| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.196666 |
| TMSB10 | thymosin beta 10 | 0.100518 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0900119 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0805252 |
| B2M | beta-2-microglobulin | 0.0759643 |
| FBN1 | fibrillin 1 | 0.0678182 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0654187 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0652319 |
| LDHA | lactate dehydrogenase A | 0.0572074 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0504397 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0487751 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0452021 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0427077 |
| ANXA2 | annexin A2 | 0.0413981 |
| SUCNR1 | succinate receptor 1 | 0.0382903 |
| S100A6 | S100 calcium binding protein A6 | 0.0380052 |
| TAGLN2 | transgelin 2 | 0.03709 |
| HLA-E | major histocompatibility complex, class I, E | 0.0357714 |
| CANX | calnexin | 0.0346505 |
| CALR | calreticulin | 0.0345218 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0327713 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0320058 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0318327 |
| MSI2 | musashi RNA-binding protein 2 | 0.0315243 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0309864 |
| MEIS2 | Meis homeobox 2 | 0.0308284 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0306845 |
| GOLGA2 | golgin A2 | 0.0304924 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0293791 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0292698 |
| PTMA | prothymosin, alpha | 0.0287775 |
| COL1A2 | collagen, type I, alpha 2 | 0.0275195 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0272492 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0271056 |
| MYADM | myeloid-associated differentiation marker | 0.0270398 |
| FTL | ferritin, light polypeptide | 0.0268866 |
| LOX | lysyl oxidase | 0.0261009 |
| UBC | ubiquitin C | 0.0257175 |
| FNBP4 | formin binding protein 4 | 0.0252708 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0250098 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0247526 |
| COPA | coatomer protein complex, subunit alpha | 0.0244423 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0240822 |
| GOLGA4 | golgin A4 | 0.0230556 |
| ADM | adrenomedullin | 0.0224404 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0217958 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0217096 |
| PCBP2 | poly(rC) binding protein 2 | 0.0214019 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0213906 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0213352 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0211463 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0209668 |
| TPM4 | tropomyosin 4 | 0.0208672 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0205745 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0205451 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.020233 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0194726 |
| ENO1 | enolase 1, (alpha) | 0.019367 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0192575 |
| HDLBP | high density lipoprotein binding protein | 0.0191107 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0190008 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0189722 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0187093 |
| AXL | AXL receptor tyrosine kinase | 0.0186376 |
| JUN | jun proto-oncogene | 0.0186366 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0186051 |
| RAB14 | RAB14, member RAS oncogene family | 0.0186037 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0184187 |
| VMP1 | vacuole membrane protein 1 | 0.0183188 |
| RAB18 | RAB18, member RAS oncogene family | 0.0180969 |
| CBX3 | chromobox homolog 3 | 0.0177851 |
| MT2A | metallothionein 2A | 0.0176055 |
| COL5A2 | collagen, type V, alpha 2 | 0.0175975 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0174639 |
| TPI1 | triosephosphate isomerase 1 | 0.0174482 |
| SMIM44 | small integral membrane protein 44 | 0.0174467 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0171733 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0170758 |
| ARF4 | ADP-ribosylation factor 4 | 0.016974 |
| CALU | calumenin | 0.0169168 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0169055 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0168304 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0163253 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0162958 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0162183 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0162121 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0161482 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0159005 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0158956 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0158893 |
| CXXC5 | CXXC finger protein 5 | 0.0158747 |
| MORF4L2 | mortality factor 4 like 2 | 0.015863 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.0158554 |
| MATR3 | matrin 3 | 0.0158357 |
| PGK1 | phosphoglycerate kinase 1 | 0.0156624 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0155375 |
| ITM2B | integral membrane protein 2B | 0.0154916 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0153995 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0152713 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0152578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.179704 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.131635 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.114135 |
| PLAT | plasminogen activator, tissue | -0.112822 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.111683 |
| PODXL | podocalyxin-like | -0.0962144 |
| NDRG1 | N-myc downstream regulated 1 | -0.0896774 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0858341 |
| NAV1 | neuron navigator 1 | -0.0856192 |
| CD44 | CD44 molecule (Indian blood group) | -0.0830342 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0754336 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0724604 |
| NAV2 | neuron navigator 2 | -0.0654086 |
| CDH13 | cadherin 13 | -0.0646603 |
| FLNB | filamin B, beta | -0.0645444 |
| PRELID2 | PRELI domain containing 2 | -0.0638876 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0608417 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0565839 |
| RUNX1 | runt-related transcription factor 1 | -0.056151 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0533433 |
| SEPTIN9 | septin 9 | -0.0495793 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.049101 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0467212 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0447401 |
| COL5A1 | collagen, type V, alpha 1 | -0.0430855 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0425197 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0406095 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0404482 |
| ASPH | aspartate beta-hydroxylase | -0.0403639 |
| SMYD3 | SET and MYND domain containing 3 | -0.0403421 |
| EGFR | epidermal growth factor receptor | -0.0397306 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0396176 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0395348 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0385827 |
| FSTL1 | follistatin-like 1 | -0.0363075 |
| EFNA5 | ephrin-A5 | -0.0350257 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.034725 |
| AUTS2 | autism susceptibility candidate 2 | -0.034715 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0346683 |
| MYOF | myoferlin | -0.0339161 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0337257 |
| HDAC9 | histone deacetylase 9 | -0.0332257 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0329266 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0324556 |
| STC1 | stanniocalcin 1 | -0.032122 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0319289 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0314548 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0314219 |
| CLTC | clathrin, heavy chain (Hc) | -0.0310982 |
| SVIL | supervillin | -0.030769 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0303182 |
| SBF2 | SET binding factor 2 | -0.0297928 |
| DST | dystonin | -0.0293903 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0291893 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0283088 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.028068 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0279727 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0278475 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0277777 |
| CD99 | CD99 molecule | -0.0277352 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.0275086 |
| MTSS1 | metastasis suppressor 1 | -0.0271942 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0270482 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0269509 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0268633 |
| ANKRD11 | ankyrin repeat domain 11 | -0.026525 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0263606 |
| SLC22A23 | solute carrier family 22, member 23 | -0.026298 |
| ADAR | adenosine deaminase, RNA-specific | -0.0261179 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0260969 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0260705 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0260189 |
| PRKCE | protein kinase C, epsilon | -0.0256894 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0254897 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -0.0252866 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0249915 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0249329 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0247307 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0244287 |
| STK10 | serine/threonine kinase 10 | -0.0243401 |
| MYO9B | myosin IXB | -0.024141 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0239589 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0238874 |
| RPL37A | ribosomal protein L37a | -0.0237756 |
| TDRD7 | tudor domain containing 7 | -0.0234875 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0234836 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0233987 |
| OSMR | oncostatin M receptor | -0.0233764 |
| S100A10 | S100 calcium binding protein A10 | -0.0230875 |
| ARFGEF3 | ARFGEF family member 3 | -0.0230493 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0229458 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0228161 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0228025 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0227248 |
| ATP13A3 | ATPase type 13A3 | -0.0226558 |
| FAM219A | family with sequence similarity 219, member A | -0.0224488 |
| MSN | moesin | -0.0223791 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0223286 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0223117 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0221399 |
