Neratinib (maleate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.0851064
LMO7 LIM domain 7 0.0781002
TRIO trio Rho guanine nucleotide exchange factor 0.0688292
NPEPPS aminopeptidase puromycin sensitive 0.0669344
TSC22D2 TSC22 domain family, member 2 0.0651268
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0554827
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0486692
ITCH itchy E3 ubiquitin protein ligase 0.0461936
FAM13A family with sequence similarity 13, member A 0.0459546
KMT2E lysine (K)-specific methyltransferase 2E 0.0429028
RNF145 ring finger protein 145 0.0419305
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0401791
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0401623
KMT2C lysine (K)-specific methyltransferase 2C 0.0400132
ZFAND3 zinc finger, AN1-type domain 3 0.0399617
TOP1 topoisomerase (DNA) I 0.0394405
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0390381
ELL2 elongation factor, RNA polymerase II, 2 0.0386256
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0382789
RAB6A RAB6A, member RAS oncogene family 0.0376878
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0355443
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0348599
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0339278
LIMCH1 LIM and calponin homology domains 1 0.0333177
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0329685
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0328044
RPL35A ribosomal protein L35a 0.0321252
WDFY3 WD repeat and FYVE domain containing 3 0.0318091
EPS8 epidermal growth factor receptor pathway substrate 8 0.0314215
CTBP2 C-terminal binding protein 2 0.0314092
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0304775
STRN3 striatin, calmodulin binding protein 3 0.0304296
SETD5 SET domain containing 5 0.0303527
KDM3A lysine (K)-specific demethylase 3A 0.0300317
CD109 CD109 molecule 0.0295382
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0293683
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0292899
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0289857
FNDC3B fibronectin type III domain containing 3B 0.0289086
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0287799
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0285795
COPA coatomer protein complex, subunit alpha 0.0284342
CDK17 cyclin-dependent kinase 17 0.028152
EZR ezrin 0.0280889
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0279035
GPBP1 GC-rich promoter binding protein 1 0.0278255
PGK1 phosphoglycerate kinase 1 0.0275226
VEGFA vascular endothelial growth factor A 0.0274536
FCHO2 FCH domain only 2 0.0272898
UBE2H ubiquitin-conjugating enzyme E2H 0.027206
FNBP1L formin binding protein 1-like 0.0269524
PLEC plectin 0.0264843
TMEM123 transmembrane protein 123 0.02631
MYO6 myosin VI 0.0262976
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0261233
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0255875
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0251235
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0249643
CAVIN1 caveolae associated protein 1 0.0248359
ARHGAP29 Rho GTPase activating protein 29 0.0247496
TP53BP2 tumor protein p53 binding protein 2 0.0243309
WASF2 WAS protein family, member 2 0.0240853
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0235842
CCNY cyclin Y 0.0235537
CD2AP CD2-associated protein 0.0235165
ERRFI1 ERBB receptor feedback inhibitor 1 0.0232241
USP3 ubiquitin specific peptidase 3 0.0229802
MARCHF6 membrane associated ring-CH-type finger 6 0.0229795
FBXO11 F-box protein 11 0.0228447
PTK2 protein tyrosine kinase 2 0.0227942
RASAL2 RAS protein activator like 2 0.0224462
ENO2 enolase 2 (gamma, neuronal) 0.022357
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0217558
MACF1 microtubule-actin crosslinking factor 1 0.0216467
BCAR3 breast cancer anti-estrogen resistance 3 0.0216023
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0215693
JMJD1C jumonji domain containing 1C 0.021545
DHFR dihydrofolate reductase 0.0214788
LCORL ligand dependent nuclear receptor corepressor-like 0.0214649
CRABP2 cellular retinoic acid binding protein 2 0.0211318
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0210986
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0208971
RSRC2 arginine/serine-rich coiled-coil 2 0.0208521
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.020573
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0202999
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0202455
PPARG peroxisome proliferator-activated receptor gamma 0.0202258
RIOK3 RIO kinase 3 0.0201899
KPNB1 karyopherin (importin) beta 1 0.0200594
ERBIN erbb2 interacting protein 0.0199605
MCU mitochondrial calcium uniporter 0.0195048
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0194858
MXD1 MAX dimerization protein 1 0.0194311
ANKRD11 ankyrin repeat domain 11 0.0194193
NDFIP1 Nedd4 family interacting protein 1 0.0192768
HELZ helicase with zinc finger 0.0190996
AOPEP aminopeptidase O (putative) 0.0190586
