Neratinib (maleate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib (maleate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib (maleate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.112911
ANKRD11 ankyrin repeat domain 11 0.103281
TXNRD1 thioredoxin reductase 1 0.0963877
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0843381
AHNAK2 AHNAK nucleoprotein 2 0.0776123
MSN moesin 0.0722681
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.072253
MAP1B microtubule-associated protein 1B 0.0715555
PKM pyruvate kinase, muscle 0.0687718
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0674189
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0664733
PCBP2 poly(rC) binding protein 2 0.0644016
MACF1 microtubule-actin crosslinking factor 1 0.062872
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0608844
SQSTM1 sequestosome 1 0.0608764
FLNB filamin B, beta 0.0603771
PLEC plectin 0.0602009
CEP250 centrosomal protein 250kDa 0.0589024
AKAP12 A kinase (PRKA) anchor protein 12 0.0577558
RPS12 ribosomal protein S12 0.057319
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0572814
IGFBP3 insulin-like growth factor binding protein 3 0.0572361
EEF2 eukaryotic translation elongation factor 2 0.0553322
NFE2L1 nuclear factor, erythroid 2-like 1 0.0548122
ITGB4 integrin, beta 4 0.0534762
IARS1 isoleucyl-tRNA synthetase 1 0.053391
TPI1 triosephosphate isomerase 1 0.0524826
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0515081
ANXA2 annexin A2 0.0498159
MYH9 myosin, heavy chain 9, non-muscle 0.0468043
PDCD6IP programmed cell death 6 interacting protein 0.0459146
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0456558
EIF5 eukaryotic translation initiation factor 5 0.0453616
EIF1 eukaryotic translation initiation factor 1 0.0449554
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0448737
SLMAP sarcolemma associated protein 0.0443116
SET SET nuclear proto-oncogene 0.0427635
XPOT exportin, tRNA 0.0426727
KTN1 kinectin 1 (kinesin receptor) 0.0407481
UGCG UDP-glucose ceramide glucosyltransferase 0.0405866
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0402213
MARS1 methionyl-tRNA synthetase 1 0.0392502
LAMA5 laminin, alpha 5 0.0390648
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0388535
KLF12 Kruppel-like factor 12 0.0384999
ENO1 enolase 1, (alpha) 0.0380622
PCLO piccolo presynaptic cytomatrix protein 0.0379358
SMAD3 SMAD family member 3 0.0378961
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0378695
NUMA1 nuclear mitotic apparatus protein 1 0.0374541
RPS3 ribosomal protein S3 0.0373237
FLNA filamin A, alpha 0.0372312
UBC ubiquitin C 0.0372182
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0369532
GARS1 glycyl-tRNA synthetase 1 0.036911
SMYD3 SET and MYND domain containing 3 0.0368415
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0365349
TPM3 tropomyosin 3 0.0362105
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0361415
FTL ferritin, light polypeptide 0.0348208
PGK1 phosphoglycerate kinase 1 0.0346434
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0342951
NIBAN1 niban apoptosis regulator 1 0.0338946
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0338097
YARS1 tyrosyl-tRNA synthetase 1 0.0337247
ECPAS Ecm29 proteasome adaptor and scaffold 0.0335458
PICALM phosphatidylinositol binding clathrin assembly protein 0.033049
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0325877
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0325665
ARHGAP5 Rho GTPase activating protein 5 0.031961
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317454
ITCH itchy E3 ubiquitin protein ligase 0.0314889
ANXA1 annexin A1 0.0309842
CFH complement factor H 0.0307875
RPS18 ribosomal protein S18 0.0307524
TES testin LIM domain protein 0.030672
SETD5 SET domain containing 5 0.030596
TARS1 threonyl-tRNA synthetase 1 0.0303275
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0301752
TJP1 tight junction protein 1 0.0301379
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0300805
CLIP1 CAP-GLY domain containing linker protein 1 0.0300751
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0300749
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0300591
WWOX WW domain containing oxidoreductase 0.0299155
CCDC91 coiled-coil domain containing 91 0.0297258
PSAT1 phosphoserine aminotransferase 1 0.02915
ATF4 activating transcription factor 4 0.0291002
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0290859
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0290754
RAD51B RAD51 paralog B 0.0289852
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0287728
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.02873
ANKRD36 ankyrin repeat domain 36 0.0287154
MTDH metadherin 0.0282124
TMEM14B transmembrane protein 14B 0.02803
RACK1 receptor for activated C kinase 1 0.0278469
FAM13B family with sequence similarity 13, member B 0.0277397
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0276137
UTRN utrophin 0.0274591

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.133104
