Neratinib (maleate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.169577
BACE2 beta-site APP-cleaving enzyme 2 0.154695
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.140142
NDRG1 N-myc downstream regulated 1 0.130333
LAMB3 laminin, beta 3 0.129641
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.117801
TXNRD1 thioredoxin reductase 1 0.100075
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0980563
SAMD4A sterile alpha motif domain containing 4A 0.0929012
AHNAK AHNAK nucleoprotein 0.091089
IGF2 insulin-like growth factor 2 0.0860546
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.081011
JMJD1C jumonji domain containing 1C 0.0789122
OGA O-GlcNAcase 0.0785659
KMT2C lysine (K)-specific methyltransferase 2C 0.0738467
CEMIP cell migration inducing protein, hyaluronan binding 0.0729793
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0710576
HLA-B major histocompatibility complex, class I, B 0.0704827
TMSB10 thymosin beta 10 0.0666593
FNDC3B fibronectin type III domain containing 3B 0.0662467
ENO1 enolase 1, (alpha) 0.065695
NAP1L1 nucleosome assembly protein 1-like 1 0.061524
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0593578
FOXP1 forkhead box P1 0.0589918
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0582212
PKM pyruvate kinase, muscle 0.0580943
GPHN gephyrin 0.0576363
TM4SF1 transmembrane 4 L six family member 1 0.0571854
VIM vimentin 0.0561926
DOCK5 dedicator of cytokinesis 5 0.0554268
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0554046
FBXL13 F-box and leucine-rich repeat protein 13 0.052727
NAMPT nicotinamide phosphoribosyltransferase 0.0523953
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0499381
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0496451
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0488315
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0487715
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0484987
BBX bobby sox homolog (Drosophila) 0.0481753
APP amyloid beta (A4) precursor protein 0.0479166
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0470122
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0461784
RPL11 ribosomal protein L11 0.0455386
B2M beta-2-microglobulin 0.0448884
UBE3C ubiquitin protein ligase E3C 0.0442717
SMYD3 SET and MYND domain containing 3 0.0442338
FAM13A family with sequence similarity 13, member A 0.0441604
TPM4 tropomyosin 4 0.0439667
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0434516
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0424099
SLTM SAFB-like, transcription modulator 0.0424032
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0422038
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0419553
RPS19 ribosomal protein S19 0.0414976
PCLO piccolo presynaptic cytomatrix protein 0.041447
ERRFI1 ERBB receptor feedback inhibitor 1 0.0404222
CANX calnexin 0.0402937
CTBP2 C-terminal binding protein 2 0.0402815
LIMCH1 LIM and calponin homology domains 1 0.0401548
FMN1 formin 1 0.0398009
SNX9 sorting nexin 9 0.0396724
DOCK1 dedicator of cytokinesis 1 0.0396218
IQGAP1 IQ motif containing GTPase activating protein 1 0.0389658
FLNB filamin B, beta 0.0388004
EIF1 eukaryotic translation initiation factor 1 0.03878
EXT1 exostosin glycosyltransferase 1 0.0387212
TRIO trio Rho guanine nucleotide exchange factor 0.0386643
MARCHF6 membrane associated ring-CH-type finger 6 0.0381676
KRT17 keratin 17, type I 0.0378779
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0377944
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0376918
CD44 CD44 molecule (Indian blood group) 0.037633
RB1CC1 RB1-inducible coiled-coil 1 0.0373348
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0372555
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.037138
RPL19 ribosomal protein L19 0.0366055
SEC31A SEC31 homolog A (S. cerevisiae) 0.0365448
YAP1 Yes-associated protein 1 0.0365331
ATXN1 ataxin 1 0.0364076
KTN1 kinectin 1 (kinesin receptor) 0.0363003
PTMA prothymosin, alpha 0.0355615
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0354859
CDCP1 CUB domain containing protein 1 0.0352329
EEF2 eukaryotic translation elongation factor 2 0.034759
PCBP2 poly(rC) binding protein 2 0.0343024
ASPH aspartate beta-hydroxylase 0.0340219
TP53BP2 tumor protein p53 binding protein 2 0.0335292
SH3D19 SH3 domain containing 19 0.0333314
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.03302
RBM25 RNA binding motif protein 25 0.0329879
RAB22A RAB22A, member RAS oncogene family 0.0326954
EHBP1 EH domain binding protein 1 0.0325571
VEGFA vascular endothelial growth factor A 0.0325309
ZNF638 zinc finger protein 638 0.0318288
FBXO34 F-box protein 34 0.0314216
GDI2 GDP dissociation inhibitor 2 0.0308454
UBE2K ubiquitin-conjugating enzyme E2K 0.0300559
NPEPPS aminopeptidase puromycin sensitive 0.0298091
TRIP12 thyroid hormone receptor interactor 12 0.0297294
DARS1 aspartyl-tRNA synthetase 1 0.0296636

decreased expression

Symbol Name Standardized Value
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.106345
MUC16 mucin 16, cell surface associated -0.0811167
VMP1 vacuole membrane protein 1 -0.0611261
