| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.325604 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.231991 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.168955 |
| VEGFA | vascular endothelial growth factor A | 0.090339 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0857691 |
| VCAN | versican | 0.0681568 |
| COL1A2 | collagen, type I, alpha 2 | 0.0570762 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0450541 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0425821 |
| B2M | beta-2-microglobulin | 0.041128 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0384464 |
| STC1 | stanniocalcin 1 | 0.0367903 |
| MSN | moesin | 0.0351983 |
| POTEF | POTE ankyrin domain family, member F | 0.0341088 |
| AXL | AXL receptor tyrosine kinase | 0.0341 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0325387 |
| FBN1 | fibrillin 1 | 0.0312712 |
| TMF1 | TATA element modulatory factor 1 | 0.0304198 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0300134 |
| TMEM165 | transmembrane protein 165 | 0.0298978 |
| LDHA | lactate dehydrogenase A | 0.0293688 |
| DSTN | destrin (actin depolymerizing factor) | 0.0293419 |
| VMP1 | vacuole membrane protein 1 | 0.0288472 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0275561 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0272016 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0266705 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0262441 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0234365 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0234343 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0220978 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0218095 |
| TPM4 | tropomyosin 4 | 0.0209369 |
| BRD2 | bromodomain containing 2 | 0.0208499 |
| ARF4 | ADP-ribosylation factor 4 | 0.0204973 |
| MLEC | malectin | 0.0203975 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0200829 |
| HYOU1 | hypoxia up-regulated 1 | 0.0199144 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0198734 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0193079 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0192389 |
| LAMB1 | laminin, beta 1 | 0.0191361 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0188444 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0186239 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0183654 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0181145 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.0180723 |
| MYADM | myeloid-associated differentiation marker | 0.0176728 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0176717 |
| STC2 | stanniocalcin 2 | 0.0176476 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0175566 |
| CALD1 | caldesmon 1 | 0.0174218 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0173631 |
| SQLE | squalene epoxidase | 0.0172856 |
| CLU | clusterin | 0.0171243 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0168003 |
| PCBP2 | poly(rC) binding protein 2 | 0.0165588 |
| NBAS | neuroblastoma amplified sequence | 0.0163755 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0160195 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0159541 |
| TPM3 | tropomyosin 3 | 0.0158135 |
| WASF2 | WAS protein family, member 2 | 0.0157989 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0157856 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0157181 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0156583 |
| CCN2 | cellular communication network factor 2 | 0.0156069 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0155694 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0153305 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0152757 |
| AMOTL1 | angiomotin like 1 | 0.0149881 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0146904 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0145934 |
| NUCB2 | nucleobindin 2 | 0.0145204 |
| LIMA1 | LIM domain and actin binding 1 | 0.0144737 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0143243 |
| COG6 | component of oligomeric golgi complex 6 | 0.0143036 |
| MYO10 | myosin X | 0.0142 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0139447 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0136814 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0131705 |
| TPM1 | tropomyosin 1 (alpha) | 0.0131635 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0130356 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0130096 |
| POSTN | periostin, osteoblast specific factor | 0.0129979 |
| FOSL1 | FOS-like antigen 1 | 0.0129743 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0128477 |
| ZNF146 | zinc finger protein 146 | 0.0128284 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0127456 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0126694 |
| IFT80 | intraflagellar transport 80 | 0.0125501 |
| TAGLN2 | transgelin 2 | 0.0125015 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.012438 |
| OXR1 | oxidation resistance 1 | 0.0124215 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0123219 |
| TUBA1B | tubulin, alpha 1b | 0.0120794 |
| CENPF | centromere protein F, 350/400kDa | 0.0120333 |
| SSRP1 | structure specific recognition protein 1 | 0.0119898 |
| SRP54 | signal recognition particle 54kDa | 0.011969 |
| TPX2 | TPX2, microtubule-associated | 0.0118131 |
| CCDC14 | coiled-coil domain containing 14 | 0.0117007 |