CD44 CD44 molecule (Indian blood group) -0.121447
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.118452
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0998361
FNDC3B fibronectin type III domain containing 3B -0.0923509
DNER delta/notch-like EGF repeat containing -0.0825494
VIM vimentin -0.0710546
PTMA prothymosin, alpha -0.0698828
BASP1 brain abundant, membrane attached signal protein 1 -0.0681609
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0646222
LDHA lactate dehydrogenase A -0.0628779
SDC4 syndecan 4 -0.0608716
PRKCA protein kinase C, alpha -0.060048
TM4SF1 transmembrane 4 L six family member 1 -0.0578448
IER3 immediate early response 3 -0.0576884
IGF2 insulin-like growth factor 2 -0.0557412
ATM ATM serine/threonine kinase -0.0556298
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0550375
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0541754
MCTP1 multiple C2 domains, transmembrane 1 -0.0541003
PRR16 proline rich 16 -0.0536096
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0534049
ANGPTL4 angiopoietin-like 4 -0.0513875
NAV2 neuron navigator 2 -0.0512011
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0509491
ELL2 elongation factor, RNA polymerase II, 2 -0.0472112
RIGI RNA sensor RIG-I -0.0471345
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0464792
ATP13A3 ATPase type 13A3 -0.0457904
OSMR oncostatin M receptor -0.0446809
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.044248
INTS6 integrator complex subunit 6 -0.0429034
RSF1 remodeling and spacing factor 1 -0.0419531
NT5E 5'-nucleotidase, ecto (CD73) -0.0418218
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0403073
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0401774
EXT1 exostosin glycosyltransferase 1 -0.0397887
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0375338
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0351425
TAS2R14 taste receptor, type 2, member 14 -0.0348114
COMMD10 COMM domain containing 10 -0.0347333
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0341966
ZBTB20 zinc finger and BTB domain containing 20 -0.0341628
FMN1 formin 1 -0.0337604
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0333692
RGS17 regulator of G-protein signaling 17 -0.0332585
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0330089
SPDL1 spindle apparatus coiled-coil protein 1 -0.0328165
DST dystonin -0.0318913
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0315095
GLS2 glutaminase 2 (liver, mitochondrial) -0.0314626
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0311739
MAML2 mastermind-like 2 (Drosophila) -0.031026
GPC6 glypican 6 -0.0309465
TPST1 tyrosylprotein sulfotransferase 1 -0.0304682
ITGAV integrin, alpha V -0.0301858
IL1RAP interleukin 1 receptor accessory protein -0.0300124
JMJD1C jumonji domain containing 1C -0.0296695
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0296306
CEMIP2 cell migration inducing hyaluronidase 2 -0.0295918
VCL vinculin -0.0294533
MAML3 mastermind-like 3 (Drosophila) -0.0294425
DPYD dihydropyrimidine dehydrogenase -0.0291581
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0290823
ZNF609 zinc finger protein 609 -0.028907
TPT1 tumor protein, translationally-controlled 1 -0.0288122
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0280031
FNDC3A fibronectin type III domain containing 3A -0.027969
NF1 neurofibromin 1 -0.0277606
ETV6 ets variant 6 -0.0277224
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0272691
CYTH1 cytohesin 1 -0.0271657
EXOC4 exocyst complex component 4 -0.0266477
BTG1 B-cell translocation gene 1, anti-proliferative -0.0264652
ZNF207 zinc finger protein 207 -0.0264124
MARCKS myristoylated alanine-rich protein kinase C substrate -0.026047
ZBTB38 zinc finger and BTB domain containing 38 -0.0260339
SBF2 SET binding factor 2 -0.0260263
DENND5B DENN/MADD domain containing 5B -0.025912
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0259009
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0258376
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0255276
BIRC3 baculoviral IAP repeat containing 3 -0.0253039
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0250809
RAI14 retinoic acid induced 14 -0.0250357
MBD5 methyl-CpG binding domain protein 5 -0.0249443
LCORL ligand dependent nuclear receptor corepressor-like -0.0249217
ARHGAP18 Rho GTPase activating protein 18 -0.0248569
RAB1A RAB1A, member RAS oncogene family -0.0246779
VMP1 vacuole membrane protein 1 -0.0243442
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.02415
EPAS1 endothelial PAS domain protein 1 -0.0241396
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0239042
ARMH4 armadillo like helical domain containing 4 -0.0238738
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0236935
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.023543
SPAG9 sperm associated antigen 9 -0.0235398
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0233621
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0233555
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0233404