| MUC13 | mucin 13, cell surface associated | -0.0349223 |
| RPL32 | ribosomal protein L32 | -0.033964 |
| RPS16 | ribosomal protein S16 | -0.0331551 |
| ACTG1 | actin gamma 1 | -0.0330225 |
| RPS11 | ribosomal protein S11 | -0.0324677 |
| HLA-B | major histocompatibility complex, class I, B | -0.0313408 |
| LRRC23 | leucine rich repeat containing 23 | -0.0301958 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0300351 |
| NABP1 | nucleic acid binding protein 1 | -0.0297771 |
| RPL28 | ribosomal protein L28 | -0.0289704 |
| RPS15 | ribosomal protein S15 | -0.0289547 |
| NPSR1 | neuropeptide S receptor 1 | -0.0285883 |
| RPL37A | ribosomal protein L37a | -0.0284829 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0280809 |
| RPS27A | ribosomal protein S27a | -0.0275976 |
| RPL9 | ribosomal protein L9 | -0.0275303 |
| IRF1 | interferon regulatory factor 1 | -0.0274873 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0273376 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.025672 |
| RPL19 | ribosomal protein L19 | -0.0256231 |
| RPL38 | ribosomal protein L38 | -0.0254334 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.025226 |
| TSPAN8 | tetraspanin 8 | -0.0251266 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0246798 |
| FRMD5 | FERM domain containing 5 | -0.0239356 |
| RPS21 | ribosomal protein S21 | -0.0238934 |
| AGR2 | anterior gradient 2 | -0.0236675 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0236306 |
| RPL8 | ribosomal protein L8 | -0.0230587 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.021937 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0213641 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0212327 |
| RPL4 | ribosomal protein L4 | -0.0207351 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.020464 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0204447 |
| RPL5 | ribosomal protein L5 | -0.0203502 |
| RPS10 | ribosomal protein S10 | -0.0203413 |
| RPL35 | ribosomal protein L35 | -0.0202555 |
| FUS | FUS RNA binding protein | -0.0200853 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.019798 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0196968 |
| EGFR | epidermal growth factor receptor | -0.0194611 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.019177 |
| RPL36 | ribosomal protein L36 | -0.0190882 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0190742 |
| RPS5 | ribosomal protein S5 | -0.0188582 |
| RPS20 | ribosomal protein S20 | -0.0187875 |
| RPL27A | ribosomal protein L27a | -0.0184366 |
| RPLP0 | ribosomal protein, large, P0 | -0.018303 |
| CLIC5 | chloride intracellular channel 5 | -0.0182907 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0181222 |
| TC2N | tandem C2 domains, nuclear | -0.0179786 |
| RPS17 | ribosomal protein S17 | -0.0177888 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0176703 |
| HMGB1 | high mobility group box 1 | -0.0175331 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0174809 |
| S100A9 | S100 calcium binding protein A9 | -0.0172294 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0168581 |
| RPL31 | ribosomal protein L31 | -0.0164614 |
| RPL36A | ribosomal protein L36a | -0.0164408 |
| MTAP | methylthioadenosine phosphorylase | -0.0163241 |
| RPL7 | ribosomal protein L7 | -0.016083 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0160734 |
| RPS14 | ribosomal protein S14 | -0.015925 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0158147 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0157856 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0156999 |
| RPS13 | ribosomal protein S13 | -0.0155586 |
| IER3 | immediate early response 3 | -0.015378 |
