| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.149271 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.148801 |
| AREG | amphiregulin | 0.130989 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0937462 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0915087 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0910454 |
| TXNRD1 | thioredoxin reductase 1 | 0.077482 |
| DSPP | dentin sialophosphoprotein | 0.0772011 |
| EZR | ezrin | 0.0751174 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0725448 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0694249 |
| AHNAK | AHNAK nucleoprotein | 0.067831 |
| LAMC2 | laminin, gamma 2 | 0.0644769 |
| ANXA1 | annexin A1 | 0.0636459 |
| MYO5B | myosin VB | 0.0635468 |
| RPL3 | ribosomal protein L3 | 0.0591219 |
| PCBP2 | poly(rC) binding protein 2 | 0.0577584 |
| NDRG1 | N-myc downstream regulated 1 | 0.0548551 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0543569 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0534143 |
| RNF43 | ring finger protein 43 | 0.0519073 |
| FERMT1 | fermitin family member 1 | 0.0513569 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0478987 |
| FAT1 | FAT atypical cadherin 1 | 0.0478497 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0465846 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0456835 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0448838 |
| PKM | pyruvate kinase, muscle | 0.0419066 |
| FLNA | filamin A, alpha | 0.0415631 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0414826 |
| RPS18 | ribosomal protein S18 | 0.0410849 |
| CDCP1 | CUB domain containing protein 1 | 0.0409282 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0389426 |
| CPOX | coproporphyrinogen oxidase | 0.0379077 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0376152 |
| POTEF | POTE ankyrin domain family, member F | 0.036701 |
| KLF6 | Kruppel-like factor 6 | 0.0363027 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0361118 |
| NAV2 | neuron navigator 2 | 0.0348544 |
| PLEC | plectin | 0.0344242 |
| HMGA1 | high mobility group AT-hook 1 | 0.0334928 |
| EMP1 | epithelial membrane protein 1 | 0.0334428 |
| ANXA11 | annexin A11 | 0.0333143 |
| ANXA2 | annexin A2 | 0.0331263 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0327056 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0319531 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0318966 |
| EREG | epiregulin | 0.0311531 |
| PFKP | phosphofructokinase, platelet | 0.0306412 |
| TOP1 | topoisomerase (DNA) I | 0.0306093 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0301315 |
| IGSF9B | immunoglobulin superfamily, member 9B | 0.0296808 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0288771 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0288054 |
| KIAA0040 | KIAA0040 | 0.0287172 |
| SNX9 | sorting nexin 9 | 0.0286467 |
| TPM3 | tropomyosin 3 | 0.0284322 |
| TPM4 | tropomyosin 4 | 0.0279351 |
| AXIN2 | axin 2 | 0.0271821 |
| LDHA | lactate dehydrogenase A | 0.0269696 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0267342 |
| TJP1 | tight junction protein 1 | 0.0261973 |
| USP6NL | USP6 N-terminal like | 0.0240207 |
| DST | dystonin | 0.0239027 |
| UPP1 | uridine phosphorylase 1 | 0.0233485 |
| RAB10 | RAB10, member RAS oncogene family | 0.0229873 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0227143 |
| PRELID2 | PRELI domain containing 2 | 0.0221495 |
| RBM25 | RNA binding motif protein 25 | 0.0219256 |
| IL4R | interleukin 4 receptor | 0.0218975 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0218617 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.021662 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0215749 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0213255 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0209617 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0206898 |
| ZFP36 | ZFP36 ring finger protein | 0.020624 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0205685 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.0203642 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0200823 |
| KIF1B | kinesin family member 1B | 0.0200498 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0199622 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0197732 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.0197231 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.019588 |
| DSC3 | desmocollin 3 | 0.0194772 |
| ARRDC3 | arrestin domain containing 3 | 0.0193273 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0192146 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0192079 |
| MOSPD1 | motile sperm domain containing 1 | 0.0188763 |
| CCDC71L | coiled-coil domain containing 71-like | 0.0188 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0185571 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0181611 |
| EPHA2 | EPH receptor A2 | 0.0178999 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0178116 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0175947 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0175417 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.017055 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0168894 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0168814 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.210635 |
