| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.13943 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.128968 |
| COL11A1 | collagen, type XI, alpha 1 | 0.125598 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.118984 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.11196 |
| PCDH9 | protocadherin 9 | 0.0961182 |
| CADM2 | cell adhesion molecule 2 | 0.0812064 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0708254 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0704122 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0663719 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0642783 |
| DST | dystonin | 0.0640686 |
| COL3A1 | collagen, type III, alpha 1 | 0.0557792 |
| COL5A2 | collagen, type V, alpha 2 | 0.0540985 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0531744 |
| LRRC4C | leucine rich repeat containing 4C | 0.0530514 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0506644 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0503523 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0460532 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0440093 |
| RAD51B | RAD51 paralog B | 0.0437917 |
| NTM | neurotrimin | 0.0427956 |
| NEBL | nebulette | 0.0416625 |
| SNX6 | sorting nexin 6 | 0.0413683 |
| APP | amyloid beta (A4) precursor protein | 0.0412492 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0406643 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0395882 |
| BPTF | bromodomain PHD finger transcription factor | 0.0385629 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0384166 |
| ANK2 | ankyrin 2, neuronal | 0.0378736 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0374306 |
| PRKD1 | protein kinase D1 | 0.037221 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0370614 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0364766 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0362294 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0359425 |
| SMYD3 | SET and MYND domain containing 3 | 0.0359328 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0356414 |
| H1-0 | H1.0 linker histone | 0.0353438 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.035157 |
| UTRN | utrophin | 0.0350869 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0349236 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0349149 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0346985 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0344557 |
| PRTG | protogenin | 0.034436 |
| RASAL2 | RAS protein activator like 2 | 0.0341338 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0341049 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0336873 |
| MKI67 | marker of proliferation Ki-67 | 0.0336098 |
| MPG | N-methylpurine-DNA glycosylase | 0.0327676 |
| SLC44A5 | solute carrier family 44, member 5 | 0.0326556 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.032464 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0324426 |
| TOX | thymocyte selection-associated high mobility group box | 0.0323398 |
| TRIM2 | tripartite motif containing 2 | 0.0323118 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0317465 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0315781 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0315277 |
| MAP4 | microtubule-associated protein 4 | 0.0313562 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0311687 |
| RAB31 | RAB31, member RAS oncogene family | 0.0307147 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0302415 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.030153 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0300599 |
| METAP2 | methionyl aminopeptidase 2 | 0.0299053 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0299009 |
| THOC2 | THO complex 2 | 0.0290312 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0287828 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0287504 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0284669 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0283733 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0283436 |
| TENM2 | teneurin transmembrane protein 2 | 0.0282568 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.02823 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0279792 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0273058 |
| TENM3 | teneurin transmembrane protein 3 | 0.0272223 |
| MTDH | metadherin | 0.0270862 |
| ATXN2 | ataxin 2 | 0.0270222 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0270046 |
| TCF12 | transcription factor 12 | 0.0267415 |
| NFIA | nuclear factor I/A | 0.0264071 |
| TJP1 | tight junction protein 1 | 0.0263242 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0263128 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0253231 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.025147 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0250988 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.024972 |
| NHSL1 | NHS-like 1 | 0.0248659 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0248167 |
| WASF2 | WAS protein family, member 2 | 0.0247793 |
| MEIS2 | Meis homeobox 2 | 0.0245298 |
| GNAS | GNAS complex locus | 0.0243645 |
| GOLGA4 | golgin A4 | 0.0243438 |
| CLIC4 | chloride intracellular channel 4 | 0.0240096 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0238638 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0234665 |
| SSH2 | slingshot protein phosphatase 2 | 0.0234265 |
| VCL | vinculin | 0.0233553 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF292 | zinc finger protein 292 | -0.0906489 |
