| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.184234 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.176498 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.170424 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0942735 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0915834 |
| ASPH | aspartate beta-hydroxylase | 0.0797574 |
| TXNRD1 | thioredoxin reductase 1 | 0.0777539 |
| MCL1 | myeloid cell leukemia 1 | 0.0695313 |
| PDE10A | phosphodiesterase 10A | 0.0639142 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0616093 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0606804 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0598869 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0596044 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0573171 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0558336 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.054216 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.053119 |
| RAD51B | RAD51 paralog B | 0.0512996 |
| AUTS2 | autism susceptibility candidate 2 | 0.0498379 |
| PYGL | phosphorylase, glycogen, liver | 0.0494789 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0492791 |
| MAP7 | microtubule-associated protein 7 | 0.0489228 |
| FLNB | filamin B, beta | 0.0466151 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0431998 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0416043 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0393936 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0379392 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0358365 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0356055 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0354242 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0347905 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0340819 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.032511 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0322734 |
| AHNAK | AHNAK nucleoprotein | 0.0322679 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0320228 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0319565 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0316291 |
| MFF | mitochondrial fission factor | 0.0312045 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0308084 |
| PCBP2 | poly(rC) binding protein 2 | 0.0307118 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0303926 |
| PRELID2 | PRELI domain containing 2 | 0.0303903 |
| CTSL | cathepsin L | 0.0291916 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0290415 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0285701 |
| TBXT | T-box transcription factor T | 0.0281727 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0281137 |
| CD109 | CD109 molecule | 0.0278916 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0273911 |
| OXSR1 | oxidative stress responsive 1 | 0.0272967 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.027233 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0269985 |
| SVIL | supervillin | 0.0260862 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.025819 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0255034 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0254547 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0252346 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0244735 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0244724 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.024239 |
| EZR | ezrin | 0.0238155 |
| CANX | calnexin | 0.023655 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0234559 |
| MSN | moesin | 0.0232678 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0229251 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0221569 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0218967 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0218293 |
| PCED1B | PC-esterase domain containing 1B | 0.0218246 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0218241 |
| CTBP2 | C-terminal binding protein 2 | 0.0217899 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0213305 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0211614 |
| TUSC3 | tumor suppressor candidate 3 | 0.0210939 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.021065 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0210078 |
| EXOC4 | exocyst complex component 4 | 0.0209379 |
| PGK1 | phosphoglycerate kinase 1 | 0.0203112 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0200323 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0199792 |
| PFKP | phosphofructokinase, platelet | 0.0198551 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0193298 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0191461 |
| INHBA | inhibin, beta A | 0.019068 |
| ANTXR1 | anthrax toxin receptor 1 | 0.018586 |
| EXOC6B | exocyst complex component 6B | 0.0185396 |
| PKM | pyruvate kinase, muscle | 0.0185099 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.01848 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0184737 |
| EFNA5 | ephrin-A5 | 0.0184347 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0183957 |
| IL6 | interleukin 6 | 0.0182078 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0181797 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0180731 |
| SEPTIN10 | septin 10 | 0.0176902 |
| MKI67 | marker of proliferation Ki-67 | 0.0176211 |
| TLK1 | tousled-like kinase 1 | 0.0176118 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0175255 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0173905 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | -0.0978896 |
| TMSB10 | thymosin beta 10 | -0.0956818 |
| RPS12 | ribosomal protein S12 | -0.0758107 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0757263 |
| RPL26 | ribosomal protein L26 | -0.0716163 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0704562 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0702791 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0668081 |
| RPL37A | ribosomal protein L37a | -0.0663625 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0626211 |
| RPL9 | ribosomal protein L9 | -0.0580416 |
| RPS3 | ribosomal protein S3 | -0.0575193 |
| COL5A2 | collagen, type V, alpha 2 | -0.0573094 |
| PTMA | prothymosin, alpha | -0.0539361 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0537141 |
| VCL | vinculin | -0.0522601 |
| DST | dystonin | -0.0519174 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0501165 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0500846 |
| RPL23 | ribosomal protein L23 | -0.0435754 |
| VIM | vimentin | -0.0410327 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0384975 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0374138 |
| RPS27A | ribosomal protein S27a | -0.0365252 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0362793 |
| RPS17 | ribosomal protein S17 | -0.0358665 |
| RPS8 | ribosomal protein S8 | -0.0354565 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0342221 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0334525 |
| RPL31 | ribosomal protein L31 | -0.0330314 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0327551 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0326922 |
| KYNU | kynureninase | -0.0323558 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0322483 |
| RPS19 | ribosomal protein S19 | -0.0317572 |
| RPL12 | ribosomal protein L12 | -0.0316164 |
| RPL11 | ribosomal protein L11 | -0.0312063 |
| RPL37 | ribosomal protein L37 | -0.0311708 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0308094 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0295868 |
| RPS21 | ribosomal protein S21 | -0.028507 |
| RPS4X | ribosomal protein S4, X-linked | -0.0284816 |
| RPS24 | ribosomal protein S24 | -0.0283195 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0274778 |
| RPL34 | ribosomal protein L34 | -0.0271664 |
| RPL36 | ribosomal protein L36 | -0.0256353 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0253786 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0249331 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0247338 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0245241 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0244616 |
| RTN1 | reticulon 1 | -0.0242837 |
| KIAA0825 | KIAA0825 | -0.0239145 |
| HLA-B | major histocompatibility complex, class I, B | -0.023684 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0234888 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0234713 |
| FN1 | fibronectin 1 | -0.0234398 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0232131 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0230662 |
| CTSC | cathepsin C | -0.0229584 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0228275 |
| RPL5 | ribosomal protein L5 | -0.0225153 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0223982 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0219551 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0219287 |
| RPL18 | ribosomal protein L18 | -0.0217353 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0216589 |
| RPL13A | ribosomal protein L13a | -0.0216256 |
| RPS5 | ribosomal protein S5 | -0.0212868 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0211539 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0211219 |
| RPS27 | ribosomal protein S27 | -0.0210177 |
| RPS14 | ribosomal protein S14 | -0.0207395 |
| RPL35 | ribosomal protein L35 | -0.0207202 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0206122 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0204198 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.020411 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0199821 |
| PTEN | phosphatase and tensin homolog | -0.0194983 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.019492 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0192484 |
| GLCCI1 | glucocorticoid induced 1 | -0.0191564 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0190069 |
| NRCAM | neuronal cell adhesion molecule | -0.018789 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0187255 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0183451 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0183145 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0183031 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0182693 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.018264 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0181764 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.018139 |
| ATF4 | activating transcription factor 4 | -0.0180672 |
| LSAMP | limbic system-associated membrane protein | -0.0180462 |
| RACK1 | receptor for activated C kinase 1 | -0.0180077 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0179306 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0178854 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0178389 |
| WDR43 | WD repeat domain 43 | -0.0176963 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0175863 |
