Neratinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF145 ring finger protein 145 0.0409612
TXNIP thioredoxin interacting protein 0.0379692
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0377313
EREG epiregulin 0.0353989
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0276622
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0275851
BIRC6 baculoviral IAP repeat containing 6 0.0247375
FNBP1L formin binding protein 1-like 0.0244353
FTH1 ferritin, heavy polypeptide 1 0.0227264
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0214197
WAC WW domain containing adaptor with coiled-coil 0.0213801
GOLGA4 golgin A4 0.0208956
CTBP2 C-terminal binding protein 2 0.0188544
WASF2 WAS protein family, member 2 0.0186902
MLEC malectin 0.0186836
PIGR polymeric immunoglobulin receptor 0.0184622
EHF ets homologous factor 0.0182993
NUP58 nucleoporin 58 0.0175974
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0174546
UBA6 ubiquitin-like modifier activating enzyme 6 0.0172383
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0171407
MED13L mediator complex subunit 13-like 0.0170578
KRT18 keratin 18, type I 0.0170121
SETD5 SET domain containing 5 0.0169477
PPARG peroxisome proliferator-activated receptor gamma 0.016886
YTHDC1 YTH domain containing 1 0.0168051
NCOR1 nuclear receptor corepressor 1 0.0166081
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0165587
PTBP3 polypyrimidine tract binding protein 3 0.0164521
FOXO1 forkhead box O1 0.0162148
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0161805
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0159321
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0158952
AFDN afadin, adherens junction formation factor 0.0158908
CUL3 cullin 3 0.015144
WDR43 WD repeat domain 43 0.015107
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0149907
SNX13 sorting nexin 13 0.0148564
GIGYF2 GRB10 interacting GYF protein 2 0.0148425
ADAM17 ADAM metallopeptidase domain 17 0.0147555
TMF1 TATA element modulatory factor 1 0.0141241
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.014121
ESRP1 epithelial splicing regulatory protein 1 0.0140134
CD46 CD46 molecule, complement regulatory protein 0.0139592
SLK STE20-like kinase 0.0139137
PTEN phosphatase and tensin homolog 0.0137982
SOS1 son of sevenless homolog 1 (Drosophila) 0.0137598
ESYT2 extended synaptotagmin-like protein 2 0.0136541
EXOC1 exocyst complex component 1 0.0136359
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0136058
COPA coatomer protein complex, subunit alpha 0.0135937
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.0135524
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0134339
PKN2 protein kinase N2 0.0134001
ARHGAP29 Rho GTPase activating protein 29 0.0133948
ETNK1 ethanolamine kinase 1 0.0133267
SENP6 SUMO1/sentrin specific peptidase 6 0.0132642
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0130558
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0129636
CHD9 chromodomain helicase DNA binding protein 9 0.0128942
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0128664
FAM13A family with sequence similarity 13, member A 0.0127654
LBR lamin B receptor 0.012751
ATP11B ATPase, class VI, type 11B 0.0127222
ITCH itchy E3 ubiquitin protein ligase 0.0125875
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.012556
COG5 component of oligomeric golgi complex 5 0.012305
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0122493
NCKAP1 NCK-associated protein 1 0.0122146
RAB6A RAB6A, member RAS oncogene family 0.0120706
UBE3A ubiquitin protein ligase E3A 0.0119439
CENPF centromere protein F, 350/400kDa 0.0118263
NKTR natural killer cell triggering receptor 0.0118207
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0117493
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0117345
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0117058
EPS8 epidermal growth factor receptor pathway substrate 8 0.0115076
SREBF2 sterol regulatory element binding transcription factor 2 0.0114011
ZMYM2 zinc finger, MYM-type 2 0.0113127
PCDHB16 protocadherin beta 16 0.0111809
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0111709
ARHGAP32 Rho GTPase activating protein 32 0.0111706
ZFC3H1 zinc finger, C3H1-type containing 0.011156
ITGA6 integrin, alpha 6 0.0111281
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0110952
NF1 neurofibromin 1 0.0109621
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0108479
ANKIB1 ankyrin repeat and IBR domain containing 1 0.010841
KDM2A lysine (K)-specific demethylase 2A 0.0108146
HELZ helicase with zinc finger 0.0107405
RARS1 arginyl-tRNA synthetase 1 0.0107195
PRRC1 proline-rich coiled-coil 1 0.0106996
MON2 MON2 homolog (S. cerevisiae) 0.0106566
