| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.177726 |
| MUC4 | mucin 4, cell surface associated | 0.111298 |
| FN1 | fibronectin 1 | 0.0911671 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0786859 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0785777 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0785334 |
| SVIL | supervillin | 0.0783343 |
| RNF213 | ring finger protein 213 | 0.0665317 |
| SYT14 | synaptotagmin XIV | 0.0614648 |
| MYO1E | myosin IE | 0.0610881 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0607794 |
| POTEF | POTE ankyrin domain family, member F | 0.0576875 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0570202 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.056339 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0559347 |
| PCBP2 | poly(rC) binding protein 2 | 0.0546052 |
| DSPP | dentin sialophosphoprotein | 0.0541449 |
| FMNL2 | formin-like 2 | 0.0523535 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0516497 |
| EGFR | epidermal growth factor receptor | 0.0493739 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0488933 |
| AHNAK | AHNAK nucleoprotein | 0.04817 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0463811 |
| MUC16 | mucin 16, cell surface associated | 0.0461149 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0451384 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0448831 |
| VEGFA | vascular endothelial growth factor A | 0.0436069 |
| ACTG1 | actin gamma 1 | 0.0422678 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0422171 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0421859 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.042071 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0417875 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0396317 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0394133 |
| MX1 | MX dynamin-like GTPase 1 | 0.0393556 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0388162 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0385804 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0382485 |
| DAPK1 | death-associated protein kinase 1 | 0.038089 |
| DSG2 | desmoglein 2 | 0.0380219 |
| GOLGB1 | golgin B1 | 0.0373472 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0372968 |
| STC2 | stanniocalcin 2 | 0.0368472 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0367399 |
| TJP1 | tight junction protein 1 | 0.0365759 |
| TPM4 | tropomyosin 4 | 0.0365397 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0365345 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0360566 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0352723 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0348659 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0346947 |
| MYO5B | myosin VB | 0.0346253 |
| KRT19 | keratin 19, type I | 0.0343838 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.034379 |
| HMGA1 | high mobility group AT-hook 1 | 0.0340088 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0337917 |
| MEF2A | myocyte enhancer factor 2A | 0.0336573 |
| LIPH | lipase, member H | 0.0336527 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0334972 |
| JUP | junction plakoglobin | 0.0333359 |
| PLSCR1 | phospholipid scramblase 1 | 0.0328625 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0324648 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0323282 |
| RPS18 | ribosomal protein S18 | 0.0318995 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.0313597 |
| ASS1 | argininosuccinate synthase 1 | 0.0309471 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0309091 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0302878 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0302739 |
| MX2 | MX dynamin-like GTPase 2 | 0.0302331 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0302017 |
| CLDN4 | claudin 4 | 0.0300711 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.029797 |
| SNX9 | sorting nexin 9 | 0.0293072 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0291686 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0286916 |
| CLDN1 | claudin 1 | 0.0285335 |
| HDAC9 | histone deacetylase 9 | 0.0284712 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0283987 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0282405 |
| BRD4 | bromodomain containing 4 | 0.0282257 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0281804 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0273132 |
| IFI44L | interferon-induced protein 44-like | 0.0272633 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0271072 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0268438 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0267189 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0266693 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0263755 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0262551 |
| ERBIN | erbb2 interacting protein | 0.02621 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0260157 |
| FTL | ferritin, light polypeptide | 0.0258728 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0258628 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0254993 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0253108 |
| CNKSR3 | CNKSR family member 3 | 0.0250227 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0248445 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0246345 |
| SULF2 | sulfatase 2 | 0.0245828 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.298437 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102847 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0931279 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0898246 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0894718 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0807657 |
| PTMA | prothymosin, alpha | -0.0776608 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0678707 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.067278 |
| TSC22D2 | TSC22 domain family, member 2 | -0.064412 |
| FAM3C | family with sequence similarity 3, member C | -0.0643985 |
| LAMB3 | laminin, beta 3 | -0.063255 |
| RPS24 | ribosomal protein S24 | -0.0582091 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0563489 |
| RPL35A | ribosomal protein L35a | -0.0562639 |
| DIAPH3 | diaphanous-related formin 3 | -0.0534609 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.053035 |
| ECT2 | epithelial cell transforming 2 | -0.0504251 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0503847 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0491862 |
| RPL23 | ribosomal protein L23 | -0.0486812 |
| RTN4 | reticulon 4 | -0.0463126 |
| RPLP1 | ribosomal protein, large, P1 | -0.0454378 |
| SDC4 | syndecan 4 | -0.0453297 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0453038 |
| KRT8 | keratin 8, type II | -0.043259 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0424497 |
| TMSB10 | thymosin beta 10 | -0.0424052 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0420604 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0418314 |
| SPAG9 | sperm associated antigen 9 | -0.0411641 |
| ANXA2 | annexin A2 | -0.0409388 |
| OGA | O-GlcNAcase | -0.0406866 |
| ANLN | anillin, actin binding protein | -0.040484 |
| HMGB2 | high mobility group box 2 | -0.0397978 |
| RPS21 | ribosomal protein S21 | -0.0396959 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0389342 |
| TOP1 | topoisomerase (DNA) I | -0.0387667 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0387233 |
| MKI67 | marker of proliferation Ki-67 | -0.0383312 |
| RPS19 | ribosomal protein S19 | -0.0374775 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0371503 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0371201 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0357351 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0356657 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.035587 |
| RLF | rearranged L-myc fusion | -0.0351387 |
| RPL11 | ribosomal protein L11 | -0.0341644 |
| RBM39 | RNA binding motif protein 39 | -0.0340927 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0324929 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0324428 |
| TFRC | transferrin receptor | -0.0324382 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | -0.032003 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0316551 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0314291 |
| GOLGA4 | golgin A4 | -0.0312582 |
| FOSL1 | FOS-like antigen 1 | -0.0311701 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0310303 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0307518 |
| RAD21 | RAD21 homolog (S. pombe) | -0.030513 |
| NAV2 | neuron navigator 2 | -0.029882 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0296647 |
| CENPF | centromere protein F, 350/400kDa | -0.029647 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0295456 |
| IL6ST | interleukin 6 signal transducer | -0.0290758 |
| VCL | vinculin | -0.0290056 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0286351 |
| CEP95 | centrosomal protein 95kDa | -0.0286281 |
| FRMD5 | FERM domain containing 5 | -0.0284221 |
| THBS1 | thrombospondin 1 | -0.0282592 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0277669 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0274818 |
| RPL34 | ribosomal protein L34 | -0.0274791 |
| TFG | TRK-fused gene | -0.0274054 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0274047 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0273574 |
| GPHN | gephyrin | -0.0272515 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0268565 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0268217 |
| RPS15 | ribosomal protein S15 | -0.0267033 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0266434 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.026457 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0263232 |
| DEK | DEK proto-oncogene | -0.0261921 |
| MATR3 | matrin 3 | -0.0259302 |
| ACER3 | alkaline ceramidase 3 | -0.0259231 |
| RAB1A | RAB1A, member RAS oncogene family | -0.025762 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0256665 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0255734 |
| RPS23 | ribosomal protein S23 | -0.0249156 |
| XPO1 | exportin 1 | -0.0248636 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0247844 |
| RBM25 | RNA binding motif protein 25 | -0.0246975 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0245966 |
| LIMA1 | LIM domain and actin binding 1 | -0.0242595 |
| KRT17 | keratin 17, type I | -0.0242191 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0240828 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0238778 |
| RPS5 | ribosomal protein S5 | -0.0238369 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0238182 |
