| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.246899 |
| FN1 | fibronectin 1 | 0.182751 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.160647 |
| HDAC9 | histone deacetylase 9 | 0.160251 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0916864 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0911483 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0878784 |
| MSN | moesin | 0.0791075 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0777433 |
| DST | dystonin | 0.0766519 |
| RASAL2 | RAS protein activator like 2 | 0.0749037 |
| SLC39A11 | solute carrier family 39, member 11 | 0.072482 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0714037 |
| RAD51B | RAD51 paralog B | 0.0685227 |
| TXNRD1 | thioredoxin reductase 1 | 0.0628168 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0622429 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0619653 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.060139 |
| FRMD4A | FERM domain containing 4A | 0.0593447 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0567266 |
| FMNL2 | formin-like 2 | 0.0552316 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0547248 |
| MAP4 | microtubule-associated protein 4 | 0.0521809 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0519715 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0502883 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0489826 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0475471 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0471402 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0470175 |
| NAV2 | neuron navigator 2 | 0.0452674 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.045137 |
| PKM | pyruvate kinase, muscle | 0.0435176 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0429271 |
| SEPTIN9 | septin 9 | 0.0428565 |
| TPM3 | tropomyosin 3 | 0.0425298 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0416382 |
| EHBP1 | EH domain binding protein 1 | 0.0414345 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0405247 |
| SUMF1 | sulfatase modifying factor 1 | 0.0397976 |
| MSI2 | musashi RNA-binding protein 2 | 0.039573 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0395506 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0389188 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0385662 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0376227 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0375433 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0368341 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0368091 |
| PLEC | plectin | 0.0347149 |
| RNF213 | ring finger protein 213 | 0.0342516 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0341932 |
| PRELID2 | PRELI domain containing 2 | 0.0335441 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.033008 |
| SFTPA2 | surfactant protein A2 | 0.032942 |
| CD44 | CD44 molecule (Indian blood group) | 0.032881 |
| RUNX1 | runt-related transcription factor 1 | 0.0320141 |
| ENO1 | enolase 1, (alpha) | 0.0318466 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0317807 |
| SQSTM1 | sequestosome 1 | 0.0315531 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0308874 |
| FMN1 | formin 1 | 0.0305178 |
| ATXN1 | ataxin 1 | 0.0303849 |
| DIAPH2 | diaphanous-related formin 2 | 0.030035 |
| CTTN | cortactin | 0.0299339 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0295704 |
| VEGFA | vascular endothelial growth factor A | 0.0294606 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0294587 |
| CFAP20DC | CFAP20 domain containing | 0.0292665 |
| EZR | ezrin | 0.0288181 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0288088 |
| PFKP | phosphofructokinase, platelet | 0.0288048 |
| MCL1 | myeloid cell leukemia 1 | 0.0287136 |
| RPL3 | ribosomal protein L3 | 0.0285779 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0285008 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0280586 |
| CCSER2 | coiled-coil serine-rich protein 2 | 0.0280533 |
| FLNA | filamin A, alpha | 0.0278118 |
| TENM3 | teneurin transmembrane protein 3 | 0.0274928 |
| KAZN | kazrin, periplakin interacting protein | 0.0274167 |
| ANK2 | ankyrin 2, neuronal | 0.0273154 |
| FRMD5 | FERM domain containing 5 | 0.0269218 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0264989 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0264903 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0263215 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0263176 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0259837 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0255228 |
| CLIC4 | chloride intracellular channel 4 | 0.0251108 |
| NAV1 | neuron navigator 1 | 0.0250932 |
| CTSB | cathepsin B | 0.0248411 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0246617 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0246089 |
| ANXA2 | annexin A2 | 0.0245744 |
| PCBP2 | poly(rC) binding protein 2 | 0.024531 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0244854 |
| NPC1 | Niemann-Pick disease, type C1 | 0.024032 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0239136 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0238717 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0237425 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0236464 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0235953 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.141852 |
