| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.125405 |
| MT2A | metallothionein 2A | 0.097608 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0803916 |
| NRP1 | neuropilin 1 | 0.0803121 |
| FHIT | fragile histidine triad | 0.078963 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0766925 |
| LOXL2 | lysyl oxidase-like 2 | 0.0754158 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0681028 |
| FLNB | filamin B, beta | 0.0673339 |
| PLEC | plectin | 0.066451 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0643377 |
| FMNL2 | formin-like 2 | 0.0629339 |
| VEGFA | vascular endothelial growth factor A | 0.060014 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0583741 |
| TXNRD1 | thioredoxin reductase 1 | 0.056663 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0557771 |
| RAD51B | RAD51 paralog B | 0.0551474 |
| FTL | ferritin, light polypeptide | 0.054238 |
| AHNAK | AHNAK nucleoprotein | 0.052932 |
| PGK1 | phosphoglycerate kinase 1 | 0.0522264 |
| NAV2 | neuron navigator 2 | 0.0522035 |
| MLPH | melanophilin | 0.0491439 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0479465 |
| ASPH | aspartate beta-hydroxylase | 0.0463554 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0451477 |
| RNF213 | ring finger protein 213 | 0.0447023 |
| MAP4 | microtubule-associated protein 4 | 0.0435243 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0435046 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0433546 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0431601 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0426634 |
| DST | dystonin | 0.0414485 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0411916 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0411536 |
| ANXA2 | annexin A2 | 0.0406317 |
| HDAC9 | histone deacetylase 9 | 0.0397482 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0386143 |
| DNAAF9 | dynein axonemal assembly factor 9 | 0.0378686 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0377322 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0376102 |
| TOX2 | TOX high mobility group box family member 2 | 0.0371718 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0369435 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0365683 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0356781 |
| RND3 | Rho family GTPase 3 | 0.0355389 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0346447 |
| PFKP | phosphofructokinase, platelet | 0.0342428 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0340624 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.033887 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0338391 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0335337 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.033397 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0333472 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0325629 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0325367 |
| ZNF148 | zinc finger protein 148 | 0.0324007 |
| ECE1 | endothelin converting enzyme 1 | 0.032361 |
| YEATS2 | YEATS domain containing 2 | 0.0322428 |
| RPLP1 | ribosomal protein, large, P1 | 0.032117 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.032004 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0319843 |
| OPTN | optineurin | 0.0319204 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0317468 |
| SETBP1 | SET binding protein 1 | 0.0316806 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0312974 |
| AFAP1 | actin filament associated protein 1 | 0.0310273 |
| TMEM132D | transmembrane protein 132D | 0.030913 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0308999 |
| ANK2 | ankyrin 2, neuronal | 0.03062 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0304279 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0299202 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0297352 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0297076 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0295287 |
| WWOX | WW domain containing oxidoreductase | 0.0293442 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0292921 |
| ADAR | adenosine deaminase, RNA-specific | 0.0292256 |
| MX1 | MX dynamin-like GTPase 1 | 0.0291118 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0288697 |
| AFDN | afadin, adherens junction formation factor | 0.0288292 |
| SMYD3 | SET and MYND domain containing 3 | 0.0285538 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0282599 |
| COL5A1 | collagen, type V, alpha 1 | 0.0282495 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0280734 |
| FAT1 | FAT atypical cadherin 1 | 0.0278656 |
| OSMR | oncostatin M receptor | 0.0276823 |
| CDCP1 | CUB domain containing protein 1 | 0.0275022 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0274474 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0273909 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0271824 |
| FOSL1 | FOS-like antigen 1 | 0.0271624 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0270425 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0270099 |
| MAP1B | microtubule-associated protein 1B | 0.0269448 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0268448 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0268392 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.0267772 |
| SUMF1 | sulfatase modifying factor 1 | 0.0263709 |
| CTSL | cathepsin L | 0.0263491 |
