Neratinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.163724
CPE carboxypeptidase E 0.0694919
VMP1 vacuole membrane protein 1 0.0689288
FBF1 Fas (TNFRSF6) binding factor 1 0.0684282
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0649786
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0622595
TF transferrin 0.0615552
APLP2 amyloid beta (A4) precursor-like protein 2 0.0542899
PCBP2 poly(rC) binding protein 2 0.0537329
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0528139
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0473675
PEG10 paternally expressed 10 0.0460925
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0459058
VEGFA vascular endothelial growth factor A 0.0442334
RPS12 ribosomal protein S12 0.0405629
FAM107B family with sequence similarity 107, member B 0.0387329
WDR43 WD repeat domain 43 0.0382376
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0364388
TNS1 tensin 1 0.0340232
GPC6 glypican 6 0.0339909
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0333254
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0332551
ITGAV integrin, alpha V 0.0330737
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.031143
DSPP dentin sialophosphoprotein 0.0309761
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0303437
PTPRM protein tyrosine phosphatase, receptor type, M 0.0300811
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0298234
EIF4B eukaryotic translation initiation factor 4B 0.0286434
EEF2 eukaryotic translation elongation factor 2 0.0274366
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0274116
NKD1 naked cuticle homolog 1 (Drosophila) 0.027111
RPL3 ribosomal protein L3 0.0270011
AHSG alpha-2-HS-glycoprotein 0.0269904
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0268313
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0264272
TCIM transcriptional and immune response regulator 0.0261771
PDLIM5 PDZ and LIM domain 5 0.0261247
MAML2 mastermind-like 2 (Drosophila) 0.0259231
BCL2L1 BCL2-like 1 0.0257193
KTN1 kinectin 1 (kinesin receptor) 0.0256574
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0247649
ARHGAP9 Rho GTPase activating protein 9 0.0241092
SET SET nuclear proto-oncogene 0.0239864
ASXL1 additional sex combs like transcriptional regulator 1 0.0235504
TNS3 tensin 3 0.0231933
DNAH17 dynein, axonemal, heavy chain 17 0.0230591
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0230292
SEPTIN9 septin 9 0.023017
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0225007
NCOA2 nuclear receptor coactivator 2 0.0221287
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.022028
NFE2L1 nuclear factor, erythroid 2-like 1 0.021882
PACS1 phosphofurin acidic cluster sorting protein 1 0.0216083
LMCD1 LIM and cysteine-rich domains 1 0.0210862
SELENOP selenoprotein P 0.0209674
CALD1 caldesmon 1 0.0208987
CCNY cyclin Y 0.0208643
ZEB1 zinc finger E-box binding homeobox 1 0.0208364
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0206859
LCOR ligand dependent nuclear receptor corepressor 0.0206042
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0204285
EGR1 early growth response 1 0.0201632
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.019569
CRY1 cryptochrome circadian clock 1 0.0195049
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0194872
SCN1A sodium channel, voltage gated, type I alpha subunit 0.0194521
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0192024
MAPK1 mitogen-activated protein kinase 1 0.0191355
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0187498
PICALM phosphatidylinositol binding clathrin assembly protein 0.0186309
EHBP1 EH domain binding protein 1 0.018612
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0186105
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.018044
MATN3 matrilin 3 0.017997
FLNB filamin B, beta 0.0179713
CCN2 cellular communication network factor 2 0.0179248
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0178981
FILIP1L filamin A interacting protein 1-like 0.0178746
COL27A1 collagen, type XXVII, alpha 1 0.0177998
ADIPOR2 adiponectin receptor 2 0.0177826
EIF5B eukaryotic translation initiation factor 5B 0.0174577
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0172098
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0170678
BCLAF1 BCL2-associated transcription factor 1 0.0169525
ZFP36L1 ZFP36 ring finger protein-like 1 0.0169105
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0168481
RPS7 ribosomal protein S7 0.0168341
DLC1 DLC1 Rho GTPase activating protein 0.0167421
SRSF11 serine/arginine-rich splicing factor 11 0.0167062
UBXN4 UBX domain protein 4 0.0166606
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0166065
SKIL SKI-like proto-oncogene 0.0164972
CYB5R3 cytochrome b5 reductase 3 0.0164419
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0163957
MYH9 myosin, heavy chain 9, non-muscle 0.0163257
TUFT1 tuftelin 1 0.0163064
