Neratinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNIP thioredoxin interacting protein 0.0826898
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0817137
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.074949
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0700044
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0687285
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0586199
PHF3 PHD finger protein 3 0.0569993
SPATA13 spermatogenesis associated 13 0.0556227
ABHD2 abhydrolase domain containing 2 0.0533224
ARHGAP26 Rho GTPase activating protein 26 0.049498
TRIO trio Rho guanine nucleotide exchange factor 0.0485769
PTBP3 polypyrimidine tract binding protein 3 0.0481563
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0476783
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0464634
ITGA6 integrin, alpha 6 0.0460297
VMP1 vacuole membrane protein 1 0.0456704
FAT1 FAT atypical cadherin 1 0.0398531
ATP11A ATPase, class VI, type 11A 0.0379509
ANKRD17 ankyrin repeat domain 17 0.0376137
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0369627
CD46 CD46 molecule, complement regulatory protein 0.0368357
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.033393
MBD5 methyl-CpG binding domain protein 5 0.0332806
BCLAF1 BCL2-associated transcription factor 1 0.0332673
ARHGAP5 Rho GTPase activating protein 5 0.0329515
MACC1 metastasis associated in colon cancer 1 0.0320137
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0318241
GMDS GDP-mannose 4,6-dehydratase 0.0314869
MKI67 marker of proliferation Ki-67 0.0314204
RBM39 RNA binding motif protein 39 0.0298772
SAMD12 sterile alpha motif domain containing 12 0.0289601
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.028214
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0281245
NKD1 naked cuticle homolog 1 (Drosophila) 0.0280704
ZMYND8 zinc finger, MYND-type containing 8 0.0280054
TMEM87A transmembrane protein 87A 0.0276388
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.027419
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.027275
RUNX1 runt-related transcription factor 1 0.0270792
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0262981
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0257996
ERBIN erbb2 interacting protein 0.0256608
CCDC146 coiled-coil domain containing 146 0.0256344
AHI1 Abelson helper integration site 1 0.0254831
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0253433
RNF149 ring finger protein 149 0.0252216
DSPP dentin sialophosphoprotein 0.0251167
KLF3 Kruppel-like factor 3 (basic) 0.0249135
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0246265
STK24 serine/threonine kinase 24 0.0245743
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0245617
IL20RA interleukin 20 receptor, alpha 0.0244222
ZDHHC20 zinc finger, DHHC-type containing 20 0.0241959
CENPF centromere protein F, 350/400kDa 0.0241304
RBM25 RNA binding motif protein 25 0.0240737
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.023972
EPSTI1 epithelial stromal interaction 1 (breast) 0.0233124
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0231443
CUX1 cut-like homeobox 1 0.0228542
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0228388
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0226873
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0226543
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0226445
JAK1 Janus kinase 1 0.0226409
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0221544
SACK1B scaffolding CK1 anchoring protein B 0.021868
LYZ lysozyme 0.0218393
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0218188
PROX1 prospero homeobox 1 0.0217973
IGF1R insulin-like growth factor 1 receptor 0.0216311
PATJ PATJ crumbs cell polarity complex component 0.0216046
NDFIP2 Nedd4 family interacting protein 2 0.0212617
LIMA1 LIM domain and actin binding 1 0.0210529
TMEM123 transmembrane protein 123 0.0209269
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0208562
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0206982
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0206625
HDAC8 histone deacetylase 8 0.0206194
TMC5 transmembrane channel-like 5 0.0205851
EPHB2 EPH receptor B2 0.0205654
LPP LIM domain containing preferred translocation partner in lipoma 0.0204861
MED13 mediator complex subunit 13 0.0204672
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.020446
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.020246
TUFT1 tuftelin 1 0.0201935
RAD51B RAD51 paralog B 0.0199823
GOLM2 golgi membrane protein 2 0.0197048
PANK3 pantothenate kinase 3 0.0195419
RHOBTB3 Rho-related BTB domain containing 3 0.0193505
TNXB tenascin XB 0.0190785
SORBS1 sorbin and SH3 domain containing 1 0.0190454
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0190333
DYM dymeclin 0.0190225
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0189681
C6ORF62 chromosome 6 open reading frame 62 0.0189494
