Neratinib (maleate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.187102
EZR ezrin 0.185029
DST dystonin 0.175992
PSD3 pleckstrin and Sec7 domain containing 3 0.148476
PODXL podocalyxin-like 0.0950622
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0933535
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0920209
EEF2 eukaryotic translation elongation factor 2 0.0912762
POTEF POTE ankyrin domain family, member F 0.0912099
MACF1 microtubule-actin crosslinking factor 1 0.0895206
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0869063
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.081796
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0761822
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0742057
RAB27B RAB27B, member RAS oncogene family 0.0701785
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0700467
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0670552
AHNAK AHNAK nucleoprotein 0.0637195
KLF6 Kruppel-like factor 6 0.0607538
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0603651
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0592096
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0583309
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0574258
RAI1 retinoic acid induced 1 0.0555239
ERRFI1 ERBB receptor feedback inhibitor 1 0.054383
RPS18 ribosomal protein S18 0.0542681
RTN4 reticulon 4 0.0540506
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0540072
FLNB filamin B, beta 0.0536839
TPM4 tropomyosin 4 0.0518608
MYH9 myosin, heavy chain 9, non-muscle 0.0510041
EMP1 epithelial membrane protein 1 0.049698
DPYSL2 dihydropyrimidinase-like 2 0.0493313
UBC ubiquitin C 0.0491672
AHNAK2 AHNAK nucleoprotein 2 0.0485438
TPM3 tropomyosin 3 0.0463339
KRT18 keratin 18, type I 0.0461868
PCBP2 poly(rC) binding protein 2 0.0455661
EREG epiregulin 0.0448703
BCAR3 breast cancer anti-estrogen resistance 3 0.044557
HMGA1 high mobility group AT-hook 1 0.0440194
CSNK1A1 casein kinase 1, alpha 1 0.0436404
PYGB phosphorylase, glycogen; brain 0.0434424
PRELID2 PRELI domain containing 2 0.0430513
ENO1 enolase 1, (alpha) 0.0424267
LDHA lactate dehydrogenase A 0.0415711
LOXL2 lysyl oxidase-like 2 0.0415368
ANXA2 annexin A2 0.0410468
S100A6 S100 calcium binding protein A6 0.0409654
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0402097
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0390222
RGS4 regulator of G-protein signaling 4 0.038247
SPAG9 sperm associated antigen 9 0.0372684
MYOF myoferlin 0.036503
CAPN2 calpain 2, (m/II) large subunit 0.0364836
FERMT1 fermitin family member 1 0.0364691
ZBTB38 zinc finger and BTB domain containing 38 0.035621
TRIO trio Rho guanine nucleotide exchange factor 0.035524
CAPRIN2 caprin family member 2 0.0352692
GARS1 glycyl-tRNA synthetase 1 0.035205
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0350364
PLK2 polo-like kinase 2 0.0336578
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0334667
FMNL2 formin-like 2 0.0334474
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0333605
PKM pyruvate kinase, muscle 0.0332288
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0328916
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0325988
PLEC plectin 0.0325202
JUN jun proto-oncogene 0.0319519
S100A11 S100 calcium binding protein A11 0.031616
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0314792
CDCP1 CUB domain containing protein 1 0.031376
NIBAN2 niban apoptosis regulator 2 0.0307441
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0304067
RAP2B RAP2B, member of RAS oncogene family 0.0303608
FER fer (fps/fes related) tyrosine kinase 0.0288821
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0283689
BIRC3 baculoviral IAP repeat containing 3 0.0280292
PYGL phosphorylase, glycogen, liver 0.0279818
RPL3 ribosomal protein L3 0.0278198
VIM vimentin 0.027474
HOOK2 hook microtubule-tethering protein 2 0.0273246
KRT8 keratin 8, type II 0.0273059
CFAP299 cilia and flagella associated protein 299 0.0270719
NFE2L1 nuclear factor, erythroid 2-like 1 0.0260241
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0259511
NAV1 neuron navigator 1 0.0258896
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0256188
APP amyloid beta (A4) precursor protein 0.025492
DARS1 aspartyl-tRNA synthetase 1 0.025489
ZFP36L1 ZFP36 ring finger protein-like 1 0.0254407
JMJD1C jumonji domain containing 1C 0.0252954
GCLM glutamate-cysteine ligase, modifier subunit 0.025172
PGK1 phosphoglycerate kinase 1 0.025169
SRRM2 serine/arginine repetitive matrix 2 0.025129
CMIP c-Maf inducing protein 0.0248837
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0246982
IQGAP1 IQ motif containing GTPase activating protein 1 0.0245003
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0244183

decreased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.149399
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142436
