Neratinib (maleate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.162826
SDK1 sidekick cell adhesion molecule 1 0.104442
NAMPT nicotinamide phosphoribosyltransferase 0.0999083
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.097884
GRB10 growth factor receptor-bound protein 10 0.0973624
SMAD3 SMAD family member 3 0.0877682
FAM13A family with sequence similarity 13, member A 0.0842628
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0838733
NAV2 neuron navigator 2 0.0819885
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0817118
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0809575
PRELID2 PRELI domain containing 2 0.0771615
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0695638
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0664317
PCBP2 poly(rC) binding protein 2 0.0659374
TRIO trio Rho guanine nucleotide exchange factor 0.0625193
RAD51B RAD51 paralog B 0.0615232
AHNAK AHNAK nucleoprotein 0.0607625
MEF2A myocyte enhancer factor 2A 0.0561787
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0553485
LOXL2 lysyl oxidase-like 2 0.054449
ELL2 elongation factor, RNA polymerase II, 2 0.0531947
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0522788
NRP1 neuropilin 1 0.0521936
FN1 fibronectin 1 0.052097
ANTXR2 anthrax toxin receptor 2 0.0518785
PDE4D phosphodiesterase 4D, cAMP-specific 0.0506089
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0502476
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0501317
MTSS1 metastasis suppressor 1 0.0498116
CDH13 cadherin 13 0.0487151
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0474072
ZEB2 zinc finger E-box binding homeobox 2 0.0466942
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0448369
DST dystonin 0.043667
RAI14 retinoic acid induced 14 0.0421158
CDCP1 CUB domain containing protein 1 0.0418947
SAMD9 sterile alpha motif domain containing 9 0.0410972
FLNB filamin B, beta 0.0404154
PSD3 pleckstrin and Sec7 domain containing 3 0.0396175
FAM20C family with sequence similarity 20, member C 0.0395995
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0394457
PTK2 protein tyrosine kinase 2 0.0394345
APP amyloid beta (A4) precursor protein 0.0383458
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0372732
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0372316
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.036988
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0369274
LRMDA leucine rich melanocyte differentiation associated 0.0369153
ESYT2 extended synaptotagmin-like protein 2 0.0365324
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0362768
CA12 carbonic anhydrase XII 0.0361869
PFKP phosphofructokinase, platelet 0.0361506
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0360616
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0360485
MACF1 microtubule-actin crosslinking factor 1 0.0351455
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0350122
EFNA5 ephrin-A5 0.0346354
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0344993
PIAS2 protein inhibitor of activated STAT, 2 0.0341253
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0337538
DLG1 discs, large homolog 1 (Drosophila) 0.0337326
ADD3 adducin 3 (gamma) 0.0336556
MYH9 myosin, heavy chain 9, non-muscle 0.0336497
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0336296
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0335164
AMPD3 adenosine monophosphate deaminase 3 0.0329316
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0325711
RUNX2 runt-related transcription factor 2 0.0320725
ANKRD36 ankyrin repeat domain 36 0.0315486
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0313503
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.030902
CEP250 centrosomal protein 250kDa 0.0305727
RARB retinoic acid receptor, beta 0.0299751
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0297993
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0293991
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0292869
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.029213
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0291853
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.029096
KDM7A lysine (K)-specific demethylase 7A 0.0290875
IFI44L interferon-induced protein 44-like 0.0290682
ZNF292 zinc finger protein 292 0.0290349
ZNF638 zinc finger protein 638 0.0290111
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0289405
ANGPTL4 angiopoietin-like 4 0.028802
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.028537
SNX9 sorting nexin 9 0.0284717
MAML3 mastermind-like 3 (Drosophila) 0.0282991
CCNY cyclin Y 0.0281341
JARID2 jumonji, AT rich interactive domain 2 0.0281009
AKAP13 A kinase (PRKA) anchor protein 13 0.0280661
ASPH aspartate beta-hydroxylase 0.0279059
PARD3 par-3 family cell polarity regulator 0.0278036
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0275692
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0274877
NPAS2 neuronal PAS domain protein 2 0.0269076