SH3RF1 SH3 domain containing ring finger 1 0.0189297
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.0187215
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0184849
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0182832
LDHA lactate dehydrogenase A 0.01825

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.150494
LMO7 LIM domain 7 -0.110369
GCLC glutamate-cysteine ligase, catalytic subunit -0.105752
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.099034
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0915421
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0909409
EZR ezrin -0.0770403
FTH1 ferritin, heavy polypeptide 1 -0.070545
ANXA2 annexin A2 -0.0684784
RPS6 ribosomal protein S6 -0.0677669
MBNL2 muscleblind-like splicing regulator 2 -0.0579383
RAB7A RAB7A, member RAS oncogene family -0.0555966
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0555134
RPLP1 ribosomal protein, large, P1 -0.0540481
FNDC3B fibronectin type III domain containing 3B -0.053699
EGR1 early growth response 1 -0.0534381
RPL35A ribosomal protein L35a -0.0531638
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0524537
RPL23 ribosomal protein L23 -0.0504092
IFI6 interferon, alpha-inducible protein 6 -0.0500976
RPL34 ribosomal protein L34 -0.0481265
RPL19 ribosomal protein L19 -0.0471044
TMSB10 thymosin beta 10 -0.0451772
UBC ubiquitin C -0.0417713
EIF1 eukaryotic translation initiation factor 1 -0.041333
XAF1 XIAP associated factor 1 -0.0409766
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0404002
SEC31A SEC31 homolog A (S. cerevisiae) -0.0399282
RPS19 ribosomal protein S19 -0.0397446
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0394647
TRERF1 transcriptional regulating factor 1 -0.037586
NDRG1 N-myc downstream regulated 1 -0.0372661
LOC112694756 uncharaterized LOC112694756 -0.0365422
TBC1D22A TBC1 domain family, member 22A -0.036533
HLA-B major histocompatibility complex, class I, B -0.0362511
RNF213 ring finger protein 213 -0.03576
RPL37A ribosomal protein L37a -0.0350167
RPS24 ribosomal protein S24 -0.0349419
BLZF1 basic leucine zipper nuclear factor 1 -0.0344472
SLC38A1 solute carrier family 38, member 1 -0.0344415
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0341423
ATF4 activating transcription factor 4 -0.0339527
RPL12 ribosomal protein L12 -0.0338791
RPS27 ribosomal protein S27 -0.0337711
WSB1 WD repeat and SOCS box containing 1 -0.0335031
FTL ferritin, light polypeptide -0.0330214
S100A10 S100 calcium binding protein A10 -0.0330138
RPL26 ribosomal protein L26 -0.0326443
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0319862
AHNAK AHNAK nucleoprotein -0.0316082
NCKAP5 NCK-associated protein 5 -0.0315967
RPL11 ribosomal protein L11 -0.0313411
RPS8 ribosomal protein S8 -0.0310096
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0306487
MUC20 mucin 20, cell surface associated -0.0302086
INTS6 integrator complex subunit 6 -0.0299453
S100P S100 calcium binding protein P -0.0298668
LCN2 lipocalin 2 -0.0296708
SUCO SUN domain containing ossification factor -0.0293503
RSF1 remodeling and spacing factor 1 -0.028962
C6ORF132 chromosome 6 open reading frame 132 -0.028578
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0281789
IRF1 interferon regulatory factor 1 -0.0281301
RPS3 ribosomal protein S3 -0.0279564
HLA-C major histocompatibility complex, class I, C -0.0278522
RPS17 ribosomal protein S17 -0.0277548
MT2A metallothionein 2A -0.0275672
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0271009
MORF4L2 mortality factor 4 like 2 -0.0268851
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0261754
PHACTR4 phosphatase and actin regulator 4 -0.0260225
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0259308
UGDH UDP-glucose 6-dehydrogenase -0.0257603
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0256626
IRS2 insulin receptor substrate 2 -0.0256582
HM13 histocompatibility (minor) 13 -0.0256368
FRMD5 FERM domain containing 5 -0.0255287
PDIA3 protein disulfide isomerase family A, member 3 -0.0254922
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0254819
GCC2 GRIP and coiled-coil domain containing 2 -0.0253977
SDC4 syndecan 4 -0.025242
KRT8 keratin 8, type II -0.0251119
TJP1 tight junction protein 1 -0.0248544
KLF6 Kruppel-like factor 6 -0.0247972
LMNA lamin A/C -0.0245924
EFNB2 ephrin-B2 -0.0245609
RACK1 receptor for activated C kinase 1 -0.0244605
RPL31 ribosomal protein L31 -0.0244227
PDLIM5 PDZ and LIM domain 5 -0.0243689
ANXA1 annexin A1 -0.0242396
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0241665
AREG amphiregulin -0.024108
STX5 syntaxin 5 -0.0240932
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0240925
RPL38 ribosomal protein L38 -0.0240244
ISG15 ISG15 ubiquitin-like modifier -0.0239425
HKDC1 hexokinase domain containing 1 -0.0239404
IFI27 interferon, alpha-inducible protein 27 -0.0238215
MCL1 myeloid cell leukemia 1 -0.0237991
ZNF207 zinc finger protein 207 -0.0236476