| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib (maleate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.268099 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.139719 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.130657 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.128513 |
| FN1 | fibronectin 1 | 0.104314 |
| MAP1B | microtubule-associated protein 1B | 0.102419 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0964529 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0887676 |
| AHNAK | AHNAK nucleoprotein | 0.0824563 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0757863 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0753783 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0747998 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0745904 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0742762 |
| OSMR | oncostatin M receptor | 0.0721762 |
| DST | dystonin | 0.0694589 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0686454 |
| LOXL2 | lysyl oxidase-like 2 | 0.0683795 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0680798 |
| SMAD3 | SMAD family member 3 | 0.0663076 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.06596 |
| NRP1 | neuropilin 1 | 0.0655123 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0651349 |
| SFTPA2 | surfactant protein A2 | 0.0623005 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0611231 |
| HMGA2 | high mobility group AT-hook 2 | 0.0599405 |
| TXNRD1 | thioredoxin reductase 1 | 0.0577313 |
| CANX | calnexin | 0.057226 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0561567 |
| TPM3 | tropomyosin 3 | 0.0551883 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0549903 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.054738 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0547306 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0526129 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0511336 |
| RAI14 | retinoic acid induced 14 | 0.0503404 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0498717 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0493848 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0490664 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0486146 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0481483 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0481127 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0470521 |
| EXT1 | exostosin glycosyltransferase 1 | 0.04543 |
| PLIN2 | perilipin 2 | 0.0453776 |
| PTK2 | protein tyrosine kinase 2 | 0.0453381 |
| PLEC | plectin | 0.0435862 |
| VEGFC | vascular endothelial growth factor C | 0.0435344 |
| FLNA | filamin A, alpha | 0.0434848 |
| PRELID2 | PRELI domain containing 2 | 0.0431198 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0429635 |
| SVIL | supervillin | 0.0424027 |
| FAT1 | FAT atypical cadherin 1 | 0.0422904 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0421447 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0417888 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.041566 |
| VIM | vimentin | 0.0412858 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0410216 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0410079 |
| GLIS3 | GLIS family zinc finger 3 | 0.0409182 |
| PKM | pyruvate kinase, muscle | 0.0404422 |
| POTEF | POTE ankyrin domain family, member F | 0.0403451 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0395467 |
| AHR | aryl hydrocarbon receptor | 0.0394345 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0390431 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0381558 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0376522 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0375647 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0375266 |
| TXNIP | thioredoxin interacting protein | 0.0372733 |
| STC2 | stanniocalcin 2 | 0.0368908 |
| SYNJ2 | synaptojanin 2 | 0.0365542 |
| SMYD3 | SET and MYND domain containing 3 | 0.0364004 |
| MLPH | melanophilin | 0.0363909 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0362156 |
| RTN4 | reticulon 4 | 0.0360181 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0354955 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0353375 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0351561 |
| CD44 | CD44 molecule (Indian blood group) | 0.0347868 |
| APP | amyloid beta (A4) precursor protein | 0.0347627 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0346986 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0346509 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0343607 |
| ATXN1 | ataxin 1 | 0.0342416 |
| SEPTIN9 | septin 9 | 0.0342265 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.034201 |
| RNF213 | ring finger protein 213 | 0.0335455 |
| FHL2 | four and a half LIM domains 2 | 0.0334629 |
| SEPTIN10 | septin 10 | 0.0331998 |
| RUNX2 | runt-related transcription factor 2 | 0.0331857 |
| IL6ST | interleukin 6 signal transducer | 0.0331232 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0331007 |
| ENO1 | enolase 1, (alpha) | 0.0327964 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0319829 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0319541 |
| PGK1 | phosphoglycerate kinase 1 | 0.0317664 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0314872 |
