Neratinib Gene Set

Dataset LINCS KinomeScan Kinase Inhibitor Targets
Category physical interactions
Type small molecule
Description A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an ethoxy group at the 7-position. (Chemical Entities of Biological Interest Ontology, CHEBI_61397)
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Genes

20 kinases inhibited by the Neratinib small molecule from the KinomeScan Kinase Inhibitor Targets dataset.

Symbol Name Standardized Value
ERBB3 erb-b2 receptor tyrosine kinase 3 1.36211
EGFR epidermal growth factor receptor 1.36211
STK24 serine/threonine kinase 24 1.33582
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 1.29393
SLK STE20-like kinase 1.25436
STK3 serine/threonine kinase 3 1.25436
STK26 serine/threonine protein kinase 26 1.20983
BLK BLK proto-oncogene, Src family tyrosine kinase 1.1424
LCK LCK proto-oncogene, Src family tyrosine kinase 1.09992
MAP3K3 mitogen-activated protein kinase kinase kinase 3 1.09415
BTK Bruton agammaglobulinemia tyrosine kinase 1.06105
MAP3K4 mitogen-activated protein kinase kinase kinase 4 1.04035
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 1.02071
AXL AXL receptor tyrosine kinase 1.01127
TNIK TRAF2 and NCK interacting kinase 0.984392
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.975893
MINK1 misshapen-like kinase 1 0.9517
MERTK MER proto-oncogene, tyrosine kinase 0.895762
NUAK2 NUAK family, SNF1-like kinase, 2 0.883492
GAK cyclin G associated kinase 0.850157