Neratinib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.134978
HMGA2 high mobility group AT-hook 2 0.128921
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.100431
EHBP1 EH domain binding protein 1 0.078775
NLGN1 neuroligin 1 0.0741246
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0699012
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.059174
YAP1 Yes-associated protein 1 0.0556219
INTS6 integrator complex subunit 6 0.053183
DPYD dihydropyrimidine dehydrogenase 0.0487006
ASPH aspartate beta-hydroxylase 0.043476
ADIPOR2 adiponectin receptor 2 0.0415244
EGR1 early growth response 1 0.0403888
ZNF804A zinc finger protein 804A 0.0403186
MSRB3 methionine sulfoxide reductase B3 0.0399466
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0380493
PCBP2 poly(rC) binding protein 2 0.0374844
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0366023
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0358662
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0344296
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0333513
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0328443
CENPF centromere protein F, 350/400kDa 0.0320903
RAB7A RAB7A, member RAS oncogene family 0.0318777
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0313623
POTEF POTE ankyrin domain family, member F 0.0313209
NHSL1 NHS-like 1 0.0304725
DST dystonin 0.0301577
CCN2 cellular communication network factor 2 0.0301227
CSMD3 CUB and Sushi multiple domains 3 0.0296199
ANKRD17 ankyrin repeat domain 17 0.029471
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0293686
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0285596
CUX1 cut-like homeobox 1 0.0284673
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0282482
ZSWIM6 zinc finger, SWIM-type containing 6 0.0276291
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0270861
NAV3 neuron navigator 3 0.027018
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0261995
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0261922
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0261747
ASXL1 additional sex combs like transcriptional regulator 1 0.0260135
TUBA1B tubulin, alpha 1b 0.0257919
CARD16 caspase recruitment domain family, member 16 0.0257415
RASAL2 RAS protein activator like 2 0.0256136
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0252163
FSTL5 follistatin-like 5 0.0248027
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.02463
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0245638
LPP LIM domain containing preferred translocation partner in lipoma 0.024421
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0242702
SKIL SKI-like proto-oncogene 0.0232834
MACF1 microtubule-actin crosslinking factor 1 0.0232736
VMP1 vacuole membrane protein 1 0.0229457
PCDH9 protocadherin 9 0.022843
HDGF hepatoma-derived growth factor 0.0227868
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0224508
SYT1 synaptotagmin I 0.0219973
ANXA1 annexin A1 0.0218233
PACS1 phosphofurin acidic cluster sorting protein 1 0.0214944
TPM3 tropomyosin 3 0.0210288
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0204603
EXOC4 exocyst complex component 4 0.0204493
RCOR1 REST corepressor 1 0.0201809
MARCHF4 membrane associated ring-CH-type finger 4 0.0201802
LRRC23 leucine rich repeat containing 23 0.0201145
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0200254
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0197515
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0196903
DENND5A DENN/MADD domain containing 5A 0.0196533
CCSER1 coiled-coil serine-rich protein 1 0.0193121
TPM4 tropomyosin 4 0.0192825
DOCK1 dedicator of cytokinesis 1 0.0188714
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0188337
NEBL nebulette 0.0187891
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0187699
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0187164
SRRM2 serine/arginine repetitive matrix 2 0.0187104
PRH1 proline-rich protein HaeIII subfamily 1 0.0184474
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.018438
KDM4C lysine (K)-specific demethylase 4C 0.0181188
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0179904
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0179708
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0179641
ASXL2 additional sex combs like transcriptional regulator 2 0.0177287
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0175167
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0174661
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0174634
STAU2 staufen double-stranded RNA binding protein 2 0.0174126
TTC27 tetratricopeptide repeat domain 27 0.0173502
EPHA5 EPH receptor A5 0.017332
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0172246
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0172176
PHACTR4 phosphatase and actin regulator 4 0.0171626
JMJD1C jumonji domain containing 1C 0.0170335
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0170302
TTC3 tetratricopeptide repeat domain 3 0.0169453