| VIM | vimentin | -0.100131 |
| RPL35A | ribosomal protein L35a | -0.0693363 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0665696 |
| GOLGA4 | golgin A4 | -0.059325 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0531632 |
| RPLP1 | ribosomal protein, large, P1 | -0.0505093 |
| MT2A | metallothionein 2A | -0.0503227 |
| RPS6 | ribosomal protein S6 | -0.0485006 |
| RPS3 | ribosomal protein S3 | -0.0484531 |
| ACTG1 | actin gamma 1 | -0.0459737 |
| RPL23 | ribosomal protein L23 | -0.0420152 |
| RPS24 | ribosomal protein S24 | -0.0401 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0400502 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0396859 |
| RPLP2 | ribosomal protein, large, P2 | -0.0394774 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0394145 |
| RPL34 | ribosomal protein L34 | -0.0388418 |
| RPS21 | ribosomal protein S21 | -0.0387675 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0384035 |
| PTMA | prothymosin, alpha | -0.0378141 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0376917 |
| FTL | ferritin, light polypeptide | -0.036818 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.036328 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0339146 |
| RPL32 | ribosomal protein L32 | -0.031837 |
| RPL11 | ribosomal protein L11 | -0.0309988 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0303337 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0294215 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0290113 |
| RPS23 | ribosomal protein S23 | -0.0287717 |
| CENPF | centromere protein F, 350/400kDa | -0.0287378 |
| S100A9 | S100 calcium binding protein A9 | -0.0286736 |
| RPS8 | ribosomal protein S8 | -0.0284144 |
| RPLP0 | ribosomal protein, large, P0 | -0.027449 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0274394 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0270911 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0269638 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0269307 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0264076 |
| TMSB10 | thymosin beta 10 | -0.0254571 |
| RPS14 | ribosomal protein S14 | -0.0253951 |
| CBX3 | chromobox homolog 3 | -0.0252806 |
| RPL12 | ribosomal protein L12 | -0.0249043 |
| CADM1 | cell adhesion molecule 1 | -0.0247445 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0247342 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0247268 |
| CDK6 | cyclin-dependent kinase 6 | -0.0246959 |
| RPL9 | ribosomal protein L9 | -0.0245949 |
| OGA | O-GlcNAcase | -0.0242396 |
| RPS13 | ribosomal protein S13 | -0.0236195 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0234674 |
| PMEL | premelanosome protein | -0.0231643 |
| RPL5 | ribosomal protein L5 | -0.0231111 |
| RPS4X | ribosomal protein S4, X-linked | -0.0226929 |
| TFRC | transferrin receptor | -0.0225666 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0225425 |
| RPL38 | ribosomal protein L38 | -0.0223695 |
| RPL37A | ribosomal protein L37a | -0.0222719 |
| ANLN | anillin, actin binding protein | -0.0218168 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0216825 |
| RPL28 | ribosomal protein L28 | -0.0216528 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.020962 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0208875 |
| RPS27A | ribosomal protein S27a | -0.020801 |
| RPS29 | ribosomal protein S29 | -0.0207362 |
| RPL4 | ribosomal protein L4 | -0.0207339 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0206387 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0205369 |
| RPL30 | ribosomal protein L30 | -0.0205143 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0205118 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0204771 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0204555 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0201525 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0201187 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0199892 |
| MT1X | metallothionein 1X | -0.0198854 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0198842 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0197569 |
| RPS19 | ribosomal protein S19 | -0.0194238 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0193836 |
| RPS5 | ribosomal protein S5 | -0.0193618 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0193291 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0193109 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0192639 |
| PRAME | preferentially expressed antigen in melanoma | -0.0190047 |
| RACK1 | receptor for activated C kinase 1 | -0.0189805 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0189128 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0188532 |
| TFG | TRK-fused gene | -0.0188028 |
| HELZ | helicase with zinc finger | -0.0187858 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0187478 |
| WDR45B | WD repeat domain 45B | -0.0184881 |
| RPS15 | ribosomal protein S15 | -0.0184313 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0182185 |
| NKTR | natural killer cell triggering receptor | -0.0181727 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0181586 |
| RPS16 | ribosomal protein S16 | -0.0181451 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0177637 |
| TMEM263 | transmembrane protein 263 | -0.0176708 |
