| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | 0.182938 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.181539 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.148415 |
| VIM | vimentin | 0.116921 |
| COL6A3 | collagen, type VI, alpha 3 | 0.114823 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.112405 |
| AFF4 | AF4/FMR2 family, member 4 | 0.109732 |
| JMJD1C | jumonji domain containing 1C | 0.097497 |
| FN1 | fibronectin 1 | 0.0971886 |
| APP | amyloid beta (A4) precursor protein | 0.0966413 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0953159 |
| MYO10 | myosin X | 0.092671 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.092039 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.086637 |
| MYO1E | myosin IE | 0.0857059 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0830063 |
| PGK1 | phosphoglycerate kinase 1 | 0.0826413 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0807292 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0785086 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0782188 |
| GNAS | GNAS complex locus | 0.0747741 |
| ENO1 | enolase 1, (alpha) | 0.0747177 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.068364 |
| NF1 | neurofibromin 1 | 0.0677043 |
| RPL23 | ribosomal protein L23 | 0.0666349 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0631111 |
| PTK2 | protein tyrosine kinase 2 | 0.0610951 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0588743 |
| RPL26 | ribosomal protein L26 | 0.0579921 |
| VMP1 | vacuole membrane protein 1 | 0.0579751 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0557534 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0542559 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.054183 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0537786 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0510849 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0510698 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0503753 |
| OXR1 | oxidation resistance 1 | 0.0496005 |
| LDHA | lactate dehydrogenase A | 0.0464342 |
| SRPK2 | SRSF protein kinase 2 | 0.0462058 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0430247 |
| FAT1 | FAT atypical cadherin 1 | 0.0425783 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0416067 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.04103 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0407905 |
| GOLGA4 | golgin A4 | 0.0391322 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0377415 |
| MCL1 | myeloid cell leukemia 1 | 0.0362619 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0352553 |
| TMSB10 | thymosin beta 10 | 0.0347658 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0344413 |
| RPS27A | ribosomal protein S27a | 0.0324003 |
| DST | dystonin | 0.0277734 |
| CTBP2 | C-terminal binding protein 2 | 0.0274602 |
| RORA | RAR-related orphan receptor A | 0.0272271 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0266195 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0249042 |
| PRELID2 | PRELI domain containing 2 | 0.0247423 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0243994 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0238438 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0234122 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0229904 |
| ASPH | aspartate beta-hydroxylase | 0.0227884 |
| GRB10 | growth factor receptor-bound protein 10 | 0.022416 |
| AHNAK | AHNAK nucleoprotein | 0.0221583 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0220535 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0208175 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0204322 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0199174 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0198856 |
| IGF2 | insulin-like growth factor 2 | 0.0198287 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0197582 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0184028 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0183575 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0176817 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0176088 |
| RPL37A | ribosomal protein L37a | 0.0174373 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0157238 |
| GPC6 | glypican 6 | 0.0146076 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0141247 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0139898 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0139463 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0131995 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0131391 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0128428 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0124354 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0116385 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.00932282 |
| ANXA2 | annexin A2 | 0.00852723 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.00844154 |
| RAD51B | RAD51 paralog B | 0.00836844 |
| MT2A | metallothionein 2A | 0.00763731 |
| RPS8 | ribosomal protein S8 | 0.00702808 |
| CD44 | CD44 molecule (Indian blood group) | 0.0070108 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.00669562 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.00611684 |
| B2M | beta-2-microglobulin | 0.00573946 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00560316 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.00543375 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.00534756 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.094074 |
| LMO7 | LIM domain 7 | -0.0923341 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0773961 |
| PDE10A | phosphodiesterase 10A | -0.0750231 |
| EHBP1 | EH domain binding protein 1 | -0.0701151 |
| SNX9 | sorting nexin 9 | -0.0691134 |
| PARD3 | par-3 family cell polarity regulator | -0.0667822 |
| SBF2 | SET binding factor 2 | -0.0657253 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0651297 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0649847 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0649017 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0629883 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0626664 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0586188 |
| POTEF | POTE ankyrin domain family, member F | -0.0577844 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0552516 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0530463 |
| RASA3 | RAS p21 protein activator 3 | -0.0529948 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.051659 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0510613 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0508549 |
| EGFR | epidermal growth factor receptor | -0.0507601 |
| RPL37 | ribosomal protein L37 | -0.050597 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.049124 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0491143 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0487738 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0484544 |
| TBC1D22A | TBC1 domain family, member 22A | -0.048087 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0461917 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0461015 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0438245 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0437874 |
| TENM3 | teneurin transmembrane protein 3 | -0.0434208 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0430708 |
| STAG2 | stromal antigen 2 | -0.0422212 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0421658 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0411156 |
| RPLP2 | ribosomal protein, large, P2 | -0.0410645 |
| COPA | coatomer protein complex, subunit alpha | -0.0409261 |
| SPAG9 | sperm associated antigen 9 | -0.0407163 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0401891 |
| FRMD4A | FERM domain containing 4A | -0.0386823 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0385684 |
| RPS16 | ribosomal protein S16 | -0.0372013 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0364435 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0363353 |
| SPATA13 | spermatogenesis associated 13 | -0.036182 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0353486 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0345106 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0343326 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0340674 |
| ZNF292 | zinc finger protein 292 | -0.0335113 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0332194 |
| PTMA | prothymosin, alpha | -0.0327733 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.032515 |
| FAM13A | family with sequence similarity 13, member A | -0.0325129 |
| FMNL2 | formin-like 2 | -0.0319824 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0319226 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0314605 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0312718 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0310037 |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | -0.0306254 |
| ITGA6 | integrin, alpha 6 | -0.0305255 |
| LAMB3 | laminin, beta 3 | -0.0296671 |
| VCL | vinculin | -0.0296521 |
| RUNX1 | runt-related transcription factor 1 | -0.0277989 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0275174 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0274954 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0274648 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0269381 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0268222 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0266504 |
| NDRG1 | N-myc downstream regulated 1 | -0.0264179 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.026328 |
| RAB10 | RAB10, member RAS oncogene family | -0.0261162 |
| MEF2A | myocyte enhancer factor 2A | -0.0259709 |
| MYOF | myoferlin | -0.025198 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.02481 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.024679 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0246144 |
| EGR1 | early growth response 1 | -0.0244443 |
| OGA | O-GlcNAcase | -0.023557 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0232088 |
| RACK1 | receptor for activated C kinase 1 | -0.0231287 |
| RPS6 | ribosomal protein S6 | -0.0229428 |
| NFIA | nuclear factor I/A | -0.0217972 |
| SMAD3 | SMAD family member 3 | -0.0217143 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0213688 |
| CDK6 | cyclin-dependent kinase 6 | -0.0206358 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0199335 |
| UBE2Z | ubiquitin-conjugating enzyme E2Z | -0.019653 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0193077 |
| S100A10 | S100 calcium binding protein A10 | -0.0190547 |
| EZR | ezrin | -0.0178696 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0173759 |
| RPL12 | ribosomal protein L12 | -0.016218 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0157264 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0141699 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0141367 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0133438 |
