| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VGF | VGF nerve growth factor inducible | 0.225465 |
| PDE10A | phosphodiesterase 10A | 0.153341 |
| ENO1 | enolase 1, (alpha) | 0.101922 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0942015 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0939469 |
| MAP1B | microtubule-associated protein 1B | 0.0783657 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0750503 |
| MCL1 | myeloid cell leukemia 1 | 0.0704991 |
| STC1 | stanniocalcin 1 | 0.0642936 |
| TPM3 | tropomyosin 3 | 0.0642438 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0616784 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0604216 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0594224 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0526521 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0491128 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0490731 |
| ADAR | adenosine deaminase, RNA-specific | 0.0478248 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0476027 |
| RNF213 | ring finger protein 213 | 0.0473044 |
| PCBP2 | poly(rC) binding protein 2 | 0.0472726 |
| MT2A | metallothionein 2A | 0.0472498 |
| CHGB | chromogranin B | 0.0459917 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0448847 |
| SET | SET nuclear proto-oncogene | 0.0439479 |
| EZR | ezrin | 0.0420877 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0400029 |
| PGK1 | phosphoglycerate kinase 1 | 0.0388452 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0380912 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0362895 |
| ASPH | aspartate beta-hydroxylase | 0.0361714 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0361046 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0358019 |
| DST | dystonin | 0.0352796 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0347442 |
| RPS18 | ribosomal protein S18 | 0.0338909 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0338112 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0323897 |
| TMEM255B | transmembrane protein 255B | 0.0321817 |
| MSN | moesin | 0.0318245 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0315681 |
| PKM | pyruvate kinase, muscle | 0.03145 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0305651 |
| FAM13A | family with sequence similarity 13, member A | 0.0304755 |
| NDRG1 | N-myc downstream regulated 1 | 0.0302632 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0302614 |
| TPM4 | tropomyosin 4 | 0.0293306 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0291965 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.029146 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.028814 |
| RPL3 | ribosomal protein L3 | 0.0286299 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0284849 |
| FLNB | filamin B, beta | 0.0281124 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0280782 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0280496 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0277005 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0276082 |
| POTEF | POTE ankyrin domain family, member F | 0.0272923 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0269344 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0268641 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0267868 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0265834 |
| MACROD2 | MACRO domain containing 2 | 0.0264917 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0263825 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0258867 |
| ZNF395 | zinc finger protein 395 | 0.025838 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0255146 |
| SMAD9 | SMAD family member 9 | 0.0250511 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0248704 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.024692 |
| VEGFA | vascular endothelial growth factor A | 0.024541 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0243416 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0243021 |
| WWOX | WW domain containing oxidoreductase | 0.0241068 |
| RPS27 | ribosomal protein S27 | 0.0239364 |
| FBL | fibrillarin | 0.0234458 |
| XPOT | exportin, tRNA | 0.0233878 |
| PARVB | parvin, beta | 0.0231852 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.0231049 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0230571 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0230468 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.0230291 |
| MATR3 | matrin 3 | 0.0229709 |
| PDE8A | phosphodiesterase 8A | 0.0228538 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0227393 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0222613 |
| RAD51B | RAD51 paralog B | 0.0219695 |
| KIF1A | kinesin family member 1A | 0.0219662 |
| FOXK1 | forkhead box K1 | 0.0218738 |
| RPS3 | ribosomal protein S3 | 0.0218409 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0217017 |
| SEPTIN9 | septin 9 | 0.0215488 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0214006 |
| POU6F2 | POU class 6 homeobox 2 | 0.0212731 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0212579 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0211663 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0211638 |
| RPS6 | ribosomal protein S6 | 0.0209597 |
| UNC13A | unc-13 homolog A (C. elegans) | 0.0207814 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0207668 |
| CEP250 | centrosomal protein 250kDa | 0.0207157 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.136626 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.106049 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0853564 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0853159 |
| SNTG1 | syntrophin, gamma 1 | -0.07669 |
| CALCA | calcitonin-related polypeptide alpha | -0.0746635 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0677827 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0673977 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0661005 |
| PTCHD4 | patched domain containing 4 | -0.0631897 |
| CNKSR3 | CNKSR family member 3 | -0.062233 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0616055 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.058646 |
| GPC5 | glypican 5 | -0.054892 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.05437 |
| RIT2 | Ras-like without CAAX 2 | -0.0462334 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0459481 |
| ATF6 | activating transcription factor 6 | -0.0452573 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.045195 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0449512 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.043607 |
| ACTG1 | actin gamma 1 | -0.0434282 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0424642 |
| FGF14 | fibroblast growth factor 14 | -0.0415343 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0410869 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.040887 |
| NCKAP5 | NCK-associated protein 5 | -0.0403885 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0399195 |
| ZNF804A | zinc finger protein 804A | -0.0396161 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0390291 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0388989 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0383479 |
| TMSB4X | thymosin beta 4, X-linked | -0.038014 |
| RPS21 | ribosomal protein S21 | -0.0370475 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0364798 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0359076 |
| SIK3 | SIK family kinase 3 | -0.0356292 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0355481 |
| NELL1 | NEL-like 1 (chicken) | -0.033763 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0336287 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.033563 |
| ESRRG | estrogen-related receptor gamma | -0.0335544 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0327151 |
| HOMER1 | homer scaffolding protein 1 | -0.0327061 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0322276 |
| NTS | neurotensin | -0.0320808 |
| NF1 | neurofibromin 1 | -0.0320413 |
| CUL3 | cullin 3 | -0.0319331 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0313311 |
| PEG10 | paternally expressed 10 | -0.0304495 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0302771 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0301501 |
| DENND4A | DENN/MADD domain containing 4A | -0.029555 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0292863 |
| TOX | thymocyte selection-associated high mobility group box | -0.0291684 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0287556 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0285703 |
| CADM1 | cell adhesion molecule 1 | -0.0284385 |
| PTMA | prothymosin, alpha | -0.0278015 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.027562 |
| GOLGB1 | golgin B1 | -0.0274238 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0271879 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0267482 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0264913 |
| CLTC | clathrin, heavy chain (Hc) | -0.0263617 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0263519 |
| INHBA | inhibin, beta A | -0.0261129 |
| KIAA0825 | KIAA0825 | -0.0259554 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0259472 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0256458 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0255722 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0253942 |
| CDK13 | cyclin-dependent kinase 13 | -0.0253883 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0239309 |
| MMP26 | matrix metallopeptidase 26 | -0.0233731 |
| S100A9 | S100 calcium binding protein A9 | -0.0232379 |
| CA8 | carbonic anhydrase VIII | -0.0231921 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0231609 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0231513 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0230865 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0229841 |
| AGMO | alkylglycerol monooxygenase | -0.0229746 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0227531 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0226231 |
| TENM1 | teneurin transmembrane protein 1 | -0.0225822 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0225333 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0224918 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0223862 |
| FUS | FUS RNA binding protein | -0.0221152 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0220774 |
| SCFD2 | sec1 family domain containing 2 | -0.022038 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0218516 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | -0.0217981 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.021655 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0216131 |
| SATB2 | SATB homeobox 2 | -0.0215184 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.0214416 |
| TRIM9 | tripartite motif containing 9 | -0.0214261 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0213195 |
| FN1 | fibronectin 1 | -0.0212406 |