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.107292
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.087635
TP63 tumor protein p63 -0.0821387
PTMA prothymosin, alpha -0.0777685
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0755473
MT2A metallothionein 2A -0.06719
RPL35A ribosomal protein L35a -0.0634998
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0625119
HLA-B major histocompatibility complex, class I, B -0.0622869
DLG1 discs, large homolog 1 (Drosophila) -0.0587651
EHBP1 EH domain binding protein 1 -0.0572467
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.055719
RIGI RNA sensor RIG-I -0.0523596
TPT1 tumor protein, translationally-controlled 1 -0.0523326
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.051487
SRGN serglycin -0.049665
IFIH1 interferon induced with helicase C domain 1 -0.0478687
WSB1 WD repeat and SOCS box containing 1 -0.0475079
SOD2 superoxide dismutase 2, mitochondrial -0.0462582
TNS3 tensin 3 -0.0438819
CD44 CD44 molecule (Indian blood group) -0.0438003
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0415904
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0407544
RPL23 ribosomal protein L23 -0.0387152
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0386841
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.037371
PTK2 protein tyrosine kinase 2 -0.0360093
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0352915
TMSB4X thymosin beta 4, X-linked -0.0343401
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0336419
DPH6 diphthamine biosynthesis 6 -0.0329618
ZMYND8 zinc finger, MYND-type containing 8 -0.0317808
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0307342
EFNA5 ephrin-A5 -0.0306208
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0305995
DPYD dihydropyrimidine dehydrogenase -0.0298725
KMT2E lysine (K)-specific methyltransferase 2E -0.0285129
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.02826
MT1X metallothionein 1X -0.0280898
TMSB10 thymosin beta 10 -0.0277754
SP100 SP100 nuclear antigen -0.0277733
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0274269
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0269065
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0265983
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.026297
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0256954
RPS6 ribosomal protein S6 -0.0256087
ZNF292 zinc finger protein 292 -0.0255867
PIAS2 protein inhibitor of activated STAT, 2 -0.0253182
PMP22 peripheral myelin protein 22 -0.0248177
RPS19 ribosomal protein S19 -0.024404
RPL26 ribosomal protein L26 -0.0243222
MT1E metallothionein 1E -0.0243115
WARS1 tryptophanyl-tRNA synthetase 1 -0.0242484
TRA2A transformer 2 alpha homolog (Drosophila) -0.0241967
LOC102724023 ES1 protein homolog, mitochondrial -0.0236812
VCL vinculin -0.0231738
FNDC3B fibronectin type III domain containing 3B -0.0230986
MCTP1 multiple C2 domains, transmembrane 1 -0.0230479
PLSCR1 phospholipid scramblase 1 -0.0227964
RPL31 ribosomal protein L31 -0.0224436
RPL34 ribosomal protein L34 -0.0222961
CADM2 cell adhesion molecule 2 -0.0217103
LRRC49 leucine rich repeat containing 49 -0.0215634
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0214764
RPL36 ribosomal protein L36 -0.0212549
SMC4 structural maintenance of chromosomes 4 -0.0212143
ARL4C ADP-ribosylation factor-like 4C -0.0211115
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0208257
DENND5B DENN/MADD domain containing 5B -0.0207271
LRP1B low density lipoprotein receptor-related protein 1B -0.0206476
INTS6 integrator complex subunit 6 -0.0206019
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.020596
EPB41 erythrocyte membrane protein band 4.1 -0.0204639
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0204249
ANGPTL4 angiopoietin-like 4 -0.0203942
RPS24 ribosomal protein S24 -0.0200508
TTC3 tetratricopeptide repeat domain 3 -0.0200193
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0199722
NAMPT nicotinamide phosphoribosyltransferase -0.0195537
PGAP1 post-GPI attachment to proteins 1 -0.0194476
RPS29 ribosomal protein S29 -0.0192598
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0190794
BMERB1 bMERB domain containing 1 -0.0190526
PNISR PNN-interacting serine/arginine-rich protein -0.0189075
RPL9 ribosomal protein L9 -0.0187591
COL5A2 collagen, type V, alpha 2 -0.0186589
ETV6 ets variant 6 -0.0184795
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0183692
TOP2A topoisomerase (DNA) II alpha 170kDa -0.018327
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.018305
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0182467
ARHGAP5 Rho GTPase activating protein 5 -0.0181551
XAF1 XIAP associated factor 1 -0.0181387
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0178942
STK17A serine/threonine kinase 17a -0.0178174
RPL12 ribosomal protein L12 -0.0176497
NAP1L1 nucleosome assembly protein 1-like 1 -0.0175763