| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib (maleate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.172679 |
| NAV3 | neuron navigator 3 | 0.170914 |
| EXT1 | exostosin glycosyltransferase 1 | 0.16267 |
| TXNRD1 | thioredoxin reductase 1 | 0.137136 |
| ANK2 | ankyrin 2, neuronal | 0.125089 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.11498 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.114335 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0974214 |
| MCL1 | myeloid cell leukemia 1 | 0.0972181 |
| STC1 | stanniocalcin 1 | 0.0968365 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0947258 |
| RPL3 | ribosomal protein L3 | 0.0944489 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0861269 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0853709 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0799737 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0771502 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0745059 |
| JMJD1C | jumonji domain containing 1C | 0.0731968 |
| HDAC9 | histone deacetylase 9 | 0.0716443 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0702185 |
| CORO1C | coronin, actin binding protein, 1C | 0.0673767 |
| DGKI | diacylglycerol kinase, iota | 0.0660003 |
| RPS18 | ribosomal protein S18 | 0.0651504 |
| ACTG1 | actin gamma 1 | 0.0603633 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0569373 |
| FRMD4A | FERM domain containing 4A | 0.0566777 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0564434 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0563177 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0559627 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0547896 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0540385 |
| RPS12 | ribosomal protein S12 | 0.0520536 |
| UPP1 | uridine phosphorylase 1 | 0.0517789 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0511353 |
| JUN | jun proto-oncogene | 0.0509043 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.050484 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0502336 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0500423 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0486905 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0486176 |
| COG5 | component of oligomeric golgi complex 5 | 0.0481526 |
| ZNF438 | zinc finger protein 438 | 0.046235 |
| FLNB | filamin B, beta | 0.0459278 |
| SGMS2 | sphingomyelin synthase 2 | 0.0459031 |
| FHIT | fragile histidine triad | 0.0452702 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.045145 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0450013 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0444823 |
| ENO1 | enolase 1, (alpha) | 0.0440386 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0437987 |
| APP | amyloid beta (A4) precursor protein | 0.0434423 |
| TPM3 | tropomyosin 3 | 0.0432328 |
| CD68 | CD68 molecule | 0.0424456 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0423336 |
| RPS3 | ribosomal protein S3 | 0.0419946 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0406604 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0404253 |
| DST | dystonin | 0.0399505 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0398239 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0393496 |
| TPM4 | tropomyosin 4 | 0.0389037 |
| GLRX | glutaredoxin (thioltransferase) | 0.0385433 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0382964 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0380275 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0376605 |
| UBC | ubiquitin C | 0.0364805 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0364495 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0350615 |
| RPS2 | ribosomal protein S2 | 0.0344981 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0344923 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0341111 |
| CCNY | cyclin Y | 0.0335129 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0334445 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0330029 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0328057 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0320582 |
| CARD16 | caspase recruitment domain family, member 16 | 0.031894 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0317917 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0316706 |
| PCBP2 | poly(rC) binding protein 2 | 0.0314046 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0312506 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0311369 |
| SMYD3 | SET and MYND domain containing 3 | 0.0311335 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0311293 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0310757 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0308974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0308321 |
| RACK1 | receptor for activated C kinase 1 | 0.0308234 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0306217 |
| CAPRIN2 | caprin family member 2 | 0.0301822 |
| MAP4 | microtubule-associated protein 4 | 0.0297725 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0296949 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0296521 |
| EXOC6B | exocyst complex component 6B | 0.0295172 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0295 |
| PGK1 | phosphoglycerate kinase 1 | 0.029263 |
| LIMA1 | LIM domain and actin binding 1 | 0.0291446 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0287513 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0287417 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0284146 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.139112 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0780011 |
