| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.0992766 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0955577 |
| AHNAK | AHNAK nucleoprotein | 0.0874907 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0808121 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0774562 |
| IL6 | interleukin 6 | 0.075741 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0750699 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0735799 |
| MAP1B | microtubule-associated protein 1B | 0.0689545 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0628979 |
| HDAC9 | histone deacetylase 9 | 0.0614861 |
| LOXL2 | lysyl oxidase-like 2 | 0.0596524 |
| SMAD3 | SMAD family member 3 | 0.0575514 |
| SEPTIN9 | septin 9 | 0.0556393 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0554883 |
| EGFR | epidermal growth factor receptor | 0.0536538 |
| CDH13 | cadherin 13 | 0.0529188 |
| APP | amyloid beta (A4) precursor protein | 0.0515618 |
| FMNL2 | formin-like 2 | 0.0515104 |
| NDRG1 | N-myc downstream regulated 1 | 0.0507772 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0490828 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0487741 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0485885 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0484588 |
| STC2 | stanniocalcin 2 | 0.0474329 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.046832 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.046612 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.046553 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0462577 |
| SDC4 | syndecan 4 | 0.0458982 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0453653 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0448162 |
| HLA-A | major histocompatibility complex, class I, A | 0.0440574 |
| RNF145 | ring finger protein 145 | 0.0438877 |
| RND3 | Rho family GTPase 3 | 0.043787 |
| TPM3 | tropomyosin 3 | 0.0433785 |
| ASPH | aspartate beta-hydroxylase | 0.043192 |
| ZNF395 | zinc finger protein 395 | 0.0429327 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0426648 |
| CADM1 | cell adhesion molecule 1 | 0.0415153 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0411901 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0411866 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0411235 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0399639 |
| ECE1 | endothelin converting enzyme 1 | 0.0392413 |
| PLEC | plectin | 0.0386283 |
| RNF24 | ring finger protein 24 | 0.0384001 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0373337 |
| UBC | ubiquitin C | 0.0368379 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0366888 |
| ENO1 | enolase 1, (alpha) | 0.0353747 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0353495 |
| MAP4 | microtubule-associated protein 4 | 0.0344982 |
| STC1 | stanniocalcin 1 | 0.0343973 |
| FLNA | filamin A, alpha | 0.0342917 |
| AFDN | afadin, adherens junction formation factor | 0.0341455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0340874 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0339618 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0333214 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0331806 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0325488 |
| NAV2 | neuron navigator 2 | 0.0320654 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0318041 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0315581 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0313654 |
| RPS18 | ribosomal protein S18 | 0.0307538 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0307431 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0306032 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0305889 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0305605 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0299599 |
| ARRDC3 | arrestin domain containing 3 | 0.0298553 |
| EFNA5 | ephrin-A5 | 0.029506 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0293968 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0291775 |
| PRELID2 | PRELI domain containing 2 | 0.0289083 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0289049 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0287186 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0285136 |
| EXOC4 | exocyst complex component 4 | 0.0281852 |
| MYADM | myeloid-associated differentiation marker | 0.0280362 |
| AUTS2 | autism susceptibility candidate 2 | 0.0279396 |
| PHF14 | PHD finger protein 14 | 0.0277614 |
| YBX1 | Y box binding protein 1 | 0.027691 |
| SMYD3 | SET and MYND domain containing 3 | 0.027471 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0272904 |
| RPS12 | ribosomal protein S12 | 0.0272806 |
| JAZF1 | JAZF zinc finger 1 | 0.02716 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0269994 |
| TRIM56 | tripartite motif containing 56 | 0.0269734 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0268456 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0265983 |
| PCBP2 | poly(rC) binding protein 2 | 0.0265432 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0265132 |
| ATF4 | activating transcription factor 4 | 0.0261714 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0261642 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0256475 |
| CCDC14 | coiled-coil domain containing 14 | 0.0255616 |
| MCL1 | myeloid cell leukemia 1 | 0.0252942 |
| CDK13 | cyclin-dependent kinase 13 | 0.0250855 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.289959 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.209656 |
