Neratinib (maleate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Neratinib (maleate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.175536
PDE4D phosphodiesterase 4D, cAMP-specific 0.128272
MYOF myoferlin 0.11038
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0973831
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.095875
IGFBP5 insulin-like growth factor binding protein 5 0.09377
PCBP2 poly(rC) binding protein 2 0.0896179
PM20D1 peptidase M20 domain containing 1 0.0857578
DSPP dentin sialophosphoprotein 0.0847508
CPE carboxypeptidase E 0.0652799
RNF213 ring finger protein 213 0.0639443
S100P S100 calcium binding protein P 0.0638387
GRAMD1B GRAM domain containing 1B 0.0623717
CES1 carboxylesterase 1 0.0617426
GCLC glutamate-cysteine ligase, catalytic subunit 0.060019
RPS3 ribosomal protein S3 0.0559322
IRS2 insulin receptor substrate 2 0.0552778
LMO7 LIM domain 7 0.055094
TOP1 topoisomerase (DNA) I 0.0540842
FTL ferritin, light polypeptide 0.0525967
MACF1 microtubule-actin crosslinking factor 1 0.0524005
SVIL supervillin 0.0498498
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0494173
RIMS2 regulating synaptic membrane exocytosis 2 0.049239
SPAG9 sperm associated antigen 9 0.0482338
NTN4 netrin 4 0.0469921
TBC1D22A TBC1 domain family, member 22A 0.045391
HYOU1 hypoxia up-regulated 1 0.0448389
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.043191
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0430805
RPS12 ribosomal protein S12 0.0424807
ELL2 elongation factor, RNA polymerase II, 2 0.0424138
DOCK5 dedicator of cytokinesis 5 0.04225
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0405862
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0404678
MLPH melanophilin 0.039932
EEF2 eukaryotic translation elongation factor 2 0.039848
KIAA0319 KIAA0319 0.0397523
RPL3 ribosomal protein L3 0.0397443
ZC3H12B zinc finger CCCH-type containing 12B 0.039704
PLEC plectin 0.0386649
LIMCH1 LIM and calponin homology domains 1 0.0382669
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0381665
CTNND1 catenin (cadherin-associated protein), delta 1 0.0379395
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0374037
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0373323
ENO1 enolase 1, (alpha) 0.0366579
DSCAM Down syndrome cell adhesion molecule 0.0357859
MYH9 myosin, heavy chain 9, non-muscle 0.0357408
WWOX WW domain containing oxidoreductase 0.0354223
JAK1 Janus kinase 1 0.0350647
MYO5B myosin VB 0.0339528
BCAR3 breast cancer anti-estrogen resistance 3 0.0331136
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0330803
SMAD3 SMAD family member 3 0.0330114
UBC ubiquitin C 0.0329372
AGO2 argonaute RISC catalytic component 2 0.0328061
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0322042
TES testin LIM domain protein 0.0312083
UGDH UDP-glucose 6-dehydrogenase 0.0309534
DTNB dystrobrevin, beta 0.0305313
ANKRD11 ankyrin repeat domain 11 0.0305035
GOLGB1 golgin B1 0.028824
KRT80 keratin 80, type II 0.0284984
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0283954
NFE2L1 nuclear factor, erythroid 2-like 1 0.0282625
CANX calnexin 0.0281618
APP amyloid beta (A4) precursor protein 0.0280707
HDLBP high density lipoprotein binding protein 0.0277767
EPAS1 endothelial PAS domain protein 1 0.0275505
BMP6 bone morphogenetic protein 6 0.0275317
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0274918
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0273831
MAP7 microtubule-associated protein 7 0.0273331
LDHA lactate dehydrogenase A 0.0271933
ATOSA atos homolog A 0.0268684
CALR calreticulin 0.0267798
SRRM2 serine/arginine repetitive matrix 2 0.0267726
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0265141
MED13L mediator complex subunit 13-like 0.0263185
LRP12 low density lipoprotein receptor-related protein 12 0.0260862
DTNA dystrobrevin, alpha 0.0258672
CAMTA1 calmodulin binding transcription activator 1 0.0257037
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0256822
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0254533
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0253588
EIF1 eukaryotic translation initiation factor 1 0.0253165
NAP1L1 nucleosome assembly protein 1-like 1 0.0249104
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0246641
CTBP2 C-terminal binding protein 2 0.0245371
DHFR dihydrofolate reductase 0.0245248
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0243217
NEBL nebulette 0.0241059
PDE8A phosphodiesterase 8A 0.0237903
PTPRD protein tyrosine phosphatase, receptor type, D 0.0236991
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.023302
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0232792
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0231613
MARS1 methionyl-tRNA synthetase 1 0.0230862
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.02281

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.225013
LAMC2 laminin, gamma 2 -0.152752
