Neratinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.314222
LSAMP limbic system-associated membrane protein 0.105559
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0787817
SYT1 synaptotagmin I 0.0747036
MSI2 musashi RNA-binding protein 2 0.0694697
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0650262
PCBP2 poly(rC) binding protein 2 0.0567637
ANGPT1 angiopoietin 1 0.0553318
SOS1 son of sevenless homolog 1 (Drosophila) 0.0533393
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0524981
NCAM2 neural cell adhesion molecule 2 0.0507137
PTPRK protein tyrosine phosphatase, receptor type, K 0.0480813
TPST1 tyrosylprotein sulfotransferase 1 0.0477858
MEIS2 Meis homeobox 2 0.0468636
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0461778
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.045388
PLPP1 phospholipid phosphatase 1 0.0427066
PDE4D phosphodiesterase 4D, cAMP-specific 0.0416589
BPTF bromodomain PHD finger transcription factor 0.0399556
MAPK10 mitogen-activated protein kinase 10 0.0392072
B2M beta-2-microglobulin 0.0388614
COL3A1 collagen, type III, alpha 1 0.0388321
TULP4 tubby like protein 4 0.0376011
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0371836
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0370662
CRH corticotropin releasing hormone 0.0370249
SETD5 SET domain containing 5 0.0370187
SMYD3 SET and MYND domain containing 3 0.0369405
SLITRK6 SLIT and NTRK-like family, member 6 0.0366964
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0356963
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0349314
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0348361
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0348022
PTPRD protein tyrosine phosphatase, receptor type, D 0.0346723
LPIN1 lipin 1 0.034506
JMJD1C jumonji domain containing 1C 0.0342344
MBD5 methyl-CpG binding domain protein 5 0.0340529
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0335138
TENT5A terminal nucleotidyltransferase 5A 0.0333681
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0327994
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0317241
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0313569
WDR43 WD repeat domain 43 0.0312181
CHD9 chromodomain helicase DNA binding protein 9 0.0303801
NALF1 NALCN channel auxiliary factor 1 0.0302439
ZCCHC7 zinc finger, CCHC domain containing 7 0.030022
ZNF804A zinc finger protein 804A 0.0299062
MRTFA myocardin related transcription factor A 0.0294153
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0287938
PABPC1 poly(A) binding protein, cytoplasmic 1 0.028456
CADM2 cell adhesion molecule 2 0.0284169
ANTXR1 anthrax toxin receptor 1 0.0282308
PRKCA protein kinase C, alpha 0.0280399
MAP1B microtubule-associated protein 1B 0.0280114
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.027857
GPC5 glypican 5 0.0274985
COL4A5 collagen, type IV, alpha 5 0.0274292
ZFC3H1 zinc finger, C3H1-type containing 0.0271282
ARHGAP9 Rho GTPase activating protein 9 0.0270101
GRK5 G protein-coupled receptor kinase 5 0.0269049
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0267588
RHOBTB3 Rho-related BTB domain containing 3 0.0265487
PRRC2C proline-rich coiled-coil 2C 0.0263773
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.025982
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.02598
RCOR3 REST corepressor 3 0.0259013
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0258928
TLK2 tousled-like kinase 2 0.0258924
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0257549
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0257482
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.025639
UBE2K ubiquitin-conjugating enzyme E2K 0.0255661
ITPRID2 ITPR interacting domain containing 2 0.0255341
WAC WW domain containing adaptor with coiled-coil 0.0254985
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0254853
KIDINS220 kinase D-interacting substrate, 220kDa 0.0254841
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0254246
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0253732
EXT1 exostosin glycosyltransferase 1 0.02537
KAT6A K(lysine) acetyltransferase 6A 0.0252675
DLC1 DLC1 Rho GTPase activating protein 0.0252566
CLTC clathrin, heavy chain (Hc) 0.0251411
CEP350 centrosomal protein 350kDa 0.0250273
FBXW11 F-box and WD repeat domain containing 11 0.0249276
ANKRD17 ankyrin repeat domain 17 0.0249152
ATRNL1 attractin-like 1 0.0247508
BRWD1 bromodomain and WD repeat domain containing 1 0.0244501
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0244481
CPED1 cadherin-like and PC-esterase domain containing 1 0.0242675
MED13L mediator complex subunit 13-like 0.0240348
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0239919
LIMCH1 LIM and calponin homology domains 1 0.0238954
RBM26 RNA binding motif protein 26 0.0238063
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0235043
DPH6 diphthamine biosynthesis 6 0.0230308
MON2 MON2 homolog (S. cerevisiae) 0.0229686
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0229645