| COL1A1 | collagen, type I, alpha 1 | -0.173444 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.162982 |
| COL1A2 | collagen, type I, alpha 2 | -0.14291 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.13163 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.126577 |
| LOX | lysyl oxidase | -0.117387 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.109231 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101234 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.100951 |
| VCL | vinculin | -0.0974882 |
| HLA-B | major histocompatibility complex, class I, B | -0.0867865 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0856093 |
| PRSS23 | protease, serine, 23 | -0.0812368 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0755531 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0726045 |
| CALD1 | caldesmon 1 | -0.0682103 |
| VIM | vimentin | -0.0676905 |
| HMGA2 | high mobility group AT-hook 2 | -0.0661402 |
| CALU | calumenin | -0.0628735 |
| TMSB10 | thymosin beta 10 | -0.0623798 |
| ACTG1 | actin gamma 1 | -0.0580346 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0552016 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0537805 |
| PTMA | prothymosin, alpha | -0.0484352 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0483709 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0478509 |
| TPM1 | tropomyosin 1 (alpha) | -0.0477627 |
| COL3A1 | collagen, type III, alpha 1 | -0.0471921 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0464403 |
| RRBP1 | ribosome binding protein 1 | -0.0452593 |
| THBS1 | thrombospondin 1 | -0.0448804 |
| MT1X | metallothionein 1X | -0.0446215 |
| COL5A1 | collagen, type V, alpha 1 | -0.0445047 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | -0.0405653 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0398207 |
| KAZN | kazrin, periplakin interacting protein | -0.0392525 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0383837 |
| TNNC1 | troponin C type 1 (slow) | -0.037848 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0372181 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0371336 |
| PTGES2 | prostaglandin E synthase 2 | -0.0365456 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0359058 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0355725 |
| FRMD4A | FERM domain containing 4A | -0.0350572 |
| LAMB1 | laminin, beta 1 | -0.0348145 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0341209 |
| SEC24D | SEC24 family member D | -0.0338051 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0335241 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0331785 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0329695 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0326888 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0326853 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0326269 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0315133 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0313943 |
| TUBA1B | tubulin, alpha 1b | -0.0312126 |
| GLG1 | golgi glycoprotein 1 | -0.0297849 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0296991 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0293697 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0291566 |
| THY1 | Thy-1 cell surface antigen | -0.0290777 |
| MORF4L2 | mortality factor 4 like 2 | -0.0285781 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0284683 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0281778 |
| POTEF | POTE ankyrin domain family, member F | -0.0278214 |
| HLA-C | major histocompatibility complex, class I, C | -0.0275677 |
| TPM4 | tropomyosin 4 | -0.0274926 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0273523 |
| RAB2A | RAB2A, member RAS oncogene family | -0.027298 |
| PLCB4 | phospholipase C, beta 4 | -0.0270233 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0269288 |
| OXR1 | oxidation resistance 1 | -0.0266022 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0262274 |
| RRM2 | ribonucleotide reductase M2 | -0.0261312 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0253485 |
| MT2A | metallothionein 2A | -0.0251457 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0248756 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.024778 |
| ITGAV | integrin, alpha V | -0.0245536 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0242899 |
| COL5A2 | collagen, type V, alpha 2 | -0.0241879 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0241002 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0239841 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0237027 |
| GLIS3 | GLIS family zinc finger 3 | -0.0236618 |
| GOLGA4 | golgin A4 | -0.0234326 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0230831 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0230736 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0228063 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0227469 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0223809 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0223586 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0221961 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0221332 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0218818 |
| TAPBP | TAP binding protein (tapasin) | -0.0215368 |
| SEPTIN11 | septin 11 | -0.0215238 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0214438 |
