Neratinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Neratinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0937324
CENPF centromere protein F, 350/400kDa 0.07241
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0694368
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0661045
KTN1 kinectin 1 (kinesin receptor) 0.0579712
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0547348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0503787
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0485076
DST dystonin 0.0469875
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0463574
KMT2E lysine (K)-specific methyltransferase 2E 0.0427457
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0414228
MKI67 marker of proliferation Ki-67 0.0408687
POTEF POTE ankyrin domain family, member F 0.0368265
TSC22D1 TSC22 domain family, member 1 0.0365525
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0362386
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0359258
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0340208
BIRC3 baculoviral IAP repeat containing 3 0.0329543
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.032749
ENO1 enolase 1, (alpha) 0.0326734
LDHA lactate dehydrogenase A 0.0326206
APLP2 amyloid beta (A4) precursor-like protein 2 0.0306518
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0301568
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0300586
CAPRIN2 caprin family member 2 0.0296635
WWTR1 WW domain containing transcription regulator 1 0.0294989
CANX calnexin 0.0294119
XPO1 exportin 1 0.0287821
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0286306
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0285789
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0284347
SMC4 structural maintenance of chromosomes 4 0.0280886
PGK1 phosphoglycerate kinase 1 0.0275966
SLK STE20-like kinase 0.0273323
PLK2 polo-like kinase 2 0.0271608
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0271228
TRIP12 thyroid hormone receptor interactor 12 0.0267596
PCBP2 poly(rC) binding protein 2 0.0267445
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0261396
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0255545
MYH9 myosin, heavy chain 9, non-muscle 0.0252035
BCAR3 breast cancer anti-estrogen resistance 3 0.0250846
FXR1 fragile X mental retardation, autosomal homolog 1 0.0250765
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249451
F2R coagulation factor II (thrombin) receptor 0.0248054
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0245202
ANGPTL4 angiopoietin-like 4 0.0239048
SRRM2 serine/arginine repetitive matrix 2 0.0238756
ZNF292 zinc finger protein 292 0.023846
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0236429
EHBP1 EH domain binding protein 1 0.0234321
MYO10 myosin X 0.0230635
NUP58 nucleoporin 58 0.0228301
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0227871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0226048
VMP1 vacuole membrane protein 1 0.021927
PIAS2 protein inhibitor of activated STAT, 2 0.0216544
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0215402
TPR translocated promoter region, nuclear basket protein 0.0215256
SLC38A2 solute carrier family 38, member 2 0.0214898
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0214138
KMT2C lysine (K)-specific methyltransferase 2C 0.0213128
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0212195
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0210902
TBC1D5 TBC1 domain family, member 5 0.0208896
EEF2 eukaryotic translation elongation factor 2 0.0208881
TPX2 TPX2, microtubule-associated 0.0207721
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0206257
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0206241
BCLAF1 BCL2-associated transcription factor 1 0.0203437
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0202937
SMAD3 SMAD family member 3 0.0198052
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0197531
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0197441
KIF5B kinesin family member 5B 0.0193812
SFPQ splicing factor proline/glutamine-rich 0.0192968
TOP1 topoisomerase (DNA) I 0.0188547
CDK19 cyclin-dependent kinase 19 0.0187058
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0186695
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0185964
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.018546
CBX3 chromobox homolog 3 0.0184463
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0183096
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0180501
TAPBP TAP binding protein (tapasin) 0.0179636
VCL vinculin 0.0177819
ADAM10 ADAM metallopeptidase domain 10 0.0175312
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0173953
WAC WW domain containing adaptor with coiled-coil 0.0171287
SET SET nuclear proto-oncogene 0.0169749
MSN moesin 0.0169561
MBNL1 muscleblind-like splicing regulator 1 0.0167462