NKTR natural killer cell triggering receptor 0.0229576
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0228899
COPA coatomer protein complex, subunit alpha 0.0228826

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.179191
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118681
VIM vimentin -0.0641323
RPS6 ribosomal protein S6 -0.0536485
RPLP1 ribosomal protein, large, P1 -0.0483473
TMSB10 thymosin beta 10 -0.0483408
AKAP12 A kinase (PRKA) anchor protein 12 -0.0463018
RPS12 ribosomal protein S12 -0.045478
CEMIP cell migration inducing protein, hyaluronan binding -0.0427836
ACTG1 actin gamma 1 -0.040913
RPL38 ribosomal protein L38 -0.0406269
RPL34 ribosomal protein L34 -0.0395271
NDRG1 N-myc downstream regulated 1 -0.0368059
RPL35A ribosomal protein L35a -0.0365382
RPL23 ribosomal protein L23 -0.0362007
FAM13A family with sequence similarity 13, member A -0.0344296
RPL27 ribosomal protein L27 -0.0338639
EGR1 early growth response 1 -0.0337746
RPS19 ribosomal protein S19 -0.0334606
TPT1 tumor protein, translationally-controlled 1 -0.0328004
HMGB2 high mobility group box 2 -0.0323306
GNAS GNAS complex locus -0.0302291
HILPDA hypoxia inducible lipid droplet-associated -0.0297249
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0286411
RPL26 ribosomal protein L26 -0.0283196
TPI1 triosephosphate isomerase 1 -0.0280262
VCL vinculin -0.0277488
NRG1 neuregulin 1 -0.0273152
FLT1 fms-related tyrosine kinase 1 -0.0273118
RHOB ras homolog family member B -0.0265138
RPS24 ribosomal protein S24 -0.0263677
PCBP3 poly(rC) binding protein 3 -0.0261777
S100A6 S100 calcium binding protein A6 -0.0260453
MEF2A myocyte enhancer factor 2A -0.0257364
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0250023
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0249917
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0247752
EPAS1 endothelial PAS domain protein 1 -0.0246716
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0246701
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0245887
MACF1 microtubule-actin crosslinking factor 1 -0.0245836
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0245144
S100A9 S100 calcium binding protein A9 -0.0243667
RPL37 ribosomal protein L37 -0.0239633
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0237449
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0236038
RPS13 ribosomal protein S13 -0.0228781
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0228499
RPL9 ribosomal protein L9 -0.0228353
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.022777
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0227703
KLF6 Kruppel-like factor 6 -0.0225653
STC1 stanniocalcin 1 -0.022557
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0224695
SOX9 SRY (sex determining region Y)-box 9 -0.022305
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0219858
RPL35 ribosomal protein L35 -0.0218946
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0217293
MCL1 myeloid cell leukemia 1 -0.021598
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0215277
ZNF292 zinc finger protein 292 -0.0211898
RPL31 ribosomal protein L31 -0.0207225
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0205552
EZR ezrin -0.0205258
ANKRD11 ankyrin repeat domain 11 -0.0201603
RNF213 ring finger protein 213 -0.0200681
IER3 immediate early response 3 -0.0200603
ELL2 elongation factor, RNA polymerase II, 2 -0.0200249
UBE2H ubiquitin-conjugating enzyme E2H -0.0199651
PFN1 profilin 1 -0.0199292
PTMA prothymosin, alpha -0.01972
RPL19 ribosomal protein L19 -0.0195663
RPS17 ribosomal protein S17 -0.019468
C1ORF21 chromosome 1 open reading frame 21 -0.0184228
WSB1 WD repeat and SOCS box containing 1 -0.0182952
VEGFA vascular endothelial growth factor A -0.0182155
RPS27 ribosomal protein S27 -0.0181111
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0180197
RPL32 ribosomal protein L32 -0.0180117
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0179467
FLNB filamin B, beta -0.0177088
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0176648
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0175198
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0174111
YME1L1 YME1-like 1 ATPase -0.017231
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0171735
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0170762
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0166479
NAP1L1 nucleosome assembly protein 1-like 1 -0.0166137
SSH1 slingshot protein phosphatase 1 -0.0164752
RPL5 ribosomal protein L5 -0.0164014
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0163459
RPL36 ribosomal protein L36 -0.0162737
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0161403
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0160967
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0160654
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0160512
TPR translocated promoter region, nuclear basket protein -0.0160427
KLC1 kinesin light chain 1 -0.0159533
PLAT plasminogen activator, tissue -0.0159504