| TMEM156 | transmembrane protein 156 | 0.0312374 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0311436 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.15929 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0875227 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.083897 |
| PTMA | prothymosin, alpha | -0.0808766 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0669432 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0646846 |
| HLA-B | major histocompatibility complex, class I, B | -0.049851 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0408929 |
| RPL35A | ribosomal protein L35a | -0.0388465 |
| SQSTM1 | sequestosome 1 | -0.0369423 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0358712 |
| MT2A | metallothionein 2A | -0.0340336 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0315334 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0314499 |
| INTS6 | integrator complex subunit 6 | -0.0312401 |
| FTL | ferritin, light polypeptide | -0.030803 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0305767 |
| IER3 | immediate early response 3 | -0.0295122 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0289306 |
| RPL9 | ribosomal protein L9 | -0.0282806 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0280991 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0263938 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0259941 |
| RPL26 | ribosomal protein L26 | -0.0256567 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0254605 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0251702 |
| RPS24 | ribosomal protein S24 | -0.0225545 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0224609 |
| RPL37A | ribosomal protein L37a | -0.0223008 |
| RPL31 | ribosomal protein L31 | -0.0222931 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0217176 |
| LRRC23 | leucine rich repeat containing 23 | -0.0211494 |
| RPLP1 | ribosomal protein, large, P1 | -0.0211088 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0209825 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0209522 |
| RPS8 | ribosomal protein S8 | -0.0206608 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0204587 |
| RPS6 | ribosomal protein S6 | -0.0193943 |
| RPL34 | ribosomal protein L34 | -0.0193764 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0193165 |
| NOP58 | NOP58 ribonucleoprotein | -0.0191329 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0190287 |
| EGR1 | early growth response 1 | -0.0184887 |
| RPL38 | ribosomal protein L38 | -0.0176609 |
| RPS21 | ribosomal protein S21 | -0.0175474 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0175191 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0172856 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0170079 |
| IL6 | interleukin 6 | -0.017007 |
| CCDC138 | coiled-coil domain containing 138 | -0.0169487 |
| MMP13 | matrix metallopeptidase 13 | -0.0168469 |
| TMSB4X | thymosin beta 4, X-linked | -0.016794 |
| RPS27A | ribosomal protein S27a | -0.0165259 |
| HLA-A | major histocompatibility complex, class I, A | -0.016307 |
| TMSB10 | thymosin beta 10 | -0.0162487 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0158233 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0157863 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0157338 |
| RPS29 | ribosomal protein S29 | -0.0156373 |
| RPS25 | ribosomal protein S25 | -0.0153608 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0152977 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0150615 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0150393 |
| RPS3 | ribosomal protein S3 | -0.0148563 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0148364 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0146885 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0146225 |
| RPS15 | ribosomal protein S15 | -0.0144663 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0143224 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0142777 |
| RPLP2 | ribosomal protein, large, P2 | -0.0142053 |
| KLHL24 | kelch-like family member 24 | -0.0140994 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0138475 |
| ATF6 | activating transcription factor 6 | -0.013798 |
| RPS19 | ribosomal protein S19 | -0.013787 |
| RPL12 | ribosomal protein L12 | -0.0136105 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0135704 |
| CTSD | cathepsin D | -0.0135269 |
| JUN | jun proto-oncogene | -0.0134536 |
| CP | ceruloplasmin (ferroxidase) | -0.0134396 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0134304 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0133669 |
| RPS11 | ribosomal protein S11 | -0.0132985 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0131386 |
| NXN | nucleoredoxin | -0.0131068 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0131021 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0127339 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0125857 |
| LAMB3 | laminin, beta 3 | -0.0125333 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0125151 |
| ITGA1 | integrin, alpha 1 | -0.0125045 |
| YBX3 | Y box binding protein 3 | -0.0124771 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0124765 |
| ZNF10 | zinc finger protein 10 | -0.0123906 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0122981 |
| RPL37 | ribosomal protein L37 | -0.0122338 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0121751 |
| B2M | beta-2-microglobulin | -0.0121622 |
| SCFD2 | sec1 family domain containing 2 | -0.012015 |
| CLINT1 | clathrin interactor 1 | -0.0120141 |