| SPAG9 | sperm associated antigen 9 | -0.073553 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.053047 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0525351 |
| HDAC9 | histone deacetylase 9 | -0.0511762 |
| RPL5 | ribosomal protein L5 | -0.0447249 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0402944 |
| TMSB10 | thymosin beta 10 | -0.038774 |
| RPL7 | ribosomal protein L7 | -0.0363738 |
| RPS27A | ribosomal protein S27a | -0.035877 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0350455 |
| RPL23 | ribosomal protein L23 | -0.0342636 |
| PEG10 | paternally expressed 10 | -0.0334892 |
| MTF2 | metal response element binding transcription factor 2 | -0.0330645 |
| RPS16 | ribosomal protein S16 | -0.032687 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0320298 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0317904 |
| MB21D2 | Mab-21 domain containing 2 | -0.0317114 |
| QKI | QKI, KH domain containing, RNA binding | -0.031529 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.031269 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0311286 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0310244 |
| WDR43 | WD repeat domain 43 | -0.0306797 |
| SYT1 | synaptotagmin I | -0.0303911 |
| MYO10 | myosin X | -0.0303272 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0302911 |
| RPL35A | ribosomal protein L35a | -0.029669 |
| ZNF608 | zinc finger protein 608 | -0.029614 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.0294523 |
| RPL26 | ribosomal protein L26 | -0.0293487 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0290949 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0289768 |
| RPS13 | ribosomal protein S13 | -0.0281317 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0279101 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0278824 |
| CBX3 | chromobox homolog 3 | -0.0275345 |
| RBM39 | RNA binding motif protein 39 | -0.0273581 |
| ATG5 | autophagy related 5 | -0.0266742 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0263499 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0263425 |
| VMP1 | vacuole membrane protein 1 | -0.0258123 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0257767 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0254621 |
| RASA2 | RAS p21 protein activator 2 | -0.0252202 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0251828 |
| SRP54 | signal recognition particle 54kDa | -0.0246454 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0246224 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0241281 |
| DSTN | destrin (actin depolymerizing factor) | -0.0238052 |
| TMEM64 | transmembrane protein 64 | -0.0236552 |
| RPL37 | ribosomal protein L37 | -0.0234918 |
| RPL37A | ribosomal protein L37a | -0.0234404 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | -0.0234108 |
| USP3 | ubiquitin specific peptidase 3 | -0.0231149 |
| MED13L | mediator complex subunit 13-like | -0.022625 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0226219 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0224486 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0223616 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.0223093 |
| JMJD1C | jumonji domain containing 1C | -0.0220837 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0218462 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0217757 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0215541 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | -0.021487 |
| RIOK3 | RIO kinase 3 | -0.0213231 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0210768 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0210538 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0209004 |
| PDGFC | platelet derived growth factor C | -0.020876 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0206787 |
| NBAS | neuroblastoma amplified sequence | -0.0206742 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0205496 |
| ABI1 | abl-interactor 1 | -0.0201102 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0199995 |
| FBXO11 | F-box protein 11 | -0.019605 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0194783 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0194774 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0194561 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.01933 |
| RPRD1B | regulation of nuclear pre-mRNA domain containing 1B | -0.0190611 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0190317 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0189189 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0188784 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.0188357 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0187917 |
| COX6C | cytochrome c oxidase subunit VIc | -0.0186546 |
| RLIM | ring finger protein, LIM domain interacting | -0.0184854 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0183353 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0183171 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.0182055 |
| USP36 | ubiquitin specific peptidase 36 | -0.0181432 |
| POMP | proteasome maturation protein | -0.0177678 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0176849 |
| ORC4 | origin recognition complex, subunit 4 | -0.0176036 |
| NUP54 | nucleoporin 54kDa | -0.0175008 |
| USP34 | ubiquitin specific peptidase 34 | -0.0174796 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.017443 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.017359 |
| KLF10 | Kruppel-like factor 10 | -0.0173269 |
| ARF4 | ADP-ribosylation factor 4 | -0.0172687 |