| RPL35A | ribosomal protein L35a | -0.0758049 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0665489 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.060422 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0596468 |
| TTR | transthyretin | -0.0553551 |
| RPS24 | ribosomal protein S24 | -0.0538371 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0516148 |
| PTMA | prothymosin, alpha | -0.0508214 |
| RPS21 | ribosomal protein S21 | -0.0496182 |
| MKI67 | marker of proliferation Ki-67 | -0.0473288 |
| MT1X | metallothionein 1X | -0.0445714 |
| DIAPH3 | diaphanous-related formin 3 | -0.0418262 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0418057 |
| RAB3IP | RAB3A interacting protein | -0.0406388 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0403092 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0393162 |
| DEK | DEK proto-oncogene | -0.0356405 |
| CENPF | centromere protein F, 350/400kDa | -0.0352144 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0333249 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0318939 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0303831 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0303778 |
| RPL34 | ribosomal protein L34 | -0.0296366 |
| ERBIN | erbb2 interacting protein | -0.0292719 |
| PFN1 | profilin 1 | -0.0292197 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0290508 |
| PCNX4 | pecanex 4 | -0.0290058 |
| HMGA2 | high mobility group AT-hook 2 | -0.0285498 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0272921 |
| HELLS | helicase, lymphoid-specific | -0.0272232 |
| HMGB1 | high mobility group box 1 | -0.0270594 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0269446 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0265594 |
| HMGB2 | high mobility group box 2 | -0.0262182 |
| MTAP | methylthioadenosine phosphorylase | -0.0261643 |
| S100A9 | S100 calcium binding protein A9 | -0.0254445 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0252588 |
| RRM2 | ribonucleotide reductase M2 | -0.0249733 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.024895 |
| RPS15 | ribosomal protein S15 | -0.0241846 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.023812 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0232206 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0231246 |
| RPL8 | ribosomal protein L8 | -0.0223511 |
| B2M | beta-2-microglobulin | -0.0220141 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0217977 |
| RPL23 | ribosomal protein L23 | -0.0217774 |
| GNAS | GNAS complex locus | -0.0217236 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0214291 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0213402 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0212998 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0210846 |
| RPS11 | ribosomal protein S11 | -0.0208066 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0206114 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0205672 |
| BNC2 | basonuclin 2 | -0.0204713 |
| RPLP0 | ribosomal protein, large, P0 | -0.0204205 |
| RPL32 | ribosomal protein L32 | -0.0197655 |
| PHIP | pleckstrin homology domain interacting protein | -0.0196082 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0190968 |
| RPLP1 | ribosomal protein, large, P1 | -0.0190625 |
| NOP56 | NOP56 ribonucleoprotein | -0.0188522 |
| MX2 | MX dynamin-like GTPase 2 | -0.0186674 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0186272 |
| RPLP2 | ribosomal protein, large, P2 | -0.0179797 |
| TUBA1B | tubulin, alpha 1b | -0.0177698 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0177671 |
| FUS | FUS RNA binding protein | -0.0177463 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0175921 |
| MCM4 | minichromosome maintenance complex component 4 | -0.0174578 |
| KIF20B | kinesin family member 20B | -0.0173974 |
| TPX2 | TPX2, microtubule-associated | -0.0173641 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0173493 |
| RRBP1 | ribosome binding protein 1 | -0.017103 |
| RIGI | RNA sensor RIG-I | -0.0170216 |
| CBX3 | chromobox homolog 3 | -0.0169766 |
| RPS27A | ribosomal protein S27a | -0.0169335 |
| VDAC1 | voltage-dependent anion channel 1 | -0.016928 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0168511 |
| FANCI | Fanconi anemia, complementation group I | -0.0168303 |
| CDC27 | cell division cycle 27 | -0.0164014 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.016166 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0161462 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0158938 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0158672 |
| SNX14 | sorting nexin 14 | -0.0158375 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0157887 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.0157853 |
| TUBB | tubulin, beta class I | -0.0157247 |
| ATAD5 | ATPase family, AAA domain containing 5 | -0.0154573 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0152863 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0148682 |
| KNL1 | kinetochore scaffold 1 | -0.0148517 |
| ECT2 | epithelial cell transforming 2 | -0.0148096 |
| ENY2 | enhancer of yellow 2 homolog (Drosophila) | -0.0146637 |
| RPL30 | ribosomal protein L30 | -0.0144793 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0144425 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.014359 |