| HEATR5A | HEAT repeat containing 5A | 0.0116391 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.269262 |
| VIM | vimentin | -0.241903 |
| NDRG1 | N-myc downstream regulated 1 | -0.123496 |
| COL1A1 | collagen, type I, alpha 1 | -0.120479 |
| FN1 | fibronectin 1 | -0.104376 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.102268 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0962502 |
| CD44 | CD44 molecule (Indian blood group) | -0.086087 |
| TMSB10 | thymosin beta 10 | -0.0787364 |
| CDH13 | cadherin 13 | -0.0751383 |
| IER3 | immediate early response 3 | -0.0735665 |
| RPL35A | ribosomal protein L35a | -0.0676806 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.064839 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0642284 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0591091 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0527101 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0505592 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0480821 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0472487 |
| PDE10A | phosphodiesterase 10A | -0.047165 |
| AHNAK | AHNAK nucleoprotein | -0.0471332 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0437796 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0428489 |
| PRELID2 | PRELI domain containing 2 | -0.0427955 |
| RPS8 | ribosomal protein S8 | -0.0422663 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0410695 |
| RIGI | RNA sensor RIG-I | -0.0401362 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0367581 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0364558 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0364352 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0359171 |
| RPL11 | ribosomal protein L11 | -0.0350344 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0347644 |
| TMSB4X | thymosin beta 4, X-linked | -0.0339353 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0335252 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0331428 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0329729 |
| CADM1 | cell adhesion molecule 1 | -0.0329478 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0321096 |
| RPL23 | ribosomal protein L23 | -0.031545 |
| ANXA2 | annexin A2 | -0.0315355 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0297054 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0296092 |
| OSMR | oncostatin M receptor | -0.0293833 |
| HLA-B | major histocompatibility complex, class I, B | -0.0288352 |
| MAP4 | microtubule-associated protein 4 | -0.028796 |
| OGA | O-GlcNAcase | -0.0287415 |
| RPL26 | ribosomal protein L26 | -0.0281038 |
| RPL30 | ribosomal protein L30 | -0.027745 |
| RPLP1 | ribosomal protein, large, P1 | -0.0271489 |
| RPL34 | ribosomal protein L34 | -0.027125 |
| SPAG9 | sperm associated antigen 9 | -0.0267635 |
| NAV2 | neuron navigator 2 | -0.026594 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0264195 |
| SP100 | SP100 nuclear antigen | -0.0263179 |
| RND3 | Rho family GTPase 3 | -0.0259554 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0259185 |
| COL5A1 | collagen, type V, alpha 1 | -0.0258941 |
| RBM39 | RNA binding motif protein 39 | -0.0255478 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0254094 |
| HIP1 | huntingtin interacting protein 1 | -0.0249461 |
| FMNL2 | formin-like 2 | -0.0249396 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0249017 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0248189 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246985 |
| ZNF292 | zinc finger protein 292 | -0.0245197 |
| COL3A1 | collagen, type III, alpha 1 | -0.0243266 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0242628 |
| RPS3 | ribosomal protein S3 | -0.02425 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0241332 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0237071 |
| RPL7 | ribosomal protein L7 | -0.0235893 |
| RPL12 | ribosomal protein L12 | -0.0229664 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0227205 |
| RPS6 | ribosomal protein S6 | -0.0225245 |
| RACK1 | receptor for activated C kinase 1 | -0.0224221 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0222331 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0221659 |
| APP | amyloid beta (A4) precursor protein | -0.0220222 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0218527 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.021578 |
| RPL8 | ribosomal protein L8 | -0.0215525 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0213741 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0210475 |
| RPS24 | ribosomal protein S24 | -0.0208843 |
| LMNA | lamin A/C | -0.0206884 |
| STK10 | serine/threonine kinase 10 | -0.0206545 |
| RPL32 | ribosomal protein L32 | -0.0205784 |
| MT2A | metallothionein 2A | -0.0204468 |
| RPL5 | ribosomal protein L5 | -0.0202647 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0202602 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0202542 |
| RPL19 | ribosomal protein L19 | -0.0202061 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0201197 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0199166 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0198267 |
| CAVIN1 | caveolae associated protein 1 | -0.0196796 |
| SRGN | serglycin | -0.0196777 |
| KLF6 | Kruppel-like factor 6 | -0.0196267 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0196151 |
