| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib (maleate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib (maleate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | 0.17895 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.122173 |
| FN1 | fibronectin 1 | 0.119372 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.105318 |
| COL6A3 | collagen, type VI, alpha 3 | 0.104898 |
| AHNAK | AHNAK nucleoprotein | 0.102036 |
| ASPH | aspartate beta-hydroxylase | 0.0892565 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.086436 |
| NDRG1 | N-myc downstream regulated 1 | 0.084793 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0823959 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.076754 |
| MAP1B | microtubule-associated protein 1B | 0.0764 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0711702 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0627927 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0618574 |
| RAI14 | retinoic acid induced 14 | 0.0607811 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0582034 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0573246 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0565818 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0560385 |
| APP | amyloid beta (A4) precursor protein | 0.0553132 |
| PCBP2 | poly(rC) binding protein 2 | 0.0541659 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0532577 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0512673 |
| PLEC | plectin | 0.0504834 |
| NAV2 | neuron navigator 2 | 0.049753 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0486144 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0486058 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0482294 |
| NAV1 | neuron navigator 1 | 0.0481242 |
| HDAC9 | histone deacetylase 9 | 0.0479945 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.046977 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0467839 |
| FMNL2 | formin-like 2 | 0.0459139 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0458403 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0458196 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0450234 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0448548 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0440234 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0435758 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0426133 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0408249 |
| DST | dystonin | 0.0406853 |
| SPAG9 | sperm associated antigen 9 | 0.0404406 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.039831 |
| ENO1 | enolase 1, (alpha) | 0.0394896 |
| VEGFA | vascular endothelial growth factor A | 0.0394383 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0392472 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0382123 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0380431 |
| KLF6 | Kruppel-like factor 6 | 0.0380028 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0369504 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0369075 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0366996 |
| MAP4 | microtubule-associated protein 4 | 0.0365756 |
| ATF4 | activating transcription factor 4 | 0.0364699 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0363318 |
| RAD51B | RAD51 paralog B | 0.0362373 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0359285 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0355099 |
| LDHA | lactate dehydrogenase A | 0.035171 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0348324 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0343128 |
| XPOT | exportin, tRNA | 0.0338915 |
| DIAPH2 | diaphanous-related formin 2 | 0.0332907 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0328556 |
| TPM3 | tropomyosin 3 | 0.0327742 |
| GLIS3 | GLIS family zinc finger 3 | 0.0320232 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0319626 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.031612 |
| MCL1 | myeloid cell leukemia 1 | 0.0307888 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | 0.0307156 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0304678 |
| FLNA | filamin A, alpha | 0.030267 |
| ATXN1 | ataxin 1 | 0.0301933 |
| RNF213 | ring finger protein 213 | 0.0301559 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0300451 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0300082 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0299168 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0298751 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0297855 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0297478 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0295682 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0292935 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0287299 |
| PAPPA2 | pappalysin 2 | 0.0286573 |
| RTN4 | reticulon 4 | 0.0284317 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0282606 |
| SQSTM1 | sequestosome 1 | 0.0281649 |
| MSN | moesin | 0.0281442 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0280537 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.027976 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0273353 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0273108 |
| PKM | pyruvate kinase, muscle | 0.0272298 |
| NCKAP1 | NCK-associated protein 1 | 0.027109 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0269462 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0265095 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0257507 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0255766 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.294573 |
| COL1A2 | collagen, type I, alpha 2 | -0.221268 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.169636 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.168068 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.140305 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125686 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.108744 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0884969 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0882586 |
| HLA-B | major histocompatibility complex, class I, B | -0.0656935 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0641288 |
| COL3A1 | collagen, type III, alpha 1 | -0.0634035 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0605291 |
| COL5A3 | collagen, type V, alpha 3 | -0.0544839 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0532881 |
| OXR1 | oxidation resistance 1 | -0.052543 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0521599 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0492205 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0487547 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0477622 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0475868 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0473716 |
| CCDC102B | coiled-coil domain containing 102B | -0.0471709 |
| INHBA | inhibin, beta A | -0.0467281 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0462922 |
| B2M | beta-2-microglobulin | -0.0448994 |
| NPTX1 | neuronal pentraxin I | -0.0439765 |
| FRMD4A | FERM domain containing 4A | -0.0429958 |
| CALR | calreticulin | -0.0428267 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0427875 |
| CD44 | CD44 molecule (Indian blood group) | -0.0421626 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0420156 |
| GOLGA4 | golgin A4 | -0.0411973 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0402466 |
| EMP1 | epithelial membrane protein 1 | -0.0391528 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0385637 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0380345 |
| FBN1 | fibrillin 1 | -0.0364318 |
| ACTG1 | actin gamma 1 | -0.0343089 |
| RPS6 | ribosomal protein S6 | -0.0336327 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0333802 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0322223 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0308566 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0303084 |
| CAVIN1 | caveolae associated protein 1 | -0.0300466 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0299887 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0299405 |
| ITGA1 | integrin, alpha 1 | -0.028725 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0280604 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0279642 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0274287 |
| NCKAP5 | NCK-associated protein 5 | -0.0272583 |
| CALU | calumenin | -0.0272545 |
| RRBP1 | ribosome binding protein 1 | -0.0268504 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.026792 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0266026 |
| HLA-A | major histocompatibility complex, class I, A | -0.0262897 |
| SEC24D | SEC24 family member D | -0.0260169 |
| RPL35A | ribosomal protein L35a | -0.0259413 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0257226 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0256939 |
| PRSS23 | protease, serine, 23 | -0.025652 |
| TPM4 | tropomyosin 4 | -0.0253707 |
| TMEM165 | transmembrane protein 165 | -0.0251708 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0246492 |
| COL5A2 | collagen, type V, alpha 2 | -0.0243739 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0240604 |
| PRR16 | proline rich 16 | -0.0240538 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0239622 |
| NREP | neuronal regeneration related protein | -0.0239325 |
| ITGA11 | integrin, alpha 11 | -0.0236577 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -0.0234503 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0234388 |
| CDK6 | cyclin-dependent kinase 6 | -0.0234135 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0232348 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0230834 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0227181 |
| COL5A1 | collagen, type V, alpha 1 | -0.0226084 |
| STC1 | stanniocalcin 1 | -0.022333 |
| ADAMTSL1 | ADAMTS-like 1 | -0.022242 |
| TPM1 | tropomyosin 1 (alpha) | -0.0221195 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0221106 |
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | -0.022092 |
| CALD1 | caldesmon 1 | -0.0219987 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0217715 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0217312 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0216967 |
| INSIG1 | insulin induced gene 1 | -0.021586 |
| MYO10 | myosin X | -0.0215611 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0214438 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0214391 |
| VCAN | versican | -0.0211777 |
| RPLP1 | ribosomal protein, large, P1 | -0.0210134 |
| PDE8A | phosphodiesterase 8A | -0.0208782 |
| IER3 | immediate early response 3 | -0.0208542 |
| PTMA | prothymosin, alpha | -0.0204625 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.020357 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.020318 |
| SERF2 | small EDRK-rich factor 2 | -0.0201366 |
| RPL34 | ribosomal protein L34 | -0.0199522 |