| PTMA | prothymosin, alpha | -0.201472 |
| IER3 | immediate early response 3 | -0.124164 |
| VCL | vinculin | -0.110963 |
| RAD51B | RAD51 paralog B | -0.085483 |
| FLOT1 | flotillin 1 | -0.081666 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0814327 |
| TMSB10 | thymosin beta 10 | -0.076602 |
| RPL35A | ribosomal protein L35a | -0.0738952 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0710828 |
| LAMA4 | laminin, alpha 4 | -0.0681908 |
| RPL34 | ribosomal protein L34 | -0.0678063 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.066487 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0653598 |
| HDAC2 | histone deacetylase 2 | -0.0651793 |
| RPS24 | ribosomal protein S24 | -0.065122 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.064479 |
| RPS6 | ribosomal protein S6 | -0.0596583 |
| CUX1 | cut-like homeobox 1 | -0.0591582 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0540969 |
| RPS8 | ribosomal protein S8 | -0.0473394 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0468944 |
| RPL9 | ribosomal protein L9 | -0.0454961 |
| FHIT | fragile histidine triad | -0.0451644 |
| RPL23 | ribosomal protein L23 | -0.0451444 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0451274 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0445028 |
| GPC5 | glypican 5 | -0.042881 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0411639 |
| SQSTM1 | sequestosome 1 | -0.041145 |
| RPL26 | ribosomal protein L26 | -0.0406464 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0405564 |
| RPL12 | ribosomal protein L12 | -0.0398872 |
| MTAP | methylthioadenosine phosphorylase | -0.0383996 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0371938 |
| ABR | active BCR-related | -0.0364171 |
| GPHN | gephyrin | -0.035972 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0354473 |
| EHBP1 | EH domain binding protein 1 | -0.0348661 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0347082 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0346562 |
| RPLP1 | ribosomal protein, large, P1 | -0.0342638 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0333393 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0332466 |
| RPS17 | ribosomal protein S17 | -0.0331886 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0331684 |
| RPS21 | ribosomal protein S21 | -0.0331066 |
| RPLP2 | ribosomal protein, large, P2 | -0.0329897 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0327134 |
| VMP1 | vacuole membrane protein 1 | -0.0325521 |
| RCOR1 | REST corepressor 1 | -0.0321098 |
| RPL37A | ribosomal protein L37a | -0.0319213 |
| CMIP | c-Maf inducing protein | -0.0314241 |
| RPS15 | ribosomal protein S15 | -0.0313844 |
| PARD3 | par-3 family cell polarity regulator | -0.0313427 |
| RPL8 | ribosomal protein L8 | -0.0312745 |
| RPS25 | ribosomal protein S25 | -0.0310294 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0310125 |
| RPS5 | ribosomal protein S5 | -0.0309236 |
| CDK13 | cyclin-dependent kinase 13 | -0.0305052 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0299527 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0295598 |
| RPS19 | ribosomal protein S19 | -0.0290513 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0289627 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0288348 |
| RPS27A | ribosomal protein S27a | -0.0280796 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0274291 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0272377 |
| SETD5 | SET domain containing 5 | -0.0270398 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0269945 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0266839 |
| RPL7A | ribosomal protein L7a | -0.0266488 |
| RPS23 | ribosomal protein S23 | -0.0263483 |
| TNS3 | tensin 3 | -0.026145 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0261216 |
| RUNX2 | runt-related transcription factor 2 | -0.0260868 |
| EGR1 | early growth response 1 | -0.0259506 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.025949 |
| NF1 | neurofibromin 1 | -0.0258264 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.025743 |
| SBF2 | SET binding factor 2 | -0.0256433 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -0.0252291 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0249183 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0247325 |
| NFIA | nuclear factor I/A | -0.024604 |
| RPLP0 | ribosomal protein, large, P0 | -0.0244765 |
| UBAP2 | ubiquitin associated protein 2 | -0.0244287 |
| SMAD3 | SMAD family member 3 | -0.0243793 |
| DOCK5 | dedicator of cytokinesis 5 | -0.024288 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.023959 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0238859 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0235979 |
| RPS16 | ribosomal protein S16 | -0.0233148 |
| RPL11 | ribosomal protein L11 | -0.023234 |
| RTN3 | reticulon 3 | -0.0231535 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0229242 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0228574 |
| FTL | ferritin, light polypeptide | -0.0228429 |
| SMYD3 | SET and MYND domain containing 3 | -0.0227005 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0226993 |