CSDE1 cold shock domain containing E1, RNA-binding 0.0167239
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0166381
ERBIN erbb2 interacting protein 0.016594
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0165884
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0165183
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0165066
RAI1 retinoic acid induced 1 0.0165044

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.260552
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190897
TMSB10 thymosin beta 10 -0.129064
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12111
TPT1 tumor protein, translationally-controlled 1 -0.0661288
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0596512
RPL35A ribosomal protein L35a -0.058685
TP63 tumor protein p63 -0.0578759
RPL12 ribosomal protein L12 -0.0500616
FTL ferritin, light polypeptide -0.0492909
KLF6 Kruppel-like factor 6 -0.0481472
RPS19 ribosomal protein S19 -0.0441306
RPS8 ribosomal protein S8 -0.0440996
HLA-B major histocompatibility complex, class I, B -0.0407383
RPLP1 ribosomal protein, large, P1 -0.0404037
GARS1 glycyl-tRNA synthetase 1 -0.0395302
RPS6 ribosomal protein S6 -0.0361983
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0360252
RPL36 ribosomal protein L36 -0.0355779
EZR ezrin -0.0345602
RAB7A RAB7A, member RAS oncogene family -0.0341523
TM4SF1 transmembrane 4 L six family member 1 -0.0314591
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.03145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.031043
IARS1 isoleucyl-tRNA synthetase 1 -0.030916
DLG1 discs, large homolog 1 (Drosophila) -0.0301228
S100A10 S100 calcium binding protein A10 -0.0299105
RPL38 ribosomal protein L38 -0.0293109
RPL26 ribosomal protein L26 -0.0282838
ACTG1 actin gamma 1 -0.0278593
RPS24 ribosomal protein S24 -0.0275855
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0271294
RPLP2 ribosomal protein, large, P2 -0.026333
RPL23 ribosomal protein L23 -0.0261271
RPL34 ribosomal protein L34 -0.0260306
FUS FUS RNA binding protein -0.0257154
EIF1 eukaryotic translation initiation factor 1 -0.0253209
JMJD1C jumonji domain containing 1C -0.0249152
ANXA1 annexin A1 -0.0244162
RPL28 ribosomal protein L28 -0.0243103
RPL37A ribosomal protein L37a -0.0242288
RPS23 ribosomal protein S23 -0.0241083
RPL8 ribosomal protein L8 -0.0213837
RPL35 ribosomal protein L35 -0.0211841
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0210339
SLC38A1 solute carrier family 38, member 1 -0.0209864
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.020839
RPL31 ribosomal protein L31 -0.0207922
RPL19 ribosomal protein L19 -0.0204564
RTN4 reticulon 4 -0.0202915
ANKRD11 ankyrin repeat domain 11 -0.0202661
RPL11 ribosomal protein L11 -0.0202275
RPS12 ribosomal protein S12 -0.0201088
GNAS GNAS complex locus -0.0195592
RPL36A ribosomal protein L36a -0.0194807
MT2A metallothionein 2A -0.0194139
ZFAND3 zinc finger, AN1-type domain 3 -0.019119
RPS29 ribosomal protein S29 -0.0189397
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0185873
RPS27A ribosomal protein S27a -0.0184949
RPL37 ribosomal protein L37 -0.0179263
RPL27 ribosomal protein L27 -0.0179153
RPL32 ribosomal protein L32 -0.0178799
PTMA prothymosin, alpha -0.0177407
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0175324
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0172242
WSB1 WD repeat and SOCS box containing 1 -0.0171837
PRDX1 peroxiredoxin 1 -0.0168959
FTH1 ferritin, heavy polypeptide 1 -0.0167471
RPS28 ribosomal protein S28 -0.0166134
RPL9 ribosomal protein L9 -0.0164838
RPS21 ribosomal protein S21 -0.0157584
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0155879
NDRG1 N-myc downstream regulated 1 -0.0155158
RPS10 ribosomal protein S10 -0.0155093
FLNB filamin B, beta -0.0153316
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0152918
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0152363
TXNRD1 thioredoxin reductase 1 -0.0151615
FBXO11 F-box protein 11 -0.0148308
H1-0 H1.0 linker histone -0.0145357
RPS20 ribosomal protein S20 -0.0143548
S100A6 S100 calcium binding protein A6 -0.0142042
RPL5 ribosomal protein L5 -0.0141581
RACK1 receptor for activated C kinase 1 -0.0138181
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0136555
WARS1 tryptophanyl-tRNA synthetase 1 -0.0136479
RPS14 ribosomal protein S14 -0.0134541
TSC22D2 TSC22 domain family, member 2 -0.013393
ANK2 ankyrin 2, neuronal -0.0133449
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0132765
ANXA2 annexin A2 -0.0132441
RPS4X ribosomal protein S4, X-linked -0.0131643
S100A9 S100 calcium binding protein A9 -0.0131332
HDAC9 histone deacetylase 9 -0.0130869
RPS27 ribosomal protein S27 -0.0130827
SPIRE1 spire-type actin nucleation factor 1 -0.0130587
NPR2 natriuretic peptide receptor 2 -0.0130307
ATF4 activating transcription factor 4 -0.0129412
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0128876