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0608713
INTS6 integrator complex subunit 6 -0.0602297
NALF1 NALCN channel auxiliary factor 1 -0.0600526
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0591641
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0584654
DSCAM Down syndrome cell adhesion molecule -0.0576035
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0572815
PDE10A phosphodiesterase 10A -0.0570943
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0539619
MYO10 myosin X -0.0538523
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0535326
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0534451
TAOK3 TAO kinase 3 -0.052432
GRB10 growth factor receptor-bound protein 10 -0.0522364
ANXA2 annexin A2 -0.0521997
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0521601
NCOA3 nuclear receptor coactivator 3 -0.0520582
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0516793
KDM2A lysine (K)-specific demethylase 2A -0.0512128
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0497741
ZNF207 zinc finger protein 207 -0.0492831
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0491414
NIPBL Nipped-B homolog (Drosophila) -0.0489659
TGFA transforming growth factor, alpha -0.0482697
WAC WW domain containing adaptor with coiled-coil -0.0476334
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0472605
DGKD diacylglycerol kinase, delta 130kDa -0.0466328
PLSCR1 phospholipid scramblase 1 -0.0462539
RORA RAR-related orphan receptor A -0.0461209
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0449585
MAML2 mastermind-like 2 (Drosophila) -0.0446792
PARD3 par-3 family cell polarity regulator -0.0438685
OXSR1 oxidative stress responsive 1 -0.0433526
CCDC47 coiled-coil domain containing 47 -0.0433396
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.043063
ARF1 ADP-ribosylation factor 1 -0.042997
SETX senataxin -0.0429818
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0426255
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.042474
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0421796
MBD4 methyl-CpG binding domain protein 4 -0.0418589
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0414328
AFF1 AF4/FMR2 family, member 1 -0.0412655
TMEM41B transmembrane protein 41B -0.0412068
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0411094
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0396791
OSMR oncostatin M receptor -0.0395173
FOSL2 FOS-like antigen 2 -0.0390665
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0389626
ADAM10 ADAM metallopeptidase domain 10 -0.0388002
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0387126
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0385675
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0384077
LAMC2 laminin, gamma 2 -0.0384045
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0383925
SMOC1 SPARC related modular calcium binding 1 -0.0381812
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0378751
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0377953
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0375828
PIBF1 progesterone immunomodulatory binding factor 1 -0.0373526
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0373178
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0371661
DIAPH1 diaphanous-related formin 1 -0.0370624
DENND1A DENN/MADD domain containing 1A -0.0369637
TNRC18 trinucleotide repeat containing 18 -0.036577
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0364983
UFM1 ubiquitin-fold modifier 1 -0.0363767
LCORL ligand dependent nuclear receptor corepressor-like -0.0362126
AHI1 Abelson helper integration site 1 -0.03607
IFRD1 interferon-related developmental regulator 1 -0.0359712
TRA2A transformer 2 alpha homolog (Drosophila) -0.0358041
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0353697
WIPF2 WAS/WASL interacting protein family, member 2 -0.0349265
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0348145
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0342783
PIAS1 protein inhibitor of activated STAT, 1 -0.0339855
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.033969
SETD5 SET domain containing 5 -0.0338933
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0338759
SDC4 syndecan 4 -0.0336137
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.033503
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0331774
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0331494
ARHGAP5 Rho GTPase activating protein 5 -0.0328409
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.032798
ANKRD36C ankyrin repeat domain 36C -0.0327483
DST dystonin -0.0327066
FAM13B family with sequence similarity 13, member B -0.0325516
CCND1 cyclin D1 -0.0325248
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0323856
SAMD9 sterile alpha motif domain containing 9 -0.0323734
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0321215
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0320402
HMGA2 high mobility group AT-hook 2 -0.0317693
AFF4 AF4/FMR2 family, member 4 -0.031604
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0314584
SMAD2 SMAD family member 2 -0.0313539