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0105864
RFX7 regulatory factor X, 7 0.0105702
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0105426
U2SURP U2 snRNP-associated SURP domain containing 0.0105346
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0105282
FAM120A family with sequence similarity 120A 0.0104905
TNS4 tensin 4 0.0104357

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.16497
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153735
PTMA prothymosin, alpha -0.126003
TPT1 tumor protein, translationally-controlled 1 -0.110494
RPLP1 ribosomal protein, large, P1 -0.0985826
RPS6 ribosomal protein S6 -0.0980137
RPS19 ribosomal protein S19 -0.0847906
RPS8 ribosomal protein S8 -0.0790049
RPL35A ribosomal protein L35a -0.0768109
RPL34 ribosomal protein L34 -0.0700619
RPS12 ribosomal protein S12 -0.0699433
RPL23 ribosomal protein L23 -0.0686063
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0666443
RPLP2 ribosomal protein, large, P2 -0.0644906
RPL12 ribosomal protein L12 -0.0632933
RPL36 ribosomal protein L36 -0.0626562
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0552866
RPL37A ribosomal protein L37a -0.0544966
MT2A metallothionein 2A -0.0534724
FTL ferritin, light polypeptide -0.0527783
EZR ezrin -0.0521698
RPL9 ribosomal protein L9 -0.0521587
RPS24 ribosomal protein S24 -0.0515229
RPL26 ribosomal protein L26 -0.0501309
ONECUT3 one cut homeobox 3 -0.0492744
MYO1E myosin IE -0.0487277
RPL31 ribosomal protein L31 -0.0428642
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0425609
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0425591
RPL11 ribosomal protein L11 -0.0424232
RPL32 ribosomal protein L32 -0.0418247
RPL19 ribosomal protein L19 -0.0413412
RPL5 ribosomal protein L5 -0.0409374
RPS25 ribosomal protein S25 -0.0404448
RPS3 ribosomal protein S3 -0.0395583
RPS29 ribosomal protein S29 -0.0386432
VCL vinculin -0.0385341
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0381633
EIF1 eukaryotic translation initiation factor 1 -0.0381271
RPS13 ribosomal protein S13 -0.0378406
ACTG1 actin gamma 1 -0.0365644
GMDS GDP-mannose 4,6-dehydratase -0.0365321
RPS11 ribosomal protein S11 -0.0359777
RPS27 ribosomal protein S27 -0.0356352
EXT1 exostosin glycosyltransferase 1 -0.0347936
RPS23 ribosomal protein S23 -0.0345731
RPS21 ribosomal protein S21 -0.034552
RPL7A ribosomal protein L7a -0.0343227
RPL13A ribosomal protein L13a -0.0339152
ISG15 ISG15 ubiquitin-like modifier -0.0335249
RPS20 ribosomal protein S20 -0.0331395
S100P S100 calcium binding protein P -0.0330984
RPL28 ribosomal protein L28 -0.032937
RPS27A ribosomal protein S27a -0.0327672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0327072
PDE4D phosphodiesterase 4D, cAMP-specific -0.0321793
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0312757
AHNAK AHNAK nucleoprotein -0.0307535
RPL18 ribosomal protein L18 -0.0306713
S100A9 S100 calcium binding protein A9 -0.0300765
RPS17 ribosomal protein S17 -0.0297603
S100A10 S100 calcium binding protein A10 -0.0296728
RPL37 ribosomal protein L37 -0.0292
RPL35 ribosomal protein L35 -0.0285371
RPL7 ribosomal protein L7 -0.0283987
RPS10 ribosomal protein S10 -0.0283081
ASPH aspartate beta-hydroxylase -0.027662
NDRG1 N-myc downstream regulated 1 -0.0274665
KRT8 keratin 8, type II -0.0271931
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271346
AREG amphiregulin -0.0270175
RPS14 ribosomal protein S14 -0.0267023
RPL27 ribosomal protein L27 -0.0265725
KLF5 Kruppel-like factor 5 (intestinal) -0.0262291
ANTXR2 anthrax toxin receptor 2 -0.0260014
LOC112694756 uncharaterized LOC112694756 -0.0250013
RPS16 ribosomal protein S16 -0.0248191
CEMIP cell migration inducing protein, hyaluronan binding -0.0247847
KLF6 Kruppel-like factor 6 -0.0246901
RPLP0 ribosomal protein, large, P0 -0.0245845
PKM pyruvate kinase, muscle -0.0244863
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0241753
LOC102724023 ES1 protein homolog, mitochondrial -0.0241538
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0239501
RPL36A ribosomal protein L36a -0.023099
RPL8 ribosomal protein L8 -0.0230021
TPM4 tropomyosin 4 -0.0225265
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0223785
SMYD3 SET and MYND domain containing 3 -0.0223459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0222811
MUC13 mucin 13, cell surface associated -0.0222159
LMNA lamin A/C -0.0220217
RPL38 ribosomal protein L38 -0.0219424
RPL30 ribosomal protein L30 -0.0218947
RACK1 receptor for activated C kinase 1 -0.0217424
EGR1 early growth response 1 -0.0216431
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0214562
PTPRK protein tyrosine phosphatase, receptor type, K -0.0213858
RPS4X ribosomal protein S4, X-linked -0.0212483
CADPS Ca++-dependent secretion activator -0.0212306