PTPRM protein tyrosine phosphatase, receptor type, M -0.142526
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137647
ACTG1 actin gamma 1 -0.131792
CAV1 caveolin 1, caveolae protein, 22kDa -0.122264
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.108612
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.106046
OSMR oncostatin M receptor -0.09259
THSD4 thrombospondin, type I, domain containing 4 -0.0872391
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0838424
ZMYND8 zinc finger, MYND-type containing 8 -0.0829581
NDRG1 N-myc downstream regulated 1 -0.0818956
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0806762
EFNA5 ephrin-A5 -0.0793546
STC1 stanniocalcin 1 -0.0760972
S100A10 S100 calcium binding protein A10 -0.0750904
MCTP1 multiple C2 domains, transmembrane 1 -0.071599
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0711733
MT2A metallothionein 2A -0.0663887
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0658749
EGFR epidermal growth factor receptor -0.0656949
SOD2 superoxide dismutase 2, mitochondrial -0.0652546
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0639224
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0601135
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0585473
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0573144
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0557096
LAMA4 laminin, alpha 4 -0.0541572
LRP1B low density lipoprotein receptor-related protein 1B -0.0539016
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0475871
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.04685
RIN2 Ras and Rab interactor 2 -0.0466503
ATG7 autophagy related 7 -0.0460642
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0454058
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0442831
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0431585
TPT1 tumor protein, translationally-controlled 1 -0.0426848
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0411359
NAMPT nicotinamide phosphoribosyltransferase -0.0411296
PATJ PATJ crumbs cell polarity complex component -0.0405285
MYO1D myosin ID -0.0403554
NABP1 nucleic acid binding protein 1 -0.0403078
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0393364
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.03832
SP100 SP100 nuclear antigen -0.038278
PARD3 par-3 family cell polarity regulator -0.0381994
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0374006
B2M beta-2-microglobulin -0.0368656
CST3 cystatin C -0.0366856
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0366334
NRIP1 nuclear receptor interacting protein 1 -0.0358146
HLA-B major histocompatibility complex, class I, B -0.035674
MAML2 mastermind-like 2 (Drosophila) -0.033797
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0334032
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0332632
CD99 CD99 molecule -0.03315
KLF5 Kruppel-like factor 5 (intestinal) -0.0330499
PRKCA protein kinase C, alpha -0.0324165
CDCP1 CUB domain containing protein 1 -0.0321725
RPL35A ribosomal protein L35a -0.0319167
PRRC2C proline-rich coiled-coil 2C -0.0317852
S100A9 S100 calcium binding protein A9 -0.0316645
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0313423
MX1 MX dynamin-like GTPase 1 -0.0310868
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0310033
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308196
RAB1A RAB1A, member RAS oncogene family -0.0307319
GSK3B glycogen synthase kinase 3 beta -0.0303445
H1-0 H1.0 linker histone -0.0299126
BMAL2 basic helix-loop-helix ARNT like 2 -0.0298746
BTG1 B-cell translocation gene 1, anti-proliferative -0.029736
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0295243
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0294858
TRAF3 TNF receptor-associated factor 3 -0.0294489
EGR1 early growth response 1 -0.0292302
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.028929
AKR1C1 aldo-keto reductase family 1, member C1 -0.0277743
AREG amphiregulin -0.0277476
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0277056
PTMA prothymosin, alpha -0.026976
TPM4 tropomyosin 4 -0.0263998
S100A6 S100 calcium binding protein A6 -0.0263247
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0262663
RIGI RNA sensor RIG-I -0.0262103
ITGA6 integrin, alpha 6 -0.0260299
KRT8 keratin 8, type II -0.0259552
VEGFC vascular endothelial growth factor C -0.0256773
GPC6 glypican 6 -0.0255702
DISC1 disrupted in schizophrenia 1 -0.0255659
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0255164
KRT18 keratin 18, type I -0.0254506
NCOA7 nuclear receptor coactivator 7 -0.0252858
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0250139
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.024837
S100A11 S100 calcium binding protein A11 -0.0247396
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0239412
EHBP1 EH domain binding protein 1 -0.0239043
IER3 immediate early response 3 -0.0238462
KDM2A lysine (K)-specific demethylase 2A -0.0233434