| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.288713 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.169389 |
| TXNRD1 | thioredoxin reductase 1 | 0.120361 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.112129 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0970832 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.091209 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0815146 |
| TPM3 | tropomyosin 3 | 0.0800595 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0777506 |
| PCBP2 | poly(rC) binding protein 2 | 0.0761418 |
| RAD51B | RAD51 paralog B | 0.0737989 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0685883 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0618837 |
| WWOX | WW domain containing oxidoreductase | 0.0604512 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0586595 |
| FMNL2 | formin-like 2 | 0.0583729 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0576284 |
| XPOT | exportin, tRNA | 0.056379 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0548203 |
| PRELID2 | PRELI domain containing 2 | 0.054312 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0540256 |
| RPS18 | ribosomal protein S18 | 0.05089 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0483347 |
| ADAR | adenosine deaminase, RNA-specific | 0.0476173 |
| PFKP | phosphofructokinase, platelet | 0.0440208 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0437376 |
| SESN2 | sestrin 2 | 0.0434477 |
| RPL3 | ribosomal protein L3 | 0.0434399 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.042954 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0428872 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.042305 |
| CCND2 | cyclin D2 | 0.0422575 |
| SVIL | supervillin | 0.0415049 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0413275 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0398872 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0398762 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0397471 |
| PLEC | plectin | 0.0397387 |
| MCL1 | myeloid cell leukemia 1 | 0.0395593 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0388206 |
| MAP1B | microtubule-associated protein 1B | 0.0384535 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0380645 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.037189 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0367693 |
| CUX1 | cut-like homeobox 1 | 0.0367108 |
| PRKCE | protein kinase C, epsilon | 0.034879 |
| EXOC4 | exocyst complex component 4 | 0.0347869 |
| MAP4 | microtubule-associated protein 4 | 0.0345912 |
| LOXL2 | lysyl oxidase-like 2 | 0.0345119 |
| ANK2 | ankyrin 2, neuronal | 0.0344223 |
| RPS12 | ribosomal protein S12 | 0.034088 |
| DST | dystonin | 0.0339067 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0337173 |
| POTEF | POTE ankyrin domain family, member F | 0.0330205 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0328275 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0317253 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0315909 |
| DSPP | dentin sialophosphoprotein | 0.0314663 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0313674 |
| CDCP1 | CUB domain containing protein 1 | 0.0310735 |
| HMOX1 | heme oxygenase 1 | 0.0296262 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0295835 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.029133 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0288393 |
| TPI1 | triosephosphate isomerase 1 | 0.0285887 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0285551 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0284336 |
| DENR | density-regulated protein | 0.0282919 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0282637 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.028161 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0280048 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0274406 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0273527 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0272852 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0271281 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0265748 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0262099 |
| RPS3 | ribosomal protein S3 | 0.0260423 |
| JMJD1C | jumonji domain containing 1C | 0.0259604 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0259508 |
| APP | amyloid beta (A4) precursor protein | 0.0254576 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0254505 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0253664 |
| PYGL | phosphorylase, glycogen, liver | 0.0251848 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0250845 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0250775 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0249079 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0248768 |
| CTTN | cortactin | 0.0248123 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0247822 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0246026 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0245692 |
| KIF1A | kinesin family member 1A | 0.0244852 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.024483 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0244279 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.024178 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0241043 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0239703 |
| FLNA | filamin A, alpha | 0.0238303 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0235076 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.148355 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.131109 |
| PTMA | prothymosin, alpha | -0.0659683 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0521142 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0482722 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0471122 |
| TMSB10 | thymosin beta 10 | -0.0469426 |
| PDE10A | phosphodiesterase 10A | -0.0460926 |
| UBC | ubiquitin C | -0.0449985 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0421856 |
| HMGA2 | high mobility group AT-hook 2 | -0.0420017 |
| RPS27A | ribosomal protein S27a | -0.0411142 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0409917 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0405136 |
| VCL | vinculin | -0.0400358 |
| RRM2 | ribonucleotide reductase M2 | -0.0392789 |
| STC1 | stanniocalcin 1 | -0.0383082 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0371508 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0361256 |
| NABP1 | nucleic acid binding protein 1 | -0.0354322 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0334221 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.032838 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0309121 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0298799 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0294269 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0289837 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0279627 |
| RPL23 | ribosomal protein L23 | -0.0274543 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0264467 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.02642 |
| MKI67 | marker of proliferation Ki-67 | -0.0242268 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0237732 |
| IER3 | immediate early response 3 | -0.0231931 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0231162 |
| H1-0 | H1.0 linker histone | -0.023114 |
| IGF2 | insulin-like growth factor 2 | -0.0227886 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0223729 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.022141 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0220546 |
| RPS15 | ribosomal protein S15 | -0.0215686 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0215087 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0212125 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0197354 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0193995 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0193863 |
| RYR3 | ryanodine receptor 3 | -0.0193182 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0192352 |
| BMP5 | bone morphogenetic protein 5 | -0.0192093 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0191504 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0189975 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0189079 |
| SMAD3 | SMAD family member 3 | -0.0184292 |
| BPTF | bromodomain PHD finger transcription factor | -0.0183726 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0183648 |
| MYPN | myopalladin | -0.0182015 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0179775 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0179401 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0175524 |
| FTL | ferritin, light polypeptide | -0.0173458 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0172932 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0172622 |
| TPX2 | TPX2, microtubule-associated | -0.0168362 |
| ZNF217 | zinc finger protein 217 | -0.0168098 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0168091 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0168052 |
| ETV6 | ets variant 6 | -0.0164555 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0164138 |
| VMP1 | vacuole membrane protein 1 | -0.0163513 |
| EGR1 | early growth response 1 | -0.0162831 |
| DIAPH3 | diaphanous-related formin 3 | -0.0161962 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0161621 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0160794 |
| KIAA1328 | KIAA1328 | -0.0160393 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0156055 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0155133 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0154416 |
| ANLN | anillin, actin binding protein | -0.0153908 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0153634 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0153544 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0151904 |
| MYOF | myoferlin | -0.0151742 |
| EFNA5 | ephrin-A5 | -0.0150391 |
| TMPO | thymopoietin | -0.0145074 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0144351 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.014139 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.01409 |
| KNL1 | kinetochore scaffold 1 | -0.0139195 |
| BRD2 | bromodomain containing 2 | -0.0138705 |
| FAM199X | family with sequence similarity 199, X-linked | -0.0138251 |
| FMN1 | formin 1 | -0.0137969 |
| CCND1 | cyclin D1 | -0.0137162 |
| COL5A2 | collagen, type V, alpha 2 | -0.0136356 |
| THRAP3 | thyroid hormone receptor associated protein 3 | -0.0135832 |
| INTS6 | integrator complex subunit 6 | -0.0135715 |
| S100A10 | S100 calcium binding protein A10 | -0.0134963 |
| H3-3B | H3.3 histone B | -0.0134571 |
| RLF | rearranged L-myc fusion | -0.0134347 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0133258 |
| GOLGA4 | golgin A4 | -0.013207 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0131689 |