| TGM2 | transglutaminase 2 | 0.0263279 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.135428 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.116386 |
| VIM | vimentin | -0.113029 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.112947 |
| COL1A1 | collagen, type I, alpha 1 | -0.10961 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0944246 |
| FRMD4A | FERM domain containing 4A | -0.0908351 |
| FN1 | fibronectin 1 | -0.0905893 |
| FNDC3B | fibronectin type III domain containing 3B | -0.088573 |
| STC1 | stanniocalcin 1 | -0.079203 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0732552 |
| PCBP3 | poly(rC) binding protein 3 | -0.0703053 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0702404 |
| CDH13 | cadherin 13 | -0.0653098 |
| EXT1 | exostosin glycosyltransferase 1 | -0.059924 |
| RPS27A | ribosomal protein S27a | -0.054051 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0538174 |
| GLIS3 | GLIS family zinc finger 3 | -0.0532218 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0524607 |
| TMSB10 | thymosin beta 10 | -0.0524192 |
| INTS6 | integrator complex subunit 6 | -0.0520356 |
| INHBA | inhibin, beta A | -0.0513669 |
| UBC | ubiquitin C | -0.0499916 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0493605 |
| TNNC1 | troponin C type 1 (slow) | -0.0482566 |
| ITGA1 | integrin, alpha 1 | -0.047891 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0473428 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0452145 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0445605 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0437027 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.042854 |
| CCDC138 | coiled-coil domain containing 138 | -0.0414286 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0405325 |
| THBS1 | thrombospondin 1 | -0.0393305 |
| EGR1 | early growth response 1 | -0.03905 |
| NABP1 | nucleic acid binding protein 1 | -0.0390275 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0380145 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0377631 |
| VCL | vinculin | -0.0355163 |
| ARF4 | ADP-ribosylation factor 4 | -0.0354248 |
| GOLGA4 | golgin A4 | -0.0349897 |
| SEC24D | SEC24 family member D | -0.0349671 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0346856 |
| PDE10A | phosphodiesterase 10A | -0.0346796 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0346221 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0338222 |
| COPA | coatomer protein complex, subunit alpha | -0.0333726 |
| SHISA5 | shisa family member 5 | -0.0330705 |
| COL5A3 | collagen, type V, alpha 3 | -0.032575 |
| PTMA | prothymosin, alpha | -0.0321481 |
| LOX | lysyl oxidase | -0.0315397 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0299043 |
| IER3 | immediate early response 3 | -0.0294611 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0292636 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0292523 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | -0.028824 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0285293 |
| TMEM178B | transmembrane protein 178B | -0.0284826 |
| SNX14 | sorting nexin 14 | -0.0282401 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0282237 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.027591 |
| TOP1 | topoisomerase (DNA) I | -0.0269849 |
| IPO9 | importin 9 | -0.0269478 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0268561 |
| DENND4A | DENN/MADD domain containing 4A | -0.0267315 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0266636 |
| TGFB1 | transforming growth factor, beta 1 | -0.0266455 |
| TFG | TRK-fused gene | -0.0263686 |
| CFAP44 | cilia and flagella associated protein 44 | -0.0263473 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0261426 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0261303 |
| CALU | calumenin | -0.0257582 |
| KYNU | kynureninase | -0.0254383 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0253493 |
| PGM3 | phosphoglucomutase 3 | -0.0247938 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0247392 |
| OXR1 | oxidation resistance 1 | -0.0247064 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0245357 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0244797 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0243757 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.0243467 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0243294 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0242202 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0242049 |
| SEC24A | SEC24 family member A | -0.0240775 |
| DNAJB11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | -0.0240526 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0236271 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0235734 |
| IL1B | interleukin 1, beta | -0.0235552 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0230786 |
| CANX | calnexin | -0.0229103 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0227637 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0227143 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0225437 |
| ACTG1 | actin gamma 1 | -0.0224955 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.0224916 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0223018 |
| HMGA2 | high mobility group AT-hook 2 | -0.0222576 |
| HLA-B | major histocompatibility complex, class I, B | -0.0221928 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.0221227 |