MYADM myeloid-associated differentiation marker 0.0168273
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0164875
STXBP4 syntaxin binding protein 4 0.0164535

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.368257
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149455
TMSB10 thymosin beta 10 -0.0963333
AREG amphiregulin -0.0581921
RPS27A ribosomal protein S27a -0.0526594
CELF2 CUGBP, Elav-like family member 2 -0.0511372
MYL12B myosin, light chain 12B, regulatory -0.0501793
CXADR coxsackie virus and adenovirus receptor -0.0490089
TXNRD1 thioredoxin reductase 1 -0.0476567
ANKRD12 ankyrin repeat domain 12 -0.0419601
RPL23 ribosomal protein L23 -0.0417603
RPLP1 ribosomal protein, large, P1 -0.0409735
FUS FUS RNA binding protein -0.0403085
NEK7 NIMA-related kinase 7 -0.0396877
AHNAK AHNAK nucleoprotein -0.0389101
TPT1 tumor protein, translationally-controlled 1 -0.037811
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0377498
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0375016
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0354691
TMEM41B transmembrane protein 41B -0.0354128
PDE4D phosphodiesterase 4D, cAMP-specific -0.0351686
KLHL24 kelch-like family member 24 -0.0350644
RPS24 ribosomal protein S24 -0.0349534
RPL34 ribosomal protein L34 -0.0345342
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0339668
KDM3A lysine (K)-specific demethylase 3A -0.033912
MGAT4C MGAT4 family, member C -0.0337949
MARCHF6 membrane associated ring-CH-type finger 6 -0.0329308
ZNF217 zinc finger protein 217 -0.0321068
RPL26 ribosomal protein L26 -0.0313705
RPL12 ribosomal protein L12 -0.0312062
RPL11 ribosomal protein L11 -0.0311594
UBC ubiquitin C -0.0303543
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0301446
RPS21 ribosomal protein S21 -0.0298662
CEP95 centrosomal protein 95kDa -0.0293923
KLF6 Kruppel-like factor 6 -0.0292405
ADGRG6 adhesion G protein-coupled receptor G6 -0.0282172
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0277716
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0273228
RPL35A ribosomal protein L35a -0.0272096
RPL38 ribosomal protein L38 -0.0271981
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0264398
ZNF292 zinc finger protein 292 -0.0263162
RPS6 ribosomal protein S6 -0.0258724
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0254347
EEF2 eukaryotic translation elongation factor 2 -0.0251333
TMEM123 transmembrane protein 123 -0.0249947
ZBTB20 zinc finger and BTB domain containing 20 -0.0245077
TGIF1 TGFB-induced factor homeobox 1 -0.0235667
SEPTIN7 septin 7 -0.0235006
RB1CC1 RB1-inducible coiled-coil 1 -0.0234797
TNPO1 transportin 1 -0.0234018
OGA O-GlcNAcase -0.0233121
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0231776
YBX1 Y box binding protein 1 -0.022852
RPLP2 ribosomal protein, large, P2 -0.022733
RPL5 ribosomal protein L5 -0.0222933
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0221379
RPL19 ribosomal protein L19 -0.0220411
CNRIP1 cannabinoid receptor interacting protein 1 -0.0220342
H1-0 H1.0 linker histone -0.0219616
RPL32 ribosomal protein L32 -0.0217648
RPL4 ribosomal protein L4 -0.0213043
BRWD3 bromodomain and WD repeat domain containing 3 -0.0212442
CEP192 centrosomal protein 192kDa -0.0210567
THOC1 THO complex 1 -0.0208138
ADAM17 ADAM metallopeptidase domain 17 -0.0207317
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0206897
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0206891
RPL8 ribosomal protein L8 -0.0204471
RPL9 ribosomal protein L9 -0.0204321
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0204133
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0202771
LMO7 LIM domain 7 -0.020061
GASK1B golgi associated kinase 1B -0.0200295
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0199652
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0199182
ATP11A ATPase, class VI, type 11A -0.0198931
WDR45B WD repeat domain 45B -0.0194768
WSB1 WD repeat and SOCS box containing 1 -0.0194583
PCNP PEST proteolytic signal containing nuclear protein -0.019435
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0192375
OXR1 oxidation resistance 1 -0.0191651
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0186558
ATP5F1B ATP synthase F1 subunit beta -0.0184322
FBXL2 F-box and leucine-rich repeat protein 2 -0.0182683
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0181602
YBX3 Y box binding protein 3 -0.0177461
CAMTA1 calmodulin binding transcription activator 1 -0.0177426
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0174227
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0173607
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0172593
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.017231
PDE4B phosphodiesterase 4B, cAMP-specific -0.0172001
RBM27 RNA binding motif protein 27 -0.0169246
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.016796
RAD21 RAD21 homolog (S. pombe) -0.0167787
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0167476
RPS29 ribosomal protein S29 -0.0166358