| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.168162 |
| ANKRD11 | ankyrin repeat domain 11 | 0.098006 |
| MCL1 | myeloid cell leukemia 1 | 0.082124 |
| FMNL2 | formin-like 2 | 0.0769095 |
| FLNB | filamin B, beta | 0.0745035 |
| TPM3 | tropomyosin 3 | 0.0691909 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0689024 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0684669 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0640512 |
| PCBP2 | poly(rC) binding protein 2 | 0.0636057 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0604671 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0592098 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0578964 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0557206 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0557089 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0500237 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0494955 |
| POTEF | POTE ankyrin domain family, member F | 0.048613 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.047171 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0467597 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0467238 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0457889 |
| MAP1B | microtubule-associated protein 1B | 0.0450785 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0449534 |
| RPL3 | ribosomal protein L3 | 0.0432596 |
| MSN | moesin | 0.0431537 |
| LAMC2 | laminin, gamma 2 | 0.0425901 |
| CCNY | cyclin Y | 0.0413529 |
| NDRG1 | N-myc downstream regulated 1 | 0.0404933 |
| ATXN1 | ataxin 1 | 0.0397472 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0391537 |
| PFKP | phosphofructokinase, platelet | 0.0390291 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0383885 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0380406 |
| KIAA0319 | KIAA0319 | 0.037869 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.037765 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0376801 |
| UPP1 | uridine phosphorylase 1 | 0.0376418 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0375936 |
| PLEC | plectin | 0.0373836 |
| KLC1 | kinesin light chain 1 | 0.037346 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0373323 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0372295 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0371355 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0367745 |
| PYGL | phosphorylase, glycogen, liver | 0.0362601 |
| STC2 | stanniocalcin 2 | 0.0358428 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.035003 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0346623 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0340716 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0337617 |
| BMP6 | bone morphogenetic protein 6 | 0.0336035 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.033577 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0331549 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0328711 |
| TJP1 | tight junction protein 1 | 0.0326439 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0323036 |
| OPTN | optineurin | 0.0318999 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0318889 |
| LAMA5 | laminin, alpha 5 | 0.0317592 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0316574 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0316403 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0315556 |
| AHNAK | AHNAK nucleoprotein | 0.0315497 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.03132 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0312882 |
| CTBP2 | C-terminal binding protein 2 | 0.0312478 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0310746 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0310098 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0308486 |
| GAN | gigaxonin | 0.0307258 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0305109 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0302944 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0300841 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0300109 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0299935 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0299204 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0298704 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0295719 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0294265 |
| CDCP1 | CUB domain containing protein 1 | 0.0292041 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0289649 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0289017 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.028834 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0286957 |
| NUMB | numb homolog (Drosophila) | 0.0286542 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0282527 |
| BRD2 | bromodomain containing 2 | 0.0278898 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0278772 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0277206 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0274967 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0266734 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0266157 |
| EGFR | epidermal growth factor receptor | 0.0259676 |
| INHBA | inhibin, beta A | 0.0259251 |
| KIF13A | kinesin family member 13A | 0.0258425 |
| EZR | ezrin | 0.0258154 |
| CUX1 | cut-like homeobox 1 | 0.0255563 |
| VEGFA | vascular endothelial growth factor A | 0.025478 |
| MAP4 | microtubule-associated protein 4 | 0.0252252 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.216842 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.121399 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.110618 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0996944 |
| BICC1 | BicC family RNA binding protein 1 | -0.0955626 |
| ACTG1 | actin gamma 1 | -0.0895907 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.080752 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0794418 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0782193 |
| PTMA | prothymosin, alpha | -0.0731219 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0673277 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0671155 |
| TMSB10 | thymosin beta 10 | -0.066981 |
| TXNRD1 | thioredoxin reductase 1 | -0.0657784 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0657312 |
| EFNA5 | ephrin-A5 | -0.0612632 |
| HDAC9 | histone deacetylase 9 | -0.060936 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0593696 |
| KYNU | kynureninase | -0.0588524 |
| NEGR1 | neuronal growth regulator 1 | -0.0552045 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0537801 |
| IGF2 | insulin-like growth factor 2 | -0.05335 |
| DENND4A | DENN/MADD domain containing 4A | -0.0507255 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0490094 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0481792 |
| OSMR | oncostatin M receptor | -0.0478533 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0473309 |
| RPL4 | ribosomal protein L4 | -0.0472069 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0450983 |
| EGR1 | early growth response 1 | -0.04452 |
| WDR43 | WD repeat domain 43 | -0.044328 |
| ASPH | aspartate beta-hydroxylase | -0.0435091 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0434237 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0431554 |
| ZNF804A | zinc finger protein 804A | -0.0426276 |
| AHR | aryl hydrocarbon receptor | -0.0422505 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0413348 |
| GRAMD1B | GRAM domain containing 1B | -0.0407789 |
| FGB | fibrinogen beta chain | -0.0406431 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0404848 |
| NTN4 | netrin 4 | -0.0387544 |
| BMP5 | bone morphogenetic protein 5 | -0.0376413 |
| VMP1 | vacuole membrane protein 1 | -0.0373732 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0366275 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0357393 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0344289 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0344287 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0341622 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0339523 |
| THBS1 | thrombospondin 1 | -0.0333698 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0331747 |
| LDHA | lactate dehydrogenase A | -0.033154 |
| CHN1 | chimerin 1 | -0.0326067 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0322102 |
| SVIL | supervillin | -0.0320245 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0311604 |
| NABP1 | nucleic acid binding protein 1 | -0.0311276 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0310087 |
| ECT2 | epithelial cell transforming 2 | -0.0308106 |
| UTRN | utrophin | -0.0306577 |
| VIM | vimentin | -0.0303148 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0301646 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0301596 |
| ERBIN | erbb2 interacting protein | -0.0301554 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0300784 |
| TPM4 | tropomyosin 4 | -0.0299139 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0298084 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.029694 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.029649 |
| RSPO3 | R-spondin 3 | -0.0292695 |
| IER3 | immediate early response 3 | -0.0292241 |
| RPL23 | ribosomal protein L23 | -0.0292109 |
| CAVIN1 | caveolae associated protein 1 | -0.0292002 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0290795 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0289398 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0285612 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0283563 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0280247 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0278659 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0274909 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0272641 |
| RHEB | Ras homolog enriched in brain | -0.0269369 |
| NOP58 | NOP58 ribonucleoprotein | -0.0268671 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0267466 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0264851 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0263938 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0262623 |
| AK1 | adenylate kinase 1 | -0.0262451 |
| GLIS3 | GLIS family zinc finger 3 | -0.026031 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0260023 |
| LAMB1 | laminin, beta 1 | -0.0257598 |
| SMAD2 | SMAD family member 2 | -0.0252681 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0250009 |
| CNKSR3 | CNKSR family member 3 | -0.0249838 |
| FGG | fibrinogen gamma chain | -0.0247806 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0247124 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0247013 |
| SRGN | serglycin | -0.0244984 |
| NFIA | nuclear factor I/A | -0.0244605 |
| TMEM123 | transmembrane protein 123 | -0.024178 |