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0266921
LTBP1 latent transforming growth factor beta binding protein 1 0.0266848
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0262389

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157947
TMSB10 thymosin beta 10 -0.123087
GLCCI1 glucocorticoid induced 1 -0.0915658
VIM vimentin -0.0822349
GOLGA4 golgin A4 -0.0619277
FTL ferritin, light polypeptide -0.0598797
LOX lysyl oxidase -0.0592356
NTN4 netrin 4 -0.0518507
CD44 CD44 molecule (Indian blood group) -0.0505937
RAB1A RAB1A, member RAS oncogene family -0.0503095
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0498505
AADAC arylacetamide deacetylase -0.0484817
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0482069
SEC31A SEC31 homolog A (S. cerevisiae) -0.0478328
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0469312
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0465609
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0462864
COPA coatomer protein complex, subunit alpha -0.0457396
PTMA prothymosin, alpha -0.0455366
EGR1 early growth response 1 -0.0449524
DSCAM Down syndrome cell adhesion molecule -0.0443935
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0443127
ANKRD28 ankyrin repeat domain 28 -0.0442526
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0439811
RPS19 ribosomal protein S19 -0.0413052
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0405117
TNNC1 troponin C type 1 (slow) -0.0395805
RPL35A ribosomal protein L35a -0.0383514
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0382302
MT2A metallothionein 2A -0.0382021
RPLP1 ribosomal protein, large, P1 -0.0370573
VMP1 vacuole membrane protein 1 -0.0363489
RPL37A ribosomal protein L37a -0.0354221
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0342374
RPS8 ribosomal protein S8 -0.0341233
RPL23 ribosomal protein L23 -0.0335486
RPLP2 ribosomal protein, large, P2 -0.032918
EIF1 eukaryotic translation initiation factor 1 -0.0327501
NCOA7 nuclear receptor coactivator 7 -0.0318144
RPS6 ribosomal protein S6 -0.0312298
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0309907
NLK nemo-like kinase -0.0303569
CALU calumenin -0.0297379
TTC3 tetratricopeptide repeat domain 3 -0.0294291
ANKRD17 ankyrin repeat domain 17 -0.0291903
RPL31 ribosomal protein L31 -0.0289879
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0289425
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.028818
RPL34 ribosomal protein L34 -0.0281411
MORF4L2 mortality factor 4 like 2 -0.0280116
AKAP9 A kinase (PRKA) anchor protein 9 -0.0278037
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0278036
RPS29 ribosomal protein S29 -0.0274765
DDIT3 DNA-damage-inducible transcript 3 -0.0273821
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0273285
TPT1 tumor protein, translationally-controlled 1 -0.0268968
RPL32 ribosomal protein L32 -0.026246
RPS21 ribosomal protein S21 -0.0245227
HDLBP high density lipoprotein binding protein -0.0243652
KSR1 kinase suppressor of ras 1 -0.0241306
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0238281
GDI2 GDP dissociation inhibitor 2 -0.023635
TMEM263 transmembrane protein 263 -0.0234522
USP15 ubiquitin specific peptidase 15 -0.0234341
RPS3 ribosomal protein S3 -0.0229929
RPL36 ribosomal protein L36 -0.0228786
S100A6 S100 calcium binding protein A6 -0.0228326
BLZF1 basic leucine zipper nuclear factor 1 -0.0227534
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.0226919
KYNU kynureninase -0.0226418
RPS24 ribosomal protein S24 -0.022362
SLC38A2 solute carrier family 38, member 2 -0.022273
RPS13 ribosomal protein S13 -0.0222096
BPTF bromodomain PHD finger transcription factor -0.0219449
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0218066
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0216993
GLIPR1 GLI pathogenesis-related 1 -0.0216713
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0216347
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0215808
PTPRK protein tyrosine phosphatase, receptor type, K -0.0213053
RAB7A RAB7A, member RAS oncogene family -0.0212499
LOC102724023 ES1 protein homolog, mitochondrial -0.0210914
DENND4A DENN/MADD domain containing 4A -0.02095
SRP54 signal recognition particle 54kDa -0.0208081
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0205432
VRK2 vaccinia related kinase 2 -0.020539
PID1 phosphotyrosine interaction domain containing 1 -0.0203212
RPS16 ribosomal protein S16 -0.0195617
RPS12 ribosomal protein S12 -0.0195445
BASP1 brain abundant, membrane attached signal protein 1 -0.0194631
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0194524
MBD5 methyl-CpG binding domain protein 5 -0.0193459
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0191621
MON2 MON2 homolog (S. cerevisiae) -0.0188918
GOLGA3 golgin A3 -0.0188055
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0187214
IER3 immediate early response 3 -0.0187101
PMM2 phosphomannomutase 2 -0.0183244
GOLGB1 golgin B1 -0.0181199
YME1L1 YME1-like 1 ATPase -0.0180956