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.0161326
JMJD1C jumonji domain containing 1C 0.0161128
PAWR PRKC, apoptosis, WT1, regulator 0.0159591

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.191295
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.166302
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122601
ERRFI1 ERBB receptor feedback inhibitor 1 -0.114718
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.103107
APOB apolipoprotein B -0.100989
TM4SF1 transmembrane 4 L six family member 1 -0.0945271
KDM3A lysine (K)-specific demethylase 3A -0.0863564
RPS24 ribosomal protein S24 -0.0839745
APOA2 apolipoprotein A-II -0.0823756
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0733833
ELL2 elongation factor, RNA polymerase II, 2 -0.0730048
H1-0 H1.0 linker histone -0.0691887
IGF2 insulin-like growth factor 2 -0.0688567
FNDC3B fibronectin type III domain containing 3B -0.0684347
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0648852
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0637101
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0597224
MT2A metallothionein 2A -0.0595741
EXT1 exostosin glycosyltransferase 1 -0.0588392
SVIL supervillin -0.0573588
ZMYND8 zinc finger, MYND-type containing 8 -0.0563462
ENO1 enolase 1, (alpha) -0.0560935
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0558092
RPLP1 ribosomal protein, large, P1 -0.0555424
FMNL2 formin-like 2 -0.0548525
WDR45B WD repeat domain 45B -0.0540651
RPL34 ribosomal protein L34 -0.0523831
GPC3 glypican 3 -0.0514697
FTL ferritin, light polypeptide -0.0509612
RPL12 ribosomal protein L12 -0.0507169
ATXN1 ataxin 1 -0.0501378
FRMD5 FERM domain containing 5 -0.0499868
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0484513
CCL20 chemokine (C-C motif) ligand 20 -0.0478824
STAU1 staufen double-stranded RNA binding protein 1 -0.047327
RPL35A ribosomal protein L35a -0.0465195
FN1 fibronectin 1 -0.0461025
AKAP12 A kinase (PRKA) anchor protein 12 -0.0459709
ASPH aspartate beta-hydroxylase -0.0437281
TMEM123 transmembrane protein 123 -0.0433837
RPS8 ribosomal protein S8 -0.042793
ZNF292 zinc finger protein 292 -0.041908
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0412295
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0411631
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0411079
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0403911
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0403233
IGFBP1 insulin-like growth factor binding protein 1 -0.0402982
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0401704
PGK1 phosphoglycerate kinase 1 -0.0401539
RPS6 ribosomal protein S6 -0.0399029
RPS27A ribosomal protein S27a -0.0393174
SBF2 SET binding factor 2 -0.0387282
PEG3 paternally expressed 3 -0.0378408
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0377089
RPS19 ribosomal protein S19 -0.0359927
TMSB10 thymosin beta 10 -0.0354858
RPLP0 ribosomal protein, large, P0 -0.0349763
RPS21 ribosomal protein S21 -0.0343238
RPS29 ribosomal protein S29 -0.0340749
NIPBL Nipped-B homolog (Drosophila) -0.0338634
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0335901
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0330597
RPL32 ribosomal protein L32 -0.0328255
NDRG1 N-myc downstream regulated 1 -0.0326464
PRELID2 PRELI domain containing 2 -0.0325091
RPS23 ribosomal protein S23 -0.0323669
NAMPT nicotinamide phosphoribosyltransferase -0.0312073
KRT8 keratin 8, type II -0.0308658
OSMR oncostatin M receptor -0.0305824
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0304737
RPL23 ribosomal protein L23 -0.0304361
KIAA1217 KIAA1217 -0.0302831
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0302759
DTNA dystrobrevin, alpha -0.0298173
A2M alpha-2-macroglobulin -0.0296506
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0292541
INSIG2 insulin induced gene 2 -0.0288442
PDIA3 protein disulfide isomerase family A, member 3 -0.0286187
AHNAK AHNAK nucleoprotein -0.0284728
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0284486
S100A10 S100 calcium binding protein A10 -0.0279986
RPL11 ribosomal protein L11 -0.0276405
SEC31A SEC31 homolog A (S. cerevisiae) -0.0273519
LRMDA leucine rich melanocyte differentiation associated -0.0272542
VIM vimentin -0.0271915
FUS FUS RNA binding protein -0.0271183
EPAS1 endothelial PAS domain protein 1 -0.027112
RPLP2 ribosomal protein, large, P2 -0.0269487
RUNX1 runt-related transcription factor 1 -0.0268725
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0266078
GRK3 G protein-coupled receptor kinase 3 -0.0264806
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0264634
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0260577
HOOK2 hook microtubule-tethering protein 2 -0.0260062
RPS11 ribosomal protein S11 -0.0257388
PDE8A phosphodiesterase 8A -0.0257106
MARCKS myristoylated alanine-rich protein kinase C substrate -0.02557
RPL5 ribosomal protein L5 -0.0255069