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0189011
KDM5B lysine (K)-specific demethylase 5B 0.0188105
TMEM165 transmembrane protein 165 0.0188061

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.223165
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.175885
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.170149
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.151468
TMSB10 thymosin beta 10 -0.149748
FTL ferritin, light polypeptide -0.123095
NDRG1 N-myc downstream regulated 1 -0.12165
ASPH aspartate beta-hydroxylase -0.116102
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0978491
RPS27A ribosomal protein S27a -0.0950239
ENO1 enolase 1, (alpha) -0.0943927
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.089087
LAMC2 laminin, gamma 2 -0.0859482
RPL23 ribosomal protein L23 -0.0777116
RPS3 ribosomal protein S3 -0.0758949
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0713317
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0668536
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0631873
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0612116
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0601397
FBXO32 F-box protein 32 -0.0601379
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0598721
RACK1 receptor for activated C kinase 1 -0.0592594
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0586411
MT2A metallothionein 2A -0.0567308
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0560014
RPS19 ribosomal protein S19 -0.055146
SAMD4A sterile alpha motif domain containing 4A -0.0549306
LPP LIM domain containing preferred translocation partner in lipoma -0.0545108
TM4SF1 transmembrane 4 L six family member 1 -0.0530606
AHNAK AHNAK nucleoprotein -0.0527776
KRT7 keratin 7, type II -0.0524871
ACTG1 actin gamma 1 -0.051899
RPL9 ribosomal protein L9 -0.0514172
RPS12 ribosomal protein S12 -0.0507816
HMGB2 high mobility group box 2 -0.0467194
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0462102
G0S2 G0/G1 switch 2 -0.0461234
RPL37A ribosomal protein L37a -0.0458517
PDIA4 protein disulfide isomerase family A, member 4 -0.0452476
IFI16 interferon, gamma-inducible protein 16 -0.0435124
RPL8 ribosomal protein L8 -0.0428221
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0425274
CD44 CD44 molecule (Indian blood group) -0.0422234
LAMB3 laminin, beta 3 -0.0417192
NAV2 neuron navigator 2 -0.0415867
RPS8 ribosomal protein S8 -0.0413344
S100A6 S100 calcium binding protein A6 -0.0413317
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0405267
CALR calreticulin -0.0398777
POTEF POTE ankyrin domain family, member F -0.0396138
SQSTM1 sequestosome 1 -0.0382422
RPLP2 ribosomal protein, large, P2 -0.0377285
SDC4 syndecan 4 -0.0375796
RPL12 ribosomal protein L12 -0.0364567
NAP1L1 nucleosome assembly protein 1-like 1 -0.0363471
IFI27 interferon, alpha-inducible protein 27 -0.0358559
PTMA prothymosin, alpha -0.035723
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0353803
RPL5 ribosomal protein L5 -0.0347414
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0339153
RPS17 ribosomal protein S17 -0.0337883
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0337819
RPL18 ribosomal protein L18 -0.0333954
MYH9 myosin, heavy chain 9, non-muscle -0.0330009
EEF2 eukaryotic translation elongation factor 2 -0.0329107
FLNA filamin A, alpha -0.0318524
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0316904
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0315946
RIGI RNA sensor RIG-I -0.0313366
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0312057
GPX4 glutathione peroxidase 4 -0.031151
RPL32 ribosomal protein L32 -0.0309908
RPL30 ribosomal protein L30 -0.0303709
LOC112694756 uncharaterized LOC112694756 -0.0302195
RPL19 ribosomal protein L19 -0.0301865
EEF1G eukaryotic translation elongation factor 1 gamma -0.030025
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0299751
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0299027
RPLP1 ribosomal protein, large, P1 -0.0298932
JUN jun proto-oncogene -0.0294669
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0293524
PLSCR1 phospholipid scramblase 1 -0.0291416
RPL11 ribosomal protein L11 -0.0289651
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0287531
RPL36 ribosomal protein L36 -0.0281065
PCBP2 poly(rC) binding protein 2 -0.0280193
MX1 MX dynamin-like GTPase 1 -0.0277145
RPL7 ribosomal protein L7 -0.0277126
TMSB4X thymosin beta 4, X-linked -0.0274092
SMC4 structural maintenance of chromosomes 4 -0.0269794
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0269572
RPS5 ribosomal protein S5 -0.0267342
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0264296
HMGA1 high mobility group AT-hook 1 -0.0263212
CCSER1 coiled-coil serine-rich protein 1 -0.0261031
CBX3 chromobox homolog 3 -0.0260325
LDHA lactate dehydrogenase A -0.0252693
EPCAM epithelial cell adhesion molecule -0.0252663
SKP1 S-phase kinase-associated protein 1